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IID00816
 UniprotP61981
Protein14-3-3 protein gamma
GeneYWHAG
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
247
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-234 Hetero tetradecamer : IID00803Complex
 Evidence X-RAY 6gkg H Reference
       Region 6gkg H 1-1 disorder
       Region 6gkg H 2-200 order
       Region 6gkg H 201-215 disorder
       Region 6gkg H 216-232 order
       Region 6gkg H 233-234 disorder
 Evidence X-RAY 6gkg G Reference
       Region 6gkg G 1-1 disorder
       Region 6gkg G 2-70 order
       Region 6gkg G 71-76 disorder
       Region 6gkg G 77-208 order
       Region 6gkg G 209-215 disorder
       Region 6gkg G 216-234 order
 Evidence X-RAY 6gkg F Reference
       Region 6gkg F 1-1 disorder
       Region 6gkg F 2-71 order
       Region 6gkg F 72-73 disorder
       Region 6gkg F 74-209 order
       Region 6gkg F 210-214 disorder
       Region 6gkg F 215-234 order
 Evidence X-RAY 6gkg E Reference
       Region 6gkg E 1-1 disorder
       Region 6gkg E 2-234 order
 Evidence X-RAY 6gkg D Reference
       Region 6gkg D 1-1 disorder
       Region 6gkg D 2-70 order
       Region 6gkg D 71-76 disorder
       Region 6gkg D 77-208 order
       Region 6gkg D 209-215 disorder
       Region 6gkg D 216-234 order
 Evidence X-RAY 6gkg C Reference
       Region 6gkg C 1-3 disorder
       Region 6gkg C 4-234 order
 Evidence X-RAY 6gkg B Reference
       Region 6gkg B 1-1 disorder
       Region 6gkg B 2-234 order
 Evidence X-RAY 6gkg A Reference
       Region 6gkg A 1-1 disorder
       Region 6gkg A 2-234 order
Seq 1-234 Hetero octamer : IID00889Complex
 Evidence X-RAY 7a6y D Reference
       Region 7a6y D 1-3 disorder
       Region 7a6y D 4-139 order
       Region 7a6y D 140-141 disorder
       Region 7a6y D 142-234 order
 Evidence X-RAY 7a6y C Reference
       Region 7a6y C 1-1 disorder
       Region 7a6y C 2-208 order
       Region 7a6y C 209-215 disorder
       Region 7a6y C 216-233 order
       Region 7a6y C 234-234 disorder
 Evidence X-RAY 7a6y B Reference
       Region 7a6y B 1-2 disorder
       Region 7a6y B 3-69 order
       Region 7a6y B 70-78 disorder
       Region 7a6y B 79-210 order
       Region 7a6y B 211-216 disorder
       Region 7a6y B 217-234 order
 Evidence X-RAY 7a6y A Reference
       Region 7a6y A 1-1 disorder
       Region 7a6y A 2-70 order
       Region 7a6y A 71-73 disorder
       Region 7a6y A 74-211 order
       Region 7a6y A 212-215 disorder
       Region 7a6y A 216-234 order
 Evidence X-RAY 7a6r D Reference
       Region 7a6r D 1-2 disorder
       Region 7a6r D 3-234 order
 Evidence X-RAY 7a6r C Reference
       Region 7a6r C 1-1 disorder
       Region 7a6r C 2-234 order
 Evidence X-RAY 7a6r B Reference
       Region 7a6r B 1-1 disorder
       Region 7a6r B 2-70 order
       Region 7a6r B 71-77 disorder
       Region 7a6r B 78-210 order
       Region 7a6r B 211-214 disorder
       Region 7a6r B 215-234 order
 Evidence X-RAY 7a6r A Reference
       Region 7a6r A 1-3 disorder
       Region 7a6r A 4-70 order
       Region 7a6r A 71-74 disorder
       Region 7a6r A 75-234 order
Seq 1-234 Hetero octamer : IID00114Complex
 Evidence X-RAY 6zc9 D Reference
       Region 6zc9 D 1-2 disorder
       Region 6zc9 D 3-234 order
 Evidence X-RAY 6zc9 C Reference
       Region 6zc9 C 1-2 disorder
       Region 6zc9 C 3-70 order
       Region 6zc9 C 71-72 disorder
       Region 6zc9 C 73-234 order
 Evidence X-RAY 6zc9 B Reference
       Region 6zc9 B 1-2 disorder
       Region 6zc9 B 3-70 order
       Region 6zc9 B 71-77 disorder
       Region 6zc9 B 78-234 order
 Evidence X-RAY 6zc9 A Reference
       Region 6zc9 A 1-2 disorder
       Region 6zc9 A 3-69 order
       Region 6zc9 A 70-71 disorder
       Region 6zc9 A 72-234 order
Seq 1-234 Hetero trimer : IID00803Complex
 Evidence X-RAY 6sad B Reference
       Region 6sad B 1-1 disorder
       Region 6sad B 2-234 order
 Evidence X-RAY 6sad A Reference
       Region 6sad A 1-1 disorder
       Region 6sad A 2-234 order
Seq 1-234 Hetero dimer : IID00803Complex
 Evidence X-RAY 6s9k A Reference
       Region 6s9k A 1-1 disorder
       Region 6s9k A 2-70 order
       Region 6s9k A 71-75 disorder
       Region 6s9k A 76-234 order
Seq 1-234 Hetero tetramer : IID00866Complex
 Evidence X-RAY 6fel A Reference
       Region 6fel A 1-1 disorder
       Region 6fel A 2-211 order
       Region 6fel A 212-215 disorder
       Region 6fel A 216-234 order
 Evidence X-RAY 6fel B Reference
       Region 6fel B 1-2 disorder
       Region 6fel B 3-68 order
       Region 6fel B 69-76 disorder
       Region 6fel B 77-211 order
       Region 6fel B 212-214 disorder
       Region 6fel B 215-233 order
       Region 6fel B 234-234 disorder
 Evidence X-RAY 6fel C Reference
       Region 6fel C 1-1 disorder
       Region 6fel C 2-208 order
       Region 6fel C 209-215 disorder
       Region 6fel C 216-233 order
       Region 6fel C 234-234 disorder
 Evidence X-RAY 6fel D Reference
       Region 6fel D 1-2 disorder
       Region 6fel D 3-69 order
       Region 6fel D 70-73 disorder
       Region 6fel D 74-234 order
Seq 1-234 Hetero hexadecamer : IID00803Complex
 Evidence X-RAY 6gkf H Reference
       Region 6gkf H 1-1 disorder
       Region 6gkf H 2-70 order
       Region 6gkf H 71-76 disorder
       Region 6gkf H 77-208 order
       Region 6gkf H 209-215 disorder
       Region 6gkf H 216-234 order
 Evidence X-RAY 6gkf G Reference
       Region 6gkf G 1-1 disorder
       Region 6gkf G 2-110 order
       Region 6gkf G 111-114 disorder
       Region 6gkf G 115-207 order
       Region 6gkf G 208-219 disorder
       Region 6gkf G 220-234 order
 Evidence X-RAY 6gkf F Reference
       Region 6gkf F 1-1 disorder
       Region 6gkf F 2-71 order
       Region 6gkf F 72-75 disorder
       Region 6gkf F 76-110 order
       Region 6gkf F 111-115 disorder
       Region 6gkf F 116-164 order
       Region 6gkf F 165-166 disorder
       Region 6gkf F 167-207 order
       Region 6gkf F 208-214 disorder
       Region 6gkf F 215-232 order
       Region 6gkf F 233-234 disorder
 Evidence X-RAY 6gkf E Reference
       Region 6gkf E 1-1 disorder
       Region 6gkf E 2-234 order
 Evidence X-RAY 6gkf D Reference
       Region 6gkf D 1-1 disorder
       Region 6gkf D 2-113 order
       Region 6gkf D 114-115 disorder
       Region 6gkf D 116-211 order
       Region 6gkf D 212-215 disorder
       Region 6gkf D 216-234 order
 Evidence X-RAY 6gkf C Reference
       Region 6gkf C 1-1 disorder
       Region 6gkf C 2-73 order
       Region 6gkf C 74-75 disorder
       Region 6gkf C 76-109 order
       Region 6gkf C 110-112 disorder
       Region 6gkf C 113-234 order
 Evidence X-RAY 6gkf B Reference
       Region 6gkf B 1-1 disorder
       Region 6gkf B 2-109 order
       Region 6gkf B 110-115 disorder
       Region 6gkf B 116-234 order
 Evidence X-RAY 6gkf A Reference
       Region 6gkf A 1-2 disorder
       Region 6gkf A 3-70 order
       Region 6gkf A 71-74 disorder
       Region 6gkf A 75-110 order
       Region 6gkf A 111-115 disorder
       Region 6gkf A 116-234 order
Seq 1-234 Hetero octamer : IID00114Complex
 Evidence X-RAY 6zbt D Reference
       Region 6zbt D 1-2 disorder
       Region 6zbt D 3-71 order
       Region 6zbt D 72-74 disorder
       Region 6zbt D 75-234 order
 Evidence X-RAY 6zbt C Reference
       Region 6zbt C 1-2 disorder
       Region 6zbt C 3-70 order
       Region 6zbt C 71-73 disorder
       Region 6zbt C 74-211 order
       Region 6zbt C 212-213 disorder
       Region 6zbt C 214-234 order
 Evidence X-RAY 6zbt B Reference
       Region 6zbt B 1-2 disorder
       Region 6zbt B 3-70 order
       Region 6zbt B 71-75 disorder
       Region 6zbt B 76-234 order
 Evidence X-RAY 6zbt A Reference
       Region 6zbt A 1-2 disorder
       Region 6zbt A 3-234 order
Seq 1-234 Hetero tetramer : IID00866Complex
 Evidence X-RAY 6y6b B Reference
       Region 6y6b B 1-1 disorder
       Region 6y6b B 2-234 order
 Evidence X-RAY 6y6b A Reference
       Region 6y6b A 1-1 disorder
       Region 6y6b A 2-70 order
       Region 6y6b A 71-76 disorder
       Region 6y6b A 77-233 order
       Region 6y6b A 234-234 disorder
 Evidence X-RAY 6y4k B Reference
       Region 6y4k B 1-1 disorder
       Region 6y4k B 2-70 order
       Region 6y4k B 71-76 disorder
       Region 6y4k B 77-207 order
       Region 6y4k B 208-218 disorder
       Region 6y4k B 219-234 order
 Evidence X-RAY 6y4k A Reference
       Region 6y4k A 1-2 disorder
       Region 6y4k A 3-70 order
       Region 6y4k A 71-75 disorder
       Region 6y4k A 76-233 order
       Region 6y4k A 234-234 disorder
Seq 1-238 Hetero trimer : IID00540Complex
 Evidence X-RAY 5d3e J Reference
       Region 5d3e J 1-2 disorder
       Region 5d3e J 3-207 order
       Region 5d3e J 208-215 disorder
       Region 5d3e J 216-234 order
       Region 5d3e J 235-238 disorder
 Evidence X-RAY 5d3e I Reference
       Region 5d3e I 1-1 disorder
       Region 5d3e I 2-236 order
       Region 5d3e I 237-238 disorder
Seq 1-238 Hetero trimer : IID00540Complex
 Evidence X-RAY 5d3e A Reference
       Region 5d3e A 1-1 disorder
       Region 5d3e A 2-236 order
       Region 5d3e A 237-238 disorder
 Evidence X-RAY 5d3e B Reference
       Region 5d3e B 1-235 order
       Region 5d3e B 236-238 disorder
 Evidence X-RAY 5d3e E Reference
       Region 5d3e E 1-1 disorder
       Region 5d3e E 2-235 order
       Region 5d3e E 236-238 disorder
 Evidence X-RAY 5d3e F Reference
       Region 5d3e F 1-235 order
       Region 5d3e F 236-238 disorder
Seq 1-247 Hetero octamer :
 Evidence X-RAY 6a5s G Reference
       Region 6a5s G 1-2 disorder
       Region 6a5s G 3-70 order
       Region 6a5s G 71-75 disorder
       Region 6a5s G 76-235 order
       Region 6a5s G 236-247 disorder
 Evidence X-RAY 6a5s D Reference
       Region 6a5s D 1-2 disorder
       Region 6a5s D 3-235 order
       Region 6a5s D 236-247 disorder
 Evidence X-RAY 6a5s B Reference
       Region 6a5s B 1-2 disorder
       Region 6a5s B 3-70 order
       Region 6a5s B 71-74 disorder
       Region 6a5s B 75-235 order
       Region 6a5s B 236-247 disorder
 Evidence X-RAY 6a5s A Reference
       Region 6a5s A 1-1 disorder
       Region 6a5s A 2-70 order
       Region 6a5s A 71-74 disorder
       Region 6a5s A 75-235 order
       Region 6a5s A 236-247 disorder
Seq 1-247 Homo tetramer :
 Evidence X-RAY 4e2e A Reference
       Region 4e2e A 1-235 order
       Region 4e2e A 236-247 disorder
Seq 1-247 Hetero dimer : IID00771Complex
 Evidence X-RAY 4j6s A Reference
       Region 4j6s A 1-236 order
       Region 4j6s A 237-247 disorder
 Evidence X-RAY 4j6s B Reference
       Region 4j6s B 1-239 order
       Region 4j6s B 240-247 disorder
 Evidence X-RAY 4j6s C Reference
       Region 4j6s C 1-235 order
       Region 4j6s C 236-247 disorder
 Evidence X-RAY 4j6s D Reference
       Region 4j6s D 1-236 order
       Region 4j6s D 237-247 disorder
Seq 1-247 Homo dimer :
 Evidence X-RAY 4e2e A Reference
       Region 4e2e A 1-235 order
       Region 4e2e A 236-247 disorder
Seq 1-247 Hetero dodecamer : Q9YP60
 Evidence X-RAY 4o46 F Reference
       Region 4o46 F 1-1 disorder
       Region 4o46 F 2-73 order
       Region 4o46 F 74-76 disorder
       Region 4o46 F 77-115 order
       Region 4o46 F 116-117 disorder
       Region 4o46 F 118-137 order
       Region 4o46 F 138-141 disorder
       Region 4o46 F 142-161 order
       Region 4o46 F 162-170 disorder
       Region 4o46 F 171-204 order
       Region 4o46 F 205-214 disorder
       Region 4o46 F 215-235 order
       Region 4o46 F 236-247 disorder
 Evidence X-RAY 4o46 E Reference
       Region 4o46 E 1-1 disorder
       Region 4o46 E 2-237 order
       Region 4o46 E 238-247 disorder
 Evidence X-RAY 4o46 D Reference
       Region 4o46 D 1-235 order
       Region 4o46 D 236-247 disorder
 Evidence X-RAY 4o46 C Reference
       Region 4o46 C 1-235 order
       Region 4o46 C 236-247 disorder
 Evidence X-RAY 4o46 B Reference
       Region 4o46 B 1-1 disorder
       Region 4o46 B 2-235 order
       Region 4o46 B 236-247 disorder
 Evidence X-RAY 4o46 A Reference
       Region 4o46 A 1-1 disorder
       Region 4o46 A 2-236 order
       Region 4o46 A 237-247 disorder
Seq 1-247 Hetero dimer : IID00457Complex
 Evidence X-RAY 3uzd A Reference
       Region 3uzd A 1-1 disorder
       Region 3uzd A 2-71 order
       Region 3uzd A 72-74 disorder
       Region 3uzd A 75-76 order
       Region 3uzd A 77-77 disorder
       Region 3uzd A 78-234 order
       Region 3uzd A 235-247 disorder
Seq 2-241 Hetero nonamer :
 Evidence X-RAY 6byj F Reference
       Region 6byj F 2-2 disorder
       Region 6byj F 3-234 order
       Region 6byj F 235-241 disorder
 Evidence X-RAY 6byj E Reference
       Region 6byj E 2-238 order
       Region 6byj E 239-241 disorder
 Evidence X-RAY 6byj D Reference
       Region 6byj D 2-239 order
       Region 6byj D 240-241 disorder
 Evidence X-RAY 6byj C Reference
       Region 6byj C 2-239 order
       Region 6byj C 240-241 disorder
 Evidence X-RAY 6byj B Reference
       Region 6byj B 2-239 order
       Region 6byj B 240-241 disorder
 Evidence X-RAY 6byj A Reference
       Region 6byj A 2-241 order
Seq 2-241 Hetero nonamer :
 Evidence X-RAY 6byl F Reference
       Region 6byl F 2-2 disorder
       Region 6byl F 3-234 order
       Region 6byl F 235-241 disorder
 Evidence X-RAY 6byl E Reference
       Region 6byl E 2-238 order
       Region 6byl E 239-241 disorder
 Evidence X-RAY 6byl D Reference
       Region 6byl D 2-239 order
       Region 6byl D 240-241 disorder
 Evidence X-RAY 6byl C Reference
       Region 6byl C 2-239 order
       Region 6byl C 240-241 disorder
 Evidence X-RAY 6byl B Reference
       Region 6byl B 2-238 order
       Region 6byl B 239-241 disorder
 Evidence X-RAY 6byl A Reference
       Region 6byl A 2-241 order
Seq 2-247 Hetero tetramer :
 Evidence X-RAY 2b05 D Reference
       Region 2b05 D 2-234 order
       Region 2b05 D 235-247 disorder
 Evidence X-RAY 2b05 A Reference
       Region 2b05 A 2-234 order
       Region 2b05 A 235-247 disorder
Seq 2-247 Hetero tetramer :
 Evidence X-RAY 2b05 C Reference
       Region 2b05 C 2-234 order
       Region 2b05 C 235-247 disorder
 Evidence X-RAY 2b05 B Reference
       Region 2b05 B 2-234 order
       Region 2b05 B 235-247 disorder
Seq 2-247 Hetero tetramer :
 Evidence X-RAY 2b05 F Reference
       Region 2b05 F 2-2 disorder
       Region 2b05 F 3-234 order
       Region 2b05 F 235-247 disorder
 Evidence X-RAY 2b05 E Reference
       Region 2b05 E 2-3 disorder
       Region 2b05 E 4-234 order
       Region 2b05 E 235-247 disorder
Seq 2-247 Hetero hexamer :
 Evidence X-RAY 6bzd D Reference
       Region 6bzd D 2-73 order
       Region 6bzd D 74-77 disorder
       Region 6bzd D 78-238 order
       Region 6bzd D 239-247 disorder
 Evidence X-RAY 6bzd C Reference
       Region 6bzd C 2-238 order
       Region 6bzd C 239-247 disorder
 Evidence X-RAY 6bzd B Reference
       Region 6bzd B 2-238 order
       Region 6bzd B 239-247 disorder
 Evidence X-RAY 6bzd A Reference
       Region 6bzd A 2-239 order
       Region 6bzd A 240-247 disorder
Seqphosphorylation
    235-235 Phosphoserine
    71-71 Phosphoserine
    133-133 Phosphotyrosine
    145-145 Phosphothreonine
    215-215 Phosphoserine
    234-234 Phosphothreonine
Seqacetylation
    1-1 N-acetylmethionine; in 14-3-3 protein gamma; alternate; partial
    2-2 N-acetylvaline; in 14-3-3 protein gamma
    2-2 N-acetylvaline; partial
 
Prediction
NeProc
Disorder 1-4,237-247
Order 5-236
ProS 237-247
AlphaFold
Disorder 1-1,240-247
Order 2-239
Pfam Hmmer
PF00244 4-241 9.3e-147
SEG 236-243
Function
Function in SwissProt
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624).
Biological Process
See also
Diagram with PDB data
CFTR/YWHAZCrystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768
HDAC4/YWHAGCrystal structure of 14-3-3 GAMMA