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IID00805
 UniprotP49675
ProteinSteroidogenic acute regulatory protein, mitochondrial
GeneSTAR
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
285
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 54-62
 Evidence X-RAY 5oma D Reference
       Region 5oma D 54-62 disorder
Seq 54-62 Hetero tetramer : IID00301Complex
 Evidence X-RAY 5oma B Reference
       Region 5oma B 54-55 order
       Region 5oma B 56-62 disorder
Seq 54-62 Hetero tetramer : IID00301Complex
 Evidence X-RAY 6t5h B Reference
       Region 6t5h B 54-59 order
       Region 6t5h B 60-62 disorder
 Evidence X-RAY 6t5h A Reference
       Region 6t5h A 54-54 disorder
       Region 6t5h A 55-59 order
       Region 6t5h A 60-62 disorder
Seqdisorder 54-62
 Evidence X-RAY 5oma C Reference
       Region 5oma C 54-62 disorder
Seqdisorder 54-62
 Evidence X-RAY 5oma A Reference
       Region 5oma A 54-62 disorder
Seq 66-284 Monomer :
 Evidence X-RAY 3p0l A Reference
       Region 3p0l A 66-173 order
       Region 3p0l A 174-176 disorder
       Region 3p0l A 177-276 order
       Region 3p0l A 277-284 disorder
 Evidence X-RAY 3p0l B Reference
       Region 3p0l B 66-172 order
       Region 3p0l B 173-177 disorder
       Region 3p0l B 178-276 order
       Region 3p0l B 277-284 disorder
 Evidence X-RAY 3p0l C Reference
       Region 3p0l C 66-92 order
       Region 3p0l C 93-93 disorder
       Region 3p0l C 94-172 order
       Region 3p0l C 173-177 disorder
       Region 3p0l C 178-213 order
       Region 3p0l C 214-215 disorder
       Region 3p0l C 216-276 order
       Region 3p0l C 277-284 disorder
 Evidence X-RAY 3p0l D Reference
       Region 3p0l D 66-101 order
       Region 3p0l D 102-106 disorder
       Region 3p0l D 107-171 order
       Region 3p0l D 172-177 disorder
       Region 3p0l D 178-179 order
       Region 3p0l D 180-181 disorder
       Region 3p0l D 182-248 order
       Region 3p0l D 249-261 disorder
       Region 3p0l D 262-274 order
       Region 3p0l D 275-284 disorder
Seq 192-200 Hetero octamer : IID00301Complex
 Evidence X-RAY 6t5f H Reference
       Region 6t5f H 192-197 order
       Region 6t5f H 198-200 disorder
 Evidence X-RAY 6t5f G Reference
       Region 6t5f G 192-197 order
       Region 6t5f G 198-200 disorder
 Evidence X-RAY 6t5f F Reference
       Region 6t5f F 192-200 order
 Evidence X-RAY 6t5f E Reference
       Region 6t5f E 192-200 order
SeqProS predicted 54-59 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero tetramer : IID00301Complex
       Region 6t5h A 55-59 order
       Region 6t5h B 54-59 order
SeqProS predicted 54-59 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero tetramer : IID00301Complex
       Region 5oma B 54-55 order
Seqphosphorylation
    57-57 Phosphoserine; by PKA
    195-195 Phosphoserine; by PKA
 
Prediction
NeProc
Disorder 37-67,280-285
Order 1-36,68-279
ProS 37-40,47-54,62-67,280-285
AlphaFold
Disorder 1-66,280-285
Order 67-279
Pfam Hmmer
PF01852 76-281 1.5e-77
SEG 53-63
Function
Function in SwissProt
Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.