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IID00798
 UniprotP35251
ProteinReplication factor C subunit 1
GeneRFC1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1148
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 375-496 Monomer :
 Evidence NMR 2k7f A Reference
       Region 2k7f A 375-480 order
       Region 2k7f A 375-381 high_rmsd
 Evidence NMR 2ebu A Reference
       Region 2ebu A 392-496 order
       Region 2ebu A 392-393 high_rmsd
       Region 2ebu A 488-496 high_rmsd
 Evidence NMR 2k6g A Reference
       Region 2k6g A 375-480 order
       Region 2k6g A 375-396 high_rmsd
Seqphosphorylation
    1104-1104 Phosphoserine
    1106-1106 Phosphoserine
    537-537 Phosphoserine
    161-161 Phosphothreonine
    312-312 Phosphoserine
    283-283 Phosphoserine
    281-281 Phosphoserine
    253-253 Phosphoserine
    190-190 Phosphoserine
    173-173 Phosphoserine
    164-164 Phosphoserine
    163-163 Phosphothreonine
    368-368 Phosphoserine
    73-73 Phosphoserine
    108-108 Phosphoserine
    156-156 Phosphoserine
    110-110 Phosphothreonine
    71-71 Phosphoserine
    69-69 Phosphoserine
    67-67 Phosphotyrosine
 
Prediction
NeProc
Disorder 1-402,438-443,486-581,628-638,707-712,950-971,1067-1148
Order 403-437,444-485,582-627,639-706,713-949,972-1066
ProS 1-9,63-69,105-109,115-118,164-169,201-211,224-227,260-265,375-385,396-402,486-498,514-523,631-638,950-971,1067-1078,1115-1120
AlphaFold
Disorder 1-200,215-228,230-376,381-381,384-384,388-388,486-493,496-580,621-640,704-712,806-806,827-830,833-833,836-847,860-861,863-863,1074-1074,1076-1148
Order 201-214,229-229,377-380,382-383,385-387,389-485,494-495,581-620,641-703,713-805,807-826,831-832,834-835,848-859,862-862,864-1073,1075-1075
Pfam Hmmer
PF00533 402-479 8.9e-22
PF00004 646-824 4.6e-11
PF08519 915-1068 2.2e-97
SEG 142-153 ,286-303 ,346-366 ,514-534 ,1101-1112 ,1121-1140
Function
Function in SwissProt
Interacts with C-terminus of PCNA. 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair.
Biological Process
See also
Diagram with PDB data
XPA/ERCC1Solution structure of a ERCC1-XPA heterodimer
MSH2/MSH6/DNAhuman MutSalpha (MSH2/MSH6) bound to ADP and a G T mispair
MSH2/MSH3/DNAHuman MutSbeta complexed with an IDL of 4 bases (Loop4) and ADP