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IID00821
 UniprotQ04917
Protein14-3-3 protein eta
GeneYWHAH
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
246
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2-246 Hetero tetramer :
 Evidence X-RAY 2c63 B Reference
       Region 2c63 B 2-2 disorder
       Region 2c63 B 3-235 order
       Region 2c63 B 236-246 disorder
 Evidence X-RAY 2c63 A Reference
       Region 2c63 A 2-2 disorder
       Region 2c63 A 3-235 order
       Region 2c63 A 236-246 disorder
Seq 2-246 Hetero tetramer :
 Evidence X-RAY 2c74 B Reference
       Region 2c74 B 2-235 order
       Region 2c74 B 236-246 disorder
 Evidence X-RAY 2c74 A Reference
       Region 2c74 A 2-236 order
       Region 2c74 A 237-246 disorder
Seq 2-246 Hetero tetramer :
 Evidence X-RAY 2c63 D Reference
       Region 2c63 D 2-2 disorder
       Region 2c63 D 3-235 order
       Region 2c63 D 236-246 disorder
 Evidence X-RAY 2c63 C Reference
       Region 2c63 C 2-2 disorder
       Region 2c63 C 3-235 order
       Region 2c63 C 236-246 disorder
Seqphosphorylation
    59-59 Phosphoserine
    25-25 Phosphoserine
Seqacetylation
    2-2 N-acetylglycine
 
Prediction
NeProc
Disorder 1-3,236-246
Order 4-235
ProS 236-246
AlphaFold
Disorder 1-1,242-246
Order 2-241
Pfam Hmmer
PF00244 4-241 6.3e-147
Function
Function in SwissProt
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.