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IID00803
 UniprotP42575
ProteinCaspase-2
GeneCASP2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
452
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 135-168 Hetero dimer : IID00816Complex
 Evidence X-RAY 6s9k B Reference
       Region 6s9k B 135-136 disorder
       Region 6s9k B 137-158 order
       Region 6s9k B 159-168 disorder
Seq 135-168 Hetero trimer : IID00816Complex
 Evidence X-RAY 6sad C Reference
       Region 6sad C 135-148 order
       Region 6sad C 149-161 disorder
       Region 6sad C 162-166 order
       Region 6sad C 167-168 disorder
Seq 136-143 Hetero hexadecamer : IID00816Complex
 Evidence X-RAY 6gkf P Reference
       Region 6gkf P 136-143 order
 Evidence X-RAY 6gkf O Reference
       Region 6gkf O 136-143 order
 Evidence X-RAY 6gkf N Reference
       Region 6gkf N 136-136 disorder
       Region 6gkf N 137-142 order
       Region 6gkf N 143-143 disorder
 Evidence X-RAY 6gkf M Reference
       Region 6gkf M 136-143 order
 Evidence X-RAY 6gkf L Reference
       Region 6gkf L 136-136 disorder
       Region 6gkf L 137-142 order
       Region 6gkf L 143-143 disorder
 Evidence X-RAY 6gkf K Reference
       Region 6gkf K 136-143 order
 Evidence X-RAY 6gkf J Reference
       Region 6gkf J 136-142 order
       Region 6gkf J 143-143 disorder
 Evidence X-RAY 6gkf I Reference
       Region 6gkf I 136-143 order
Seq 136-143 Hetero dimer : IID00301Complex
 Evidence X-RAY 6y8b P Reference
       Region 6y8b P 136-143 order
Seq 161-168 Hetero dimer : IID00301Complex
 Evidence X-RAY 6y8d B Reference
       Region 6y8d B 161-161 disorder
       Region 6y8d B 162-165 order
       Region 6y8d B 166-168 disorder
Seq 161-168 Hetero tetradecamer : IID00816Complex
 Evidence X-RAY 6gkg N Reference
       Region 6gkg N 161-161 disorder
       Region 6gkg N 162-166 order
       Region 6gkg N 167-168 disorder
 Evidence X-RAY 6gkg M Reference
       Region 6gkg M 161-167 order
       Region 6gkg M 168-168 disorder
 Evidence X-RAY 6gkg L Reference
       Region 6gkg L 161-163 disorder
       Region 6gkg L 164-166 order
       Region 6gkg L 167-168 disorder
 Evidence X-RAY 6gkg K Reference
       Region 6gkg K 161-163 disorder
       Region 6gkg K 164-166 order
       Region 6gkg K 167-168 disorder
 Evidence X-RAY 6gkg J Reference
       Region 6gkg J 161-163 disorder
       Region 6gkg J 164-166 order
       Region 6gkg J 167-168 disorder
 Evidence X-RAY 6gkg I Reference
       Region 6gkg I 161-166 order
       Region 6gkg I 167-168 disorder
Seq 167-333,348-452 Hetero hexamer :
 Evidence X-RAY 2p2c L Reference
       Region 2p2c L 348-357 disorder
       Region 2p2c L 358-449 order
       Region 2p2c L 450-452 disorder
 Evidence X-RAY 2p2c J Reference
       Region 2p2c J 348-355 disorder
       Region 2p2c J 356-449 order
       Region 2p2c J 450-452 disorder
 Evidence X-RAY 2p2c K Reference
       Region 2p2c K 167-173 disorder
       Region 2p2c K 174-331 order
       Region 2p2c K 332-333 disorder
 Evidence X-RAY 2p2c I Reference
       Region 2p2c I 167-175 disorder
       Region 2p2c I 176-332 order
       Region 2p2c I 333-333 disorder
Seq 167-333,348-452 Hetero tetramer :
 Evidence X-RAY 3r7b A Reference
       Region 3r7b A 175-212 order
       Region 3r7b A 213-215 disorder
       Region 3r7b A 216-332 order
       Region 3r7b A 333-333 disorder
 Evidence X-RAY 3r7b C Reference
       Region 3r7b C 175-332 order
       Region 3r7b C 333-333 disorder
 Evidence X-RAY 3rjm A Reference
       Region 3rjm A 167-173 disorder
       Region 3rjm A 174-332 order
       Region 3rjm A 333-333 disorder
 Evidence X-RAY 3rjm C Reference
       Region 3rjm C 167-173 disorder
       Region 3rjm C 174-333 order
 Evidence X-RAY 3r7b B Reference
       Region 3r7b B 349-354 disorder
       Region 3r7b B 355-423 order
       Region 3r7b B 424-425 disorder
       Region 3r7b B 426-451 order
       Region 3r7b B 452-452 disorder
 Evidence X-RAY 3r7b D Reference
       Region 3r7b D 349-355 disorder
       Region 3r7b D 356-451 order
       Region 3r7b D 452-452 disorder
 Evidence X-RAY 3rjm B Reference
       Region 3rjm B 348-353 disorder
       Region 3rjm B 354-450 order
       Region 3rjm B 451-452 disorder
 Evidence X-RAY 3rjm D Reference
       Region 3rjm D 348-354 disorder
       Region 3rjm D 355-451 order
       Region 3rjm D 452-452 disorder
Seq 167-333,348-452 Hetero hexamer : P36114
 Evidence X-RAY 1pyo D Reference
       Region 1pyo D 348-353 disorder
       Region 1pyo D 354-452 order
 Evidence X-RAY 1pyo B Reference
       Region 1pyo B 348-353 disorder
       Region 1pyo B 354-451 order
       Region 1pyo B 452-452 disorder
 Evidence X-RAY 1pyo C Reference
       Region 1pyo C 167-172 disorder
       Region 1pyo C 173-333 order
 Evidence X-RAY 1pyo A Reference
       Region 1pyo A 167-173 disorder
       Region 1pyo A 174-332 order
       Region 1pyo A 333-333 disorder
Seq 167-333,348-452 Hetero hexamer :
 Evidence X-RAY 2p2c D Reference
       Region 2p2c D 348-354 disorder
       Region 2p2c D 355-452 order
 Evidence X-RAY 2p2c B Reference
       Region 2p2c B 348-355 disorder
       Region 2p2c B 356-451 order
       Region 2p2c B 452-452 disorder
 Evidence X-RAY 2p2c C Reference
       Region 2p2c C 167-172 disorder
       Region 2p2c C 173-333 order
 Evidence X-RAY 2p2c A Reference
       Region 2p2c A 167-171 disorder
       Region 2p2c A 172-333 order
Seq 167-333,348-452 Hetero hexamer :
 Evidence X-RAY 2p2c H Reference
       Region 2p2c H 348-353 disorder
       Region 2p2c H 354-451 order
       Region 2p2c H 452-452 disorder
 Evidence X-RAY 2p2c F Reference
       Region 2p2c F 348-355 disorder
       Region 2p2c F 356-451 order
       Region 2p2c F 452-452 disorder
 Evidence X-RAY 2p2c G Reference
       Region 2p2c G 167-172 disorder
       Region 2p2c G 173-332 order
       Region 2p2c G 333-333 disorder
 Evidence X-RAY 2p2c E Reference
       Region 2p2c E 167-172 disorder
       Region 2p2c E 173-332 order
       Region 2p2c E 333-333 disorder
Seq 175-333,349-452 Hetero dimer :
 Evidence X-RAY 3r5j A Reference
       Region 3r5j A 175-210 order
       Region 3r5j A 211-215 disorder
       Region 3r5j A 216-332 order
       Region 3r5j A 333-333 disorder
 Evidence X-RAY 3r5j C Reference
       Region 3r5j C 175-332 order
       Region 3r5j C 333-333 disorder
 Evidence X-RAY 3r6g A Reference
       Region 3r6g A 175-212 order
       Region 3r6g A 213-214 disorder
       Region 3r6g A 215-332 order
       Region 3r6g A 333-333 disorder
 Evidence X-RAY 3r6g C Reference
       Region 3r6g C 175-333 order
 Evidence X-RAY 3r6l A Reference
       Region 3r6l A 175-211 order
       Region 3r6l A 212-215 disorder
       Region 3r6l A 216-332 order
       Region 3r6l A 333-333 disorder
 Evidence X-RAY 3r6l C Reference
       Region 3r6l C 175-333 order
 Evidence X-RAY 3r7n A Reference
       Region 3r7n A 175-210 order
       Region 3r7n A 211-215 disorder
       Region 3r7n A 216-332 order
       Region 3r7n A 333-333 disorder
 Evidence X-RAY 3r7n C Reference
       Region 3r7n C 175-333 order
 Evidence X-RAY 3r7s A Reference
       Region 3r7s A 175-332 order
       Region 3r7s A 333-333 disorder
 Evidence X-RAY 3r7s C Reference
       Region 3r7s C 175-332 order
       Region 3r7s C 333-333 disorder
 Evidence X-RAY 3r5j B Reference
       Region 3r5j B 349-354 disorder
       Region 3r5j B 355-451 order
       Region 3r5j B 452-452 disorder
 Evidence X-RAY 3r5j D Reference
       Region 3r5j D 349-354 disorder
       Region 3r5j D 355-451 order
       Region 3r5j D 452-452 disorder
 Evidence X-RAY 3r6g B Reference
       Region 3r6g B 349-354 disorder
       Region 3r6g B 355-451 order
       Region 3r6g B 452-452 disorder
 Evidence X-RAY 3r6g D Reference
       Region 3r6g D 349-354 disorder
       Region 3r6g D 355-451 order
       Region 3r6g D 452-452 disorder
 Evidence X-RAY 3r6l B Reference
       Region 3r6l B 349-354 disorder
       Region 3r6l B 355-451 order
       Region 3r6l B 452-452 disorder
 Evidence X-RAY 3r6l D Reference
       Region 3r6l D 349-353 disorder
       Region 3r6l D 354-451 order
       Region 3r6l D 452-452 disorder
 Evidence X-RAY 3r7n B Reference
       Region 3r7n B 349-354 disorder
       Region 3r7n B 355-452 order
 Evidence X-RAY 3r7n D Reference
       Region 3r7n D 349-354 disorder
       Region 3r7n D 355-451 order
       Region 3r7n D 452-452 disorder
 Evidence X-RAY 3r7s B Reference
       Region 3r7s B 349-353 disorder
       Region 3r7s B 354-451 order
       Region 3r7s B 452-452 disorder
 Evidence X-RAY 3r7s D Reference
       Region 3r7s D 349-356 disorder
       Region 3r7s D 357-451 order
       Region 3r7s D 452-452 disorder
SeqProS predicted 135-158 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00301Complex
       Region 6y8b P 136-143 order
SeqProS predicted 135-158 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero hexadecamer : IID00816Complex
       Region 6gkf I 136-143 order
       Region 6gkf J 136-142 order
       Region 6gkf K 136-143 order
       Region 6gkf L 137-142 order
       Region 6gkf M 136-143 order
       Region 6gkf N 137-142 order
       Region 6gkf O 136-143 order
       Region 6gkf P 136-143 order
SeqProS predicted 135-158 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00816Complex
       Region 6s9k B 137-158 order
SeqProS predicted 135-158,161-167 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero trimer : IID00816Complex
       Region 6sad C 135-148 order
       Region 6sad C 162-166 order
SeqProS predicted 161-167 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero tetradecamer : IID00816Complex
       Region 6gkg I 161-166 order
       Region 6gkg M 161-167 order
       Region 6gkg N 162-166 order
       Region 6gkg J 164-166 order
       Region 6gkg K 164-166 order
       Region 6gkg L 164-166 order
SeqProS predicted 161-167 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00301Complex
       Region 6y8d B 162-165 order
Seqphosphorylation
    157-157 Phosphoserine
    340-340 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-5,129-181,336-353
Order 6-77,82-122,182-335,354-452
ProS 1-5,134-147,164-181
AlphaFold
Disorder 1-31,126-172,213-214,333-355,452-452
Order 32-125,173-212,215-332,356-451
Pfam Hmmer
PF00619 37-121 8.8e-26
PF00656 200-445 2.8e-74
SEG 51-62
Function
Function in SwissProt
Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321).