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IID00809
 UniprotP53990
ProteinIST1 homolog
GeneIST1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
364
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-189 Monomer :
 Evidence X-RAY 3frs A Reference
       Region 3frs A 5-90 order
       Region 3frs A 91-91 disorder
       Region 3frs A 92-180 order
       Region 3frs A 181-189 disorder
 Evidence X-RAY 3frr A Reference
       Region 3frr A 1-1 disorder
       Region 3frr A 2-187 order
       Region 3frr A 188-189 disorder
Seq 320-364 Hetero tetramer : Q9Y6W3
 Evidence X-RAY 8uc6 G Reference
       Region 8uc6 G 320-321 disorder
       Region 8uc6 G 322-330 order
       Region 8uc6 G 331-346 disorder
       Region 8uc6 G 347-362 order
       Region 8uc6 G 363-364 disorder
 Evidence X-RAY 8uc6 E Reference
       Region 8uc6 E 320-321 disorder
       Region 8uc6 E 322-330 order
       Region 8uc6 E 331-346 disorder
       Region 8uc6 E 347-362 order
       Region 8uc6 E 363-364 disorder
Seq 341-364 Hetero dimer : IID00760Complex
 Evidence X-RAY 4u7y B Reference
       Region 4u7y B 341-348 disorder
       Region 4u7y B 349-361 order
       Region 4u7y B 362-364 disorder
Seq 341-364 Hetero dimer : IID00881Complex
 Evidence X-RAY 4u7e A Reference
       Region 4u7e A 341-348 disorder
       Region 4u7e A 349-362 order
       Region 4u7e A 363-364 disorder
Seq 341-364 Hetero dimer : Q8N0X7
 Evidence X-RAY 4u7i B Reference
       Region 4u7i B 341-346 disorder
       Region 4u7i B 347-362 order
       Region 4u7i B 363-364 disorder
Seq 342-364 Hetero dimer : Q6PHR2
 Evidence X-RAY 4wzx E Reference
       Region 4wzx E 342-346 disorder
       Region 4wzx E 347-362 order
       Region 4wzx E 363-364 disorder
Seq 342-364 Hetero dimer : Q9UBP0
 Evidence X-RAY 7s7j B Reference
       Region 7s7j B 342-346 disorder
       Region 7s7j B 347-364 order
SeqProS predicted 322-330,347-364 Same region of the homolog (Q9Y3E7, CHMP3) is disordered in the free state (PubMed=21827950). Hetero tetramer : Q9Y6W3
       Region 8uc6 E 322-330 order
       Region 8uc6 G 322-330 order
       Region 8uc6 E 347-362 order
       Region 8uc6 G 347-362 order
SeqProS possible 347-364 Same region of the homolog (Q9Y3E7, CHMP3) is disordered in the free state (PubMed=21827950). Hetero dimer : IID00760Complex
       Region 4u7y B 349-361 order
SeqProS possible 347-364 Same region of the homolog (Q9Y3E7, CHMP3) is disordered in the free state (PubMed=21827950). Hetero dimer : IID00881Complex
       Region 4u7e A 349-362 order
SeqProS possible 347-364 Same region of the homolog (Q9Y3E7, CHMP3) is disordered in the free state (PubMed=21827950). Hetero dimer : Q6PHR2
       Region 4wzx E 347-362 order
SeqProS possible 347-364 Same region of the homolog (Q9Y3E7, CHMP3) is disordered in the free state (PubMed=21827950). Hetero dimer : Q8N0X7
       Region 4u7i B 347-362 order
SeqProS possible 347-364 Same region of the homolog (Q9Y3E7, CHMP3) is disordered in the free state (PubMed=21827950). Hetero dimer : Q9UBP0
       Region 7s7j B 347-364 order
Seqphosphorylation
    43-43 Phosphotyrosine
    4-4 Phosphoserine
 
Prediction
NeProc
Disorder 1-6,182-364
Order 7-181
ProS 1-6,195-201,264-278,299-302,317-333,346-364
AlphaFold
Disorder 1-3,187-347,364-364
Order 4-186,348-363
Pfam Hmmer
PF03398 17-139 5.1e-75
SEG 10-32 ,207-216 ,229-237 ,335-345
Function
Function in SwissProt
ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation (PubMed:19129479, PubMed:26040712, PubMed:28242692). Is required for efficient abscission during cytokinesis (PubMed:19129479). Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129480, PubMed:19129479). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (PubMed:28242692). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888).