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IID00822
 UniprotQ07864
ProteinDNA polymerase epsilon catalytic subunit A
GenePOLE
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
2286
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2142-2286 Hetero dimer : P56282
 Evidence X-RAY 5vbn F Reference
       Region 5vbn F 2142-2149 disorder
       Region 5vbn F 2150-2174 order
       Region 5vbn F 2175-2182 disorder
       Region 5vbn F 2183-2282 order
       Region 5vbn F 2283-2286 disorder
 Evidence X-RAY 5vbn B Reference
       Region 5vbn B 2142-2149 disorder
       Region 5vbn B 2150-2174 order
       Region 5vbn B 2175-2182 disorder
       Region 5vbn B 2183-2282 order
       Region 5vbn B 2283-2286 disorder
Seqphosphorylation
    1317-1317 Phosphoserine
    1297-1297 Phosphoserine
    1184-1184 Phosphoserine
    1940-1940 Phosphoserine
 
Prediction
NeProc
Disorder 1-29,195-209,1189-1271,1287-1320,1762-1784,1936-1945,2017-2045,2285-2286
Order 30-194,210-1188,1272-1286,1321-1470,1475-1761,1790-1935,1946-2016,2046-2284
ProS 5-23,195-205,1189-1197,1209-1215,1226-1234,1250-1271,1287-1298,1316-1320,1766-1774,1779-1784,2023-2030,2285-2286
AlphaFold
Disorder 1-30,181-212,252-252,418-420,659-659,976-977,1071-1073,1174-1254,1260-1263,1265-1265,1287-1323,1376-1377,1379-1379,1451-1461,1614-1618,1621-1621,1703-1714,1744-1786,1929-1973,2014-2045,2075-2085,2173-2183,2282-2286
Order 31-180,213-251,253-417,421-658,660-975,978-1070,1074-1173,1255-1259,1264-1264,1266-1286,1324-1375,1378-1378,1380-1450,1462-1613,1619-1620,1622-1702,1715-1743,1787-1928,1974-2013,2046-2074,2086-2172,2184-2281
Pfam Hmmer
PF03104 86-427 3.5e-135
PF00136 496-1161 2.6e-05
PF08490 1525-1925 1.4e-250
SEG 4-17 ,1280-1295 ,1947-1977
Function
Function in SwissProt
Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Involved in DNA synthesis during DNA repair (PubMed:20227374, PubMed:27573199). Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374).