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IID00818
 UniprotP80192
ProteinMitogen-activated protein kinase kinase kinase 9
GeneMAP3K9
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1104
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 135-456 Homo tetramer :
 Evidence X-RAY 4uy9 B Reference
       Region 4uy9 B 135-449 order
       Region 4uy9 B 450-456 disorder
 Evidence X-RAY 4uy9 A Reference
       Region 4uy9 A 135-447 order
       Region 4uy9 A 448-456 disorder
Seq 136-406 Monomer :
 Evidence X-RAY 3dtc A Reference
       Region 3dtc A 136-173 order
       Region 3dtc A 174-183 disorder
       Region 3dtc A 184-213 order
       Region 3dtc A 214-215 disorder
       Region 3dtc A 216-297 order
       Region 3dtc A 298-310 disorder
       Region 3dtc A 311-405 order
       Region 3dtc A 406-406 disorder
Seqphosphorylation
    304-304 Phosphothreonine; by autocatalysis
    305-305 Phosphothreonine; by autocatalysis
    308-308 Phosphoserine; by autocatalysis
    312-312 Phosphothreonine; by autocatalysis
    533-533 Phosphoserine
 
Prediction
NeProc
Disorder 1-52,118-133,484-1092,1095-1104
Order 53-117,134-483,1093-1094
ProS 6-12,19-23,484-530,557-577,588-601,636-656,680-685,697-721,748-756,765-771,794-801,829-850,877-882,898-901,909-921,931-944,955-967,988-1009,1054-1057,1065-1092,1095-1104
AlphaFold
Disorder 1-54,114-135,153-155,296-311,493-528,530-757,763-1104
Order 55-113,136-152,156-295,312-492,529-529,758-762
Pfam Hmmer
PF00018 55-114 2.9e-15
PF00069 144-403 1.4e-94
SEG 6-49 ,456-476 ,580-597 ,673-688 ,752-766 ,777-795 ,800-813 ,829-841 ,929-944
Function
Function in SwissProt
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.