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IID00804
 UniprotP49459
ProteinUbiquitin-conjugating enzyme E2 A
GeneUBE2A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
152
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-152 Monomer :
 Evidence X-RAY 6cyo A Reference
       Region 6cyo A 1-151 order
       Region 6cyo A 152-152 disorder
 Evidence X-RAY 6cyr A Reference
       Region 6cyr A 1-152 order
Seqphosphorylation
    120-120 Phosphoserine; by CDK9
 
Prediction
NeProc
Disorder 1-4
Order 5-152
AlphaFold
Disorder 1-1,152-152
Order 2-151
Pfam Hmmer
PF00179 8-145 4.2e-82
Function
Function in SwissProt
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.