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IID00813
 UniprotP60903
ProteinProtein S100-A10
GeneS100A10
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
97
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-93 Hetero trimer : IID00700Complex,IID00724Complex
 Evidence X-RAY 4hrh A Reference
       Region 4hrh A 1-1 disorder
       Region 4hrh A 2-92 order
       Region 4hrh A 93-93 disorder
Seq 1-93 Hetero pentamer : IID00700Complex,IID00824Complex
 Evidence X-RAY 4drw D Reference
       Region 4drw D 1-1 disorder
       Region 4drw D 2-92 order
       Region 4drw D 93-93 disorder
 Evidence X-RAY 4drw C Reference
       Region 4drw C 1-1 disorder
       Region 4drw C 2-92 order
       Region 4drw C 93-93 disorder
Seq 1-93 Hetero pentamer : IID00700Complex,IID00824Complex
 Evidence X-RAY 4drw B Reference
       Region 4drw B 1-1 disorder
       Region 4drw B 2-92 order
       Region 4drw B 93-93 disorder
 Evidence X-RAY 4drw A Reference
       Region 4drw A 1-1 disorder
       Region 4drw A 2-92 order
       Region 4drw A 93-93 disorder
Seq 1-93 Hetero trimer : IID00700Complex,IID00724Complex
 Evidence X-RAY 4hrh B Reference
       Region 4hrh B 1-1 disorder
       Region 4hrh B 2-93 order
Seq 1-93 Hetero tetramer : IID00824Complex
 Evidence X-RAY 4hrg B Reference
       Region 4hrg B 1-1 disorder
       Region 4hrg B 2-93 order
 Evidence X-RAY 4hrg A Reference
       Region 4hrg A 1-93 order
Seq 1-93 Hetero hexamer : IID00700Complex,IID00724Complex
 Evidence X-RAY 4hrh B Reference
       Region 4hrh B 1-1 disorder
       Region 4hrh B 2-93 order
 Evidence X-RAY 4hrh A Reference
       Region 4hrh A 1-1 disorder
       Region 4hrh A 2-92 order
       Region 4hrh A 93-93 disorder
Seq 2-97 Homo dimer :
 Evidence X-RAY 1a4p B Reference
       Region 1a4p B 2-92 order
       Region 1a4p B 93-97 disorder
 Evidence X-RAY 1a4p A Reference
       Region 1a4p A 2-93 order
       Region 1a4p A 94-97 disorder
Seq 2-97 Hetero pentamer : IID00700Complex,IID00824Complex
 Evidence X-RAY 4ftg B Reference
       Region 4ftg B 2-92 order
       Region 4ftg B 93-97 disorder
 Evidence X-RAY 4ftg A Reference
       Region 4ftg A 2-92 order
       Region 4ftg A 93-97 disorder
Seq 2-97 Hetero hexamer : IID00724Complex,IID50353Complex
 Evidence X-RAY 4hre J Reference
       Region 4hre J 2-92 order
       Region 4hre J 93-97 disorder
 Evidence X-RAY 4hre I Reference
       Region 4hre I 2-92 order
       Region 4hre I 93-97 disorder
Seq 2-97 Hetero tetramer : IID50358Complex
 Evidence X-RAY 1bt6 B Reference
       Region 1bt6 B 2-92 order
       Region 1bt6 B 93-97 disorder
 Evidence X-RAY 1bt6 A Reference
       Region 1bt6 A 2-92 order
       Region 1bt6 A 93-97 disorder
Seq 2-97 Hetero hexamer : IID00724Complex,IID50353Complex
 Evidence X-RAY 4hre F Reference
       Region 4hre F 2-92 order
       Region 4hre F 93-97 disorder
 Evidence X-RAY 4hre E Reference
       Region 4hre E 2-92 order
       Region 4hre E 93-97 disorder
Seqacetylation
    57-57 N6-acetyllysine
    54-54 N6-acetyllysine
    37-37 N6-acetyllysine; alternate
    28-28 N6-acetyllysine
    23-23 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-2,91-97
Order 3-90
ProS 1-2
AlphaFold
Disorder 92-97
Order 1-91
Pfam Hmmer
PF01023 5-45 7e-16
Function
Function in SwissProt
Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.
Biological Process
See also
Diagram with PDB data
ANXA2/S100A10P11 (S100A10), LIGAND OF ANNEXIN II IN COMPLEX WITH ANNEXIN II N-TERMINUS
AHNAK/ANXA2/S100A10The crystal structure of an AHNAK peptide in complex with the S100A10/AnxA2 heterotetramer
HLTF/S100A10/ANXA2Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with SMARCA3 Peptide