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IID00810
 UniprotP54253
ProteinAtaxin-1
GeneATXN1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
815
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 562-688 Hetero dimer : IID00865Complex
 Evidence X-RAY 4j2j A Reference
       Region 4j2j A 562-567 disorder
       Region 4j2j A 568-688 order
 Evidence X-RAY 4j2j B Reference
       Region 4j2j B 562-567 disorder
       Region 4j2j B 568-622 order
       Region 4j2j B 623-625 disorder
       Region 4j2j B 626-688 order
 Evidence X-RAY 4j2j C Reference
       Region 4j2j C 562-569 disorder
       Region 4j2j C 570-606 order
       Region 4j2j C 607-607 disorder
       Region 4j2j C 608-685 order
       Region 4j2j C 686-688 disorder
Seq 562-688 Hetero dimer : IID00865Complex
 Evidence X-RAY 4j2l A Reference
       Region 4j2l A 562-567 disorder
       Region 4j2l A 568-688 order
 Evidence X-RAY 4j2l B Reference
       Region 4j2l B 562-565 disorder
       Region 4j2l B 566-688 order
Seq 562-693 Homo tetramer :
 Evidence X-RAY 1oa8 D Reference
       Region 1oa8 D 562-693 order
 Evidence X-RAY 1oa8 C Reference
       Region 1oa8 C 562-689 order
       Region 1oa8 C 690-693 disorder
 Evidence X-RAY 1oa8 B Reference
       Region 1oa8 B 562-688 order
       Region 1oa8 B 689-693 disorder
 Evidence X-RAY 1oa8 A Reference
       Region 1oa8 A 562-688 order
       Region 1oa8 A 689-693 disorder
Seq 566-688 Hetero dimer : IID00865Complex
 Evidence NMR 2m41 B Reference
       Region 2m41 B 566-688 order
       Region 2m41 B 566-568 high_rmsd
Seq 566-688 Homo dimer :
 Evidence X-RAY 4apt A Reference
       Region 4apt A 566-688 order
 Evidence X-RAY 4apt B Reference
       Region 4apt B 566-688 order
 Evidence X-RAY 4apt C Reference
       Region 4apt C 566-688 order
 Evidence X-RAY 4apt D Reference
       Region 4apt D 566-687 order
       Region 4apt D 688-688 disorder
 Evidence X-RAY 4aqp A Reference
       Region 4aqp A 566-688 order
 Evidence X-RAY 4aqp B Reference
       Region 4aqp B 566-688 order
 Evidence X-RAY 4aqp C Reference
       Region 4aqp C 566-688 order
 Evidence X-RAY 4aqp D Reference
       Region 4aqp D 566-688 order
Seqdisorder 689-815
 Evidence SAXS Reference
       Region 689-815 disorder
Seq 771-780 Hetero dimer : IID00301Complex
 Evidence X-RAY 6qiu P Reference
       Region 6qiu P 771-780 order
SeqProS verified 562-565 Homo tetramer :
       Region 1oa8 A 562-688 order
       Region 1oa8 B 562-688 order
       Region 1oa8 C 562-689 order
       Region 1oa8 D 562-693 order
       Region 4j2l B 562-565 disorder
SeqProS verified 771-780 Hetero dimer : IID00301Complex
       Region 6qiu P 771-780 order
       Region 689-815 disorder
Seqphosphorylation
    82-82 Phosphoserine
    88-88 Phosphoserine
    238-238 Phosphoserine
    253-253 Phosphoserine
    775-775 Phosphoserine
 
Prediction
NeProc
Disorder 1-191,225-573,689-803,810-815
Order 192-224,574-688,804-809
ProS 1-22,43-47,123-129,324-327,483-486,570-573,770-803,810-815
AlphaFold
Disorder 1-195,223-569,690-797,809-815
Order 196-222,570-689,798-808
Pfam Hmmer
PF08517 574-688 4.9e-77
SEG 47-64 ,88-99 ,154-169 ,197-226 ,365-376 ,554-572
Function
Function in SwissProt
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism (PubMed:21475249). In concert with CIC and ATXN1L, involved in brain development (By similarity).