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IID00823
 UniprotQ07889
ProteinSon of sevenless homolog 1
GeneSOS1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1333
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-191 Monomer :
 Evidence X-RAY 1q9c A Reference
       Region 1q9c A 1-5 disorder
       Region 1q9c A 6-95 order
       Region 1q9c A 96-103 disorder
       Region 1q9c A 104-177 order
       Region 1q9c A 178-191 disorder
 Evidence X-RAY 1q9c B Reference
       Region 1q9c B 1-6 disorder
       Region 1q9c B 7-178 order
       Region 1q9c B 179-191 disorder
 Evidence X-RAY 1q9c C Reference
       Region 1q9c C 1-9 disorder
       Region 1q9c C 10-95 order
       Region 1q9c C 96-101 disorder
       Region 1q9c C 102-177 order
       Region 1q9c C 178-191 disorder
 Evidence X-RAY 1q9c D Reference
       Region 1q9c D 1-5 disorder
       Region 1q9c D 6-183 order
       Region 1q9c D 184-191 disorder
 Evidence X-RAY 1q9c E Reference
       Region 1q9c E 1-5 disorder
       Region 1q9c E 6-96 order
       Region 1q9c E 97-98 disorder
       Region 1q9c E 99-183 order
       Region 1q9c E 184-191 disorder
 Evidence X-RAY 1q9c F Reference
       Region 1q9c F 1-5 disorder
       Region 1q9c F 6-97 order
       Region 1q9c F 98-101 disorder
       Region 1q9c F 102-183 order
       Region 1q9c F 184-191 disorder
 Evidence X-RAY 1q9c G Reference
       Region 1q9c G 1-5 disorder
       Region 1q9c G 6-179 order
       Region 1q9c G 180-191 disorder
 Evidence X-RAY 1q9c H Reference
       Region 1q9c H 1-5 disorder
       Region 1q9c H 6-99 order
       Region 1q9c H 100-102 disorder
       Region 1q9c H 103-183 order
       Region 1q9c H 184-191 disorder
 Evidence X-RAY 1q9c I Reference
       Region 1q9c I 1-5 disorder
       Region 1q9c I 6-183 order
       Region 1q9c I 184-191 disorder
Seq 1-1049 Monomer :
 Evidence X-RAY 3ksy A Reference
       Region 3ksy A 1-5 disorder
       Region 3ksy A 6-177 order
       Region 3ksy A 178-194 disorder
       Region 3ksy A 195-404 order
       Region 3ksy A 405-417 disorder
       Region 3ksy A 418-746 order
       Region 3ksy A 747-749 disorder
       Region 3ksy A 750-1045 order
       Region 3ksy A 1046-1049 disorder
 Evidence X-RAY 1xd4 A Reference
       Region 1xd4 A 198-404 order
       Region 1xd4 A 405-417 disorder
       Region 1xd4 A 418-590 order
       Region 1xd4 A 591-596 disorder
       Region 1xd4 A 597-743 order
       Region 1xd4 A 744-749 disorder
       Region 1xd4 A 750-1046 order
       Region 1xd4 A 1047-1049 disorder
 Evidence X-RAY 1xd4 B Reference
       Region 1xd4 B 198-404 order
       Region 1xd4 B 405-417 disorder
       Region 1xd4 B 418-590 order
       Region 1xd4 B 591-596 disorder
       Region 1xd4 B 597-743 order
       Region 1xd4 B 744-749 disorder
       Region 1xd4 B 750-1046 order
       Region 1xd4 B 1047-1049 disorder
 Evidence X-RAY 1xdv A Reference
       Region 1xdv A 198-199 disorder
       Region 1xdv A 200-404 order
       Region 1xdv A 405-418 disorder
       Region 1xdv A 419-474 order
       Region 1xdv A 475-486 disorder
       Region 1xdv A 487-549 order
       Region 1xdv A 550-567 disorder
       Region 1xdv A 568-590 order
       Region 1xdv A 591-596 disorder
       Region 1xdv A 597-653 order
       Region 1xdv A 654-675 disorder
       Region 1xdv A 676-741 order
       Region 1xdv A 742-756 disorder
       Region 1xdv A 757-1044 order
 Evidence X-RAY 1xdv B Reference
       Region 1xdv B 198-199 disorder
       Region 1xdv B 200-404 order
       Region 1xdv B 405-418 disorder
       Region 1xdv B 419-474 order
       Region 1xdv B 475-486 disorder
       Region 1xdv B 487-550 order
       Region 1xdv B 551-567 disorder
       Region 1xdv B 568-590 order
       Region 1xdv B 591-596 disorder
       Region 1xdv B 597-653 order
       Region 1xdv B 654-675 disorder
       Region 1xdv B 676-741 order
       Region 1xdv B 742-756 disorder
       Region 1xdv B 757-1044 order
Seq 198-551 Monomer :
 Evidence X-RAY 1dbh A Reference
       Region 1dbh A 198-404 order
       Region 1dbh A 405-417 disorder
       Region 1dbh A 418-550 order
       Region 1dbh A 551-551 disorder
Seq 422-551 Monomer :
 Evidence NMR 1awe A Reference
       Region 1awe A 422-551 order
       Region 1awe A 476-484 high_rmsd
Seq 560-1049 Monomer :
 Evidence X-RAY 2ii0 A Reference
       Region 2ii0 A 564-565 disorder
       Region 2ii0 A 566-589 order
       Region 2ii0 A 590-596 disorder
       Region 2ii0 A 597-743 order
       Region 2ii0 A 744-753 disorder
       Region 2ii0 A 754-1045 order
       Region 2ii0 A 1046-1049 disorder
 Evidence X-RAY 7avv A Reference
       Region 7avv A 564-564 disorder
       Region 7avv A 565-589 order
       Region 7avv A 590-596 disorder
       Region 7avv A 597-658 order
       Region 7avv A 659-668 disorder
       Region 7avv A 669-743 order
       Region 7avv A 744-753 disorder
       Region 7avv A 754-808 order
       Region 7avv A 809-814 disorder
       Region 7avv A 815-1042 order
       Region 7avv A 1043-1049 disorder
 Evidence X-RAY 5ovd A Reference
       Region 5ovd A 560-590 order
       Region 5ovd A 591-596 disorder
       Region 5ovd A 597-662 order
       Region 5ovd A 663-668 disorder
       Region 5ovd A 669-744 order
       Region 5ovd A 745-752 disorder
       Region 5ovd A 753-1044 order
       Region 5ovd A 1045-1049 disorder
 Evidence X-RAY 5ove A Reference
       Region 5ove A 560-590 order
       Region 5ove A 591-596 disorder
       Region 5ove A 597-745 order
       Region 5ove A 746-752 disorder
       Region 5ove A 753-1044 order
       Region 5ove A 1045-1049 disorder
 Evidence X-RAY 5ovf A Reference
       Region 5ovf A 560-590 order
       Region 5ovf A 591-596 disorder
       Region 5ovf A 597-745 order
       Region 5ovf A 746-753 disorder
       Region 5ovf A 754-1045 order
       Region 5ovf A 1046-1049 disorder
 Evidence X-RAY 5ovg A Reference
       Region 5ovg A 560-562 disorder
       Region 5ovg A 563-590 order
       Region 5ovg A 591-596 disorder
       Region 5ovg A 597-656 order
       Region 5ovg A 657-670 disorder
       Region 5ovg A 671-745 order
       Region 5ovg A 746-752 disorder
       Region 5ovg A 753-1044 order
       Region 5ovg A 1045-1049 disorder
 Evidence X-RAY 5ovh A Reference
       Region 5ovh A 560-589 order
       Region 5ovh A 590-595 disorder
       Region 5ovh A 596-652 order
       Region 5ovh A 653-671 disorder
       Region 5ovh A 672-745 order
       Region 5ovh A 746-751 disorder
       Region 5ovh A 752-1045 order
       Region 5ovh A 1046-1049 disorder
 Evidence X-RAY 5ovi A Reference
       Region 5ovi A 560-565 disorder
       Region 5ovi A 566-590 order
       Region 5ovi A 591-596 disorder
       Region 5ovi A 597-745 order
       Region 5ovi A 746-752 disorder
       Region 5ovi A 753-1044 order
       Region 5ovi A 1045-1049 disorder
 Evidence X-RAY 6scm A Reference
       Region 6scm A 564-592 order
       Region 6scm A 593-597 disorder
       Region 6scm A 598-743 order
       Region 6scm A 744-749 disorder
       Region 6scm A 750-1043 order
       Region 6scm A 1044-1049 disorder
 Evidence X-RAY 7uks A Reference
       Region 7uks A 564-566 disorder
       Region 7uks A 567-589 order
       Region 7uks A 590-597 disorder
       Region 7uks A 598-746 order
       Region 7uks A 747-752 disorder
       Region 7uks A 753-1044 order
       Region 7uks A 1045-1049 disorder
Seq 563-1049 Hetero dimer : P01116
 Evidence X-RAY 6epl S Reference
       Region 6epl S 563-564 disorder
       Region 6epl S 565-659 order
       Region 6epl S 660-670 disorder
       Region 6epl S 671-743 order
       Region 6epl S 744-752 disorder
       Region 6epl S 753-1046 order
       Region 6epl S 1047-1049 disorder
 Evidence X-RAY 6epm S Reference
       Region 6epm S 563-564 disorder
       Region 6epm S 565-658 order
       Region 6epm S 659-670 disorder
       Region 6epm S 671-743 order
       Region 6epm S 744-751 disorder
       Region 6epm S 752-1046 order
       Region 6epm S 1047-1049 disorder
 Evidence X-RAY 6epn S Reference
       Region 6epn S 563-564 disorder
       Region 6epn S 565-658 order
       Region 6epn S 659-670 disorder
       Region 6epn S 671-743 order
       Region 6epn S 744-751 disorder
       Region 6epn S 752-1046 order
       Region 6epn S 1047-1049 disorder
 Evidence X-RAY 6epo S Reference
       Region 6epo S 563-564 disorder
       Region 6epo S 565-653 order
       Region 6epo S 654-670 disorder
       Region 6epo S 671-743 order
       Region 6epo S 744-751 disorder
       Region 6epo S 752-1046 order
       Region 6epo S 1047-1049 disorder
 Evidence X-RAY 6epp S Reference
       Region 6epp S 563-564 disorder
       Region 6epp S 565-655 order
       Region 6epp S 656-670 disorder
       Region 6epp S 671-743 order
       Region 6epp S 744-751 disorder
       Region 6epp S 752-1046 order
       Region 6epp S 1047-1049 disorder
Seq 564-1049 Homo dimer :
 Evidence X-RAY 7avi A Reference
       Region 7avi A 564-592 order
       Region 7avi A 593-596 disorder
       Region 7avi A 597-746 order
       Region 7avi A 747-752 disorder
       Region 7avi A 753-1044 order
       Region 7avi A 1045-1049 disorder
 Evidence X-RAY 7avi B Reference
       Region 7avi B 564-592 order
       Region 7avi B 593-596 disorder
       Region 7avi B 597-746 order
       Region 7avi B 747-752 disorder
       Region 7avi B 753-1044 order
       Region 7avi B 1045-1049 disorder
 Evidence X-RAY 7avl A Reference
       Region 7avl A 564-592 order
       Region 7avl A 593-596 disorder
       Region 7avl A 597-746 order
       Region 7avl A 747-752 disorder
       Region 7avl A 753-1044 order
       Region 7avl A 1045-1049 disorder
 Evidence X-RAY 7avl B Reference
       Region 7avl B 564-564 disorder
       Region 7avl B 565-592 order
       Region 7avl B 593-595 disorder
       Region 7avl B 596-744 order
       Region 7avl B 745-753 disorder
       Region 7avl B 754-1042 order
       Region 7avl B 1043-1049 disorder
 Evidence X-RAY 7avs A Reference
       Region 7avs A 564-589 order
       Region 7avs A 590-596 disorder
       Region 7avs A 597-745 order
       Region 7avs A 746-752 disorder
       Region 7avs A 753-1042 order
       Region 7avs A 1043-1049 disorder
 Evidence X-RAY 7avs B Reference
       Region 7avs B 564-564 disorder
       Region 7avs B 565-589 order
       Region 7avs B 590-596 disorder
       Region 7avs B 597-744 order
       Region 7avs B 745-753 disorder
       Region 7avs B 754-1042 order
       Region 7avs B 1043-1049 disorder
 Evidence X-RAY 7avt A Reference
       Region 7avt A 564-589 order
       Region 7avt A 590-596 disorder
       Region 7avt A 597-745 order
       Region 7avt A 746-752 disorder
       Region 7avt A 753-1042 order
       Region 7avt A 1043-1049 disorder
 Evidence X-RAY 7avt B Reference
       Region 7avt B 564-564 disorder
       Region 7avt B 565-589 order
       Region 7avt B 590-596 disorder
       Region 7avt B 597-744 order
       Region 7avt B 745-752 disorder
       Region 7avt B 753-1042 order
       Region 7avt B 1043-1049 disorder
 Evidence X-RAY 7avu A Reference
       Region 7avu A 564-589 order
       Region 7avu A 590-596 disorder
       Region 7avu A 597-745 order
       Region 7avu A 746-752 disorder
       Region 7avu A 753-1042 order
       Region 7avu A 1043-1049 disorder
 Evidence X-RAY 7avu B Reference
       Region 7avu B 564-564 disorder
       Region 7avu B 565-589 order
       Region 7avu B 590-596 disorder
       Region 7avu B 597-744 order
       Region 7avu B 745-752 disorder
       Region 7avu B 753-1042 order
       Region 7avu B 1043-1049 disorder
 Evidence X-RAY 6sfr A Reference
       Region 6sfr A 564-589 order
       Region 6sfr A 590-596 disorder
       Region 6sfr A 597-745 order
       Region 6sfr A 746-752 disorder
       Region 6sfr A 753-1042 order
       Region 6sfr A 1043-1049 disorder
 Evidence X-RAY 6sfr B Reference
       Region 6sfr B 564-564 disorder
       Region 6sfr B 565-589 order
       Region 6sfr B 590-596 disorder
       Region 6sfr B 597-744 order
       Region 6sfr B 745-753 disorder
       Region 6sfr B 754-1042 order
       Region 6sfr B 1043-1049 disorder
 Evidence X-RAY 7ukr A Reference
       Region 7ukr A 564-567 disorder
       Region 7ukr A 568-591 order
       Region 7ukr A 592-598 disorder
       Region 7ukr A 599-651 order
       Region 7ukr A 652-670 disorder
       Region 7ukr A 671-743 order
       Region 7ukr A 744-755 disorder
       Region 7ukr A 756-948 order
       Region 7ukr A 949-955 disorder
       Region 7ukr A 956-1042 order
       Region 7ukr A 1043-1049 disorder
 Evidence X-RAY 7ukr B Reference
       Region 7ukr B 564-575 disorder
       Region 7ukr B 576-589 order
       Region 7ukr B 590-597 disorder
       Region 7ukr B 598-651 order
       Region 7ukr B 652-670 disorder
       Region 7ukr B 671-723 order
       Region 7ukr B 724-725 disorder
       Region 7ukr B 726-743 order
       Region 7ukr B 744-752 disorder
       Region 7ukr B 753-951 order
       Region 7ukr B 952-953 disorder
       Region 7ukr B 954-1042 order
       Region 7ukr B 1043-1049 disorder
Seq 564-1049 Hetero dimer : P01112
 Evidence X-RAY 4uru S Reference
       Region 4uru S 564-566 disorder
       Region 4uru S 567-653 order
       Region 4uru S 654-670 disorder
       Region 4uru S 671-743 order
       Region 4uru S 744-753 disorder
       Region 4uru S 754-1045 order
       Region 4uru S 1046-1049 disorder
 Evidence X-RAY 4urv S Reference
       Region 4urv S 564-567 disorder
       Region 4urv S 568-653 order
       Region 4urv S 654-670 disorder
       Region 4urv S 671-743 order
       Region 4urv S 744-754 disorder
       Region 4urv S 755-1045 order
       Region 4urv S 1046-1049 disorder
 Evidence X-RAY 4urw S Reference
       Region 4urw S 564-565 disorder
       Region 4urw S 566-653 order
       Region 4urw S 654-670 disorder
       Region 4urw S 671-743 order
       Region 4urw S 744-753 disorder
       Region 4urw S 754-1045 order
       Region 4urw S 1046-1049 disorder
 Evidence X-RAY 4urx S Reference
       Region 4urx S 564-565 disorder
       Region 4urx S 566-654 order
       Region 4urx S 655-670 disorder
       Region 4urx S 671-743 order
       Region 4urx S 744-755 disorder
       Region 4urx S 756-1045 order
       Region 4urx S 1046-1049 disorder
 Evidence X-RAY 4ury S Reference
       Region 4ury S 564-565 disorder
       Region 4ury S 566-651 order
       Region 4ury S 652-672 disorder
       Region 4ury S 673-743 order
       Region 4ury S 744-753 disorder
       Region 4ury S 754-1045 order
       Region 4ury S 1046-1049 disorder
 Evidence X-RAY 4urz S Reference
       Region 4urz S 564-566 disorder
       Region 4urz S 567-655 order
       Region 4urz S 656-670 disorder
       Region 4urz S 671-743 order
       Region 4urz S 744-753 disorder
       Region 4urz S 754-1045 order
       Region 4urz S 1046-1049 disorder
 Evidence X-RAY 4us0 S Reference
       Region 4us0 S 564-566 disorder
       Region 4us0 S 567-654 order
       Region 4us0 S 655-670 disorder
       Region 4us0 S 671-743 order
       Region 4us0 S 744-753 disorder
       Region 4us0 S 754-1046 order
       Region 4us0 S 1047-1049 disorder
 Evidence X-RAY 4us1 S Reference
       Region 4us1 S 564-564 disorder
       Region 4us1 S 565-654 order
       Region 4us1 S 655-670 disorder
       Region 4us1 S 671-743 order
       Region 4us1 S 744-753 disorder
       Region 4us1 S 754-1045 order
       Region 4us1 S 1046-1049 disorder
 Evidence X-RAY 4us2 S Reference
       Region 4us2 S 564-565 disorder
       Region 4us2 S 566-653 order
       Region 4us2 S 654-670 disorder
       Region 4us2 S 671-743 order
       Region 4us2 S 744-754 disorder
       Region 4us2 S 755-1046 order
       Region 4us2 S 1047-1049 disorder
 Evidence X-RAY 8be6 S Reference
       Region 8be6 S 564-568 disorder
       Region 8be6 S 569-590 order
       Region 8be6 S 591-596 disorder
       Region 8be6 S 597-653 order
       Region 8be6 S 654-674 disorder
       Region 8be6 S 675-742 order
       Region 8be6 S 743-751 disorder
       Region 8be6 S 752-1044 order
       Region 8be6 S 1045-1049 disorder
 Evidence X-RAY 8be7 S Reference
       Region 8be7 S 564-566 disorder
       Region 8be7 S 567-591 order
       Region 8be7 S 592-596 disorder
       Region 8be7 S 597-653 order
       Region 8be7 S 654-671 disorder
       Region 8be7 S 672-742 order
       Region 8be7 S 743-753 disorder
       Region 8be7 S 754-1019 order
       Region 8be7 S 1020-1022 disorder
       Region 8be7 S 1023-1044 order
       Region 8be7 S 1045-1049 disorder
 Evidence X-RAY 8be8 S Reference
       Region 8be8 S 564-566 disorder
       Region 8be8 S 567-592 order
       Region 8be8 S 593-595 disorder
       Region 8be8 S 596-653 order
       Region 8be8 S 654-671 disorder
       Region 8be8 S 672-742 order
       Region 8be8 S 743-755 disorder
       Region 8be8 S 756-1019 order
       Region 8be8 S 1020-1021 disorder
       Region 8be8 S 1022-1044 order
       Region 8be8 S 1045-1049 disorder
 Evidence X-RAY 8be9 S Reference
       Region 8be9 S 564-566 disorder
       Region 8be9 S 567-592 order
       Region 8be9 S 593-595 disorder
       Region 8be9 S 596-653 order
       Region 8be9 S 654-671 disorder
       Region 8be9 S 672-742 order
       Region 8be9 S 743-753 disorder
       Region 8be9 S 754-1044 order
       Region 8be9 S 1045-1049 disorder
 Evidence X-RAY 8bea S Reference
       Region 8bea S 564-566 disorder
       Region 8bea S 567-653 order
       Region 8bea S 654-671 disorder
       Region 8bea S 672-742 order
       Region 8bea S 743-753 disorder
       Region 8bea S 754-1044 order
       Region 8bea S 1045-1049 disorder
Seq 564-1049 Hetero dimer :
 Evidence X-RAY 8be2 S Reference
       Region 8be2 S 564-566 disorder
       Region 8be2 S 567-590 order
       Region 8be2 S 591-595 disorder
       Region 8be2 S 596-658 order
       Region 8be2 S 659-670 disorder
       Region 8be2 S 671-743 order
       Region 8be2 S 744-754 disorder
       Region 8be2 S 755-1043 order
       Region 8be2 S 1044-1049 disorder
Seq 566-1049 Hetero trimer : P01112
 Evidence X-RAY 1nvu S Reference
       Region 1nvu S 566-590 order
       Region 1nvu S 591-596 disorder
       Region 1nvu S 597-743 order
       Region 1nvu S 744-749 disorder
       Region 1nvu S 750-1046 order
 Evidence X-RAY 1nvv S Reference
       Region 1nvv S 566-590 order
       Region 1nvv S 591-596 disorder
       Region 1nvv S 597-743 order
       Region 1nvv S 744-749 disorder
       Region 1nvv S 750-1046 order
 Evidence X-RAY 1nvw S Reference
       Region 1nvw S 566-590 order
       Region 1nvw S 591-596 disorder
       Region 1nvw S 597-743 order
       Region 1nvw S 744-749 disorder
       Region 1nvw S 750-1046 order
 Evidence X-RAY 1nvx S Reference
       Region 1nvx S 566-590 order
       Region 1nvx S 591-596 disorder
       Region 1nvx S 597-653 order
       Region 1nvx S 654-672 disorder
       Region 1nvx S 673-743 order
       Region 1nvx S 744-749 disorder
       Region 1nvx S 750-1044 order
       Region 1nvx S 1045-1046 disorder
 Evidence X-RAY 4nyj S Reference
       Region 4nyj S 566-590 order
       Region 4nyj S 591-596 disorder
       Region 4nyj S 597-743 order
       Region 4nyj S 744-750 disorder
       Region 4nyj S 751-1046 order
 Evidence X-RAY 4nym S Reference
       Region 4nym S 566-590 order
       Region 4nym S 591-596 disorder
       Region 4nym S 597-743 order
       Region 4nym S 744-749 disorder
       Region 4nym S 750-1046 order
 Evidence X-RAY 1xd2 C Reference
       Region 1xd2 C 566-590 order
       Region 1xd2 C 591-596 disorder
       Region 1xd2 C 597-743 order
       Region 1xd2 C 744-749 disorder
       Region 1xd2 C 750-1046 order
       Region 1xd2 C 1047-1049 disorder
 Evidence X-RAY 6bvi B Reference
       Region 6bvi B 566-590 order
       Region 6bvi B 591-596 disorder
       Region 6bvi B 597-743 order
       Region 6bvi B 744-750 disorder
       Region 6bvi B 751-1046 order
 Evidence X-RAY 6bvj B Reference
       Region 6bvj B 566-590 order
       Region 6bvj B 591-596 disorder
       Region 6bvj B 597-743 order
       Region 6bvj B 744-750 disorder
       Region 6bvj B 751-1046 order
 Evidence X-RAY 6bvk B Reference
       Region 6bvk B 566-590 order
       Region 6bvk B 591-596 disorder
       Region 6bvk B 597-743 order
       Region 6bvk B 744-750 disorder
       Region 6bvk B 751-1046 order
 Evidence X-RAY 6bvl B Reference
       Region 6bvl B 566-590 order
       Region 6bvl B 591-596 disorder
       Region 6bvl B 597-743 order
       Region 6bvl B 744-750 disorder
       Region 6bvl B 751-1046 order
 Evidence X-RAY 6bvm B Reference
       Region 6bvm B 566-590 order
       Region 6bvm B 591-596 disorder
       Region 6bvm B 597-743 order
       Region 6bvm B 744-750 disorder
       Region 6bvm B 751-1046 order
 Evidence X-RAY 6cuo B Reference
       Region 6cuo B 566-590 order
       Region 6cuo B 591-596 disorder
       Region 6cuo B 597-743 order
       Region 6cuo B 744-750 disorder
       Region 6cuo B 751-1046 order
 Evidence X-RAY 6cup B Reference
       Region 6cup B 566-590 order
       Region 6cup B 591-596 disorder
       Region 6cup B 597-743 order
       Region 6cup B 744-750 disorder
       Region 6cup B 751-1046 order
 Evidence X-RAY 6cur B Reference
       Region 6cur B 566-590 order
       Region 6cur B 591-596 disorder
       Region 6cur B 597-743 order
       Region 6cur B 744-750 disorder
       Region 6cur B 751-1046 order
 Evidence X-RAY 6d55 B Reference
       Region 6d55 B 566-590 order
       Region 6d55 B 591-596 disorder
       Region 6d55 B 597-743 order
       Region 6d55 B 744-750 disorder
       Region 6d55 B 751-1046 order
 Evidence X-RAY 6d56 B Reference
       Region 6d56 B 566-590 order
       Region 6d56 B 591-596 disorder
       Region 6d56 B 597-743 order
       Region 6d56 B 744-750 disorder
       Region 6d56 B 751-1046 order
 Evidence X-RAY 6d59 B Reference
       Region 6d59 B 566-590 order
       Region 6d59 B 591-596 disorder
       Region 6d59 B 597-743 order
       Region 6d59 B 744-750 disorder
       Region 6d59 B 751-1046 order
 Evidence X-RAY 6d5e B Reference
       Region 6d5e B 566-590 order
       Region 6d5e B 591-596 disorder
       Region 6d5e B 597-743 order
       Region 6d5e B 744-750 disorder
       Region 6d5e B 751-1046 order
 Evidence X-RAY 6d5g B Reference
       Region 6d5g B 566-590 order
       Region 6d5g B 591-596 disorder
       Region 6d5g B 597-743 order
       Region 6d5g B 744-750 disorder
       Region 6d5g B 751-1046 order
 Evidence X-RAY 6d5h B Reference
       Region 6d5h B 566-590 order
       Region 6d5h B 591-596 disorder
       Region 6d5h B 597-743 order
       Region 6d5h B 744-750 disorder
       Region 6d5h B 751-1046 order
 Evidence X-RAY 6d5j B Reference
       Region 6d5j B 566-590 order
       Region 6d5j B 591-596 disorder
       Region 6d5j B 597-743 order
       Region 6d5j B 744-750 disorder
       Region 6d5j B 751-1046 order
 Evidence X-RAY 6d5l B Reference
       Region 6d5l B 566-590 order
       Region 6d5l B 591-596 disorder
       Region 6d5l B 597-743 order
       Region 6d5l B 744-750 disorder
       Region 6d5l B 751-1046 order
 Evidence X-RAY 6d5m S Reference
       Region 6d5m S 566-590 order
       Region 6d5m S 591-596 disorder
       Region 6d5m S 597-743 order
       Region 6d5m S 744-750 disorder
       Region 6d5m S 751-1046 order
 Evidence X-RAY 6d5v S Reference
       Region 6d5v S 566-590 order
       Region 6d5v S 591-596 disorder
       Region 6d5v S 597-743 order
       Region 6d5v S 744-750 disorder
       Region 6d5v S 751-1045 order
       Region 6d5v S 1046-1046 disorder
 Evidence X-RAY 6d5w S Reference
       Region 6d5w S 566-590 order
       Region 6d5w S 591-596 disorder
       Region 6d5w S 597-743 order
       Region 6d5w S 744-749 disorder
       Region 6d5w S 750-1046 order
 Evidence X-RAY 4nyi S Reference
       Region 4nyi S 566-592 order
       Region 4nyi S 593-595 disorder
       Region 4nyi S 596-743 order
       Region 4nyi S 744-749 disorder
       Region 4nyi S 750-1046 order
 Evidence X-RAY 6v94 B Reference
       Region 6v94 B 566-590 order
       Region 6v94 B 591-596 disorder
       Region 6v94 B 597-743 order
       Region 6v94 B 744-750 disorder
       Region 6v94 B 751-1046 order
 Evidence X-RAY 6v9f B Reference
       Region 6v9f B 566-590 order
       Region 6v9f B 591-596 disorder
       Region 6v9f B 597-743 order
       Region 6v9f B 744-750 disorder
       Region 6v9f B 751-1046 order
 Evidence X-RAY 6v9j B Reference
       Region 6v9j B 566-590 order
       Region 6v9j B 591-596 disorder
       Region 6v9j B 597-743 order
       Region 6v9j B 744-750 disorder
       Region 6v9j B 751-1046 order
 Evidence X-RAY 6v9l B Reference
       Region 6v9l B 566-590 order
       Region 6v9l B 591-596 disorder
       Region 6v9l B 597-743 order
       Region 6v9l B 744-750 disorder
       Region 6v9l B 751-1046 order
 Evidence X-RAY 6v9m B Reference
       Region 6v9m B 566-590 order
       Region 6v9m B 591-596 disorder
       Region 6v9m B 597-743 order
       Region 6v9m B 744-750 disorder
       Region 6v9m B 751-1046 order
 Evidence X-RAY 6v9n B Reference
       Region 6v9n B 566-590 order
       Region 6v9n B 591-596 disorder
       Region 6v9n B 597-743 order
       Region 6v9n B 744-750 disorder
       Region 6v9n B 751-1046 order
 Evidence X-RAY 6v9o B Reference
       Region 6v9o B 566-590 order
       Region 6v9o B 591-596 disorder
       Region 6v9o B 597-743 order
       Region 6v9o B 744-750 disorder
       Region 6v9o B 751-1046 order
 Evidence X-RAY 5wfo N Reference
       Region 5wfo N 566-590 order
       Region 5wfo N 591-596 disorder
       Region 5wfo N 597-743 order
       Region 5wfo N 744-750 disorder
       Region 5wfo N 751-1046 order
 Evidence X-RAY 5wfp N Reference
       Region 5wfp N 566-590 order
       Region 5wfp N 591-596 disorder
       Region 5wfp N 597-743 order
       Region 5wfp N 744-750 disorder
       Region 5wfp N 751-1046 order
 Evidence X-RAY 5wfq N Reference
       Region 5wfq N 566-593 order
       Region 5wfq N 594-596 disorder
       Region 5wfq N 597-743 order
       Region 5wfq N 744-750 disorder
       Region 5wfq N 751-1046 order
 Evidence X-RAY 5wfr N Reference
       Region 5wfr N 566-590 order
       Region 5wfr N 591-596 disorder
       Region 5wfr N 597-743 order
       Region 5wfr N 744-750 disorder
       Region 5wfr N 751-1046 order
Seq 568-1044 Hetero octamer : P01112
 Evidence X-RAY 1bkd S Reference
       Region 1bkd S 568-590 order
       Region 1bkd S 591-596 disorder
       Region 1bkd S 597-653 order
       Region 1bkd S 654-675 disorder
       Region 1bkd S 676-741 order
       Region 1bkd S 742-751 disorder
       Region 1bkd S 752-1044 order
Seq 1155-1167 Hetero dimer : IID00301Complex
 Evidence X-RAY 6y44 P Reference
       Region 6y44 P 1155-1157 disorder
       Region 6y44 P 1158-1166 order
       Region 6y44 P 1167-1167 disorder
Seq 1155-1167 Hetero tetramer : IID00061Complex
 Evidence X-RAY 6f08 D Reference
       Region 6f08 D 1155-1156 disorder
       Region 6f08 D 1157-1165 order
       Region 6f08 D 1166-1167 disorder
 Evidence X-RAY 6f08 Q Reference
       Region 6f08 Q 1155-1156 disorder
       Region 6f08 Q 1157-1166 order
       Region 6f08 Q 1167-1167 disorder
 Evidence X-RAY 6f08 K Reference
       Region 6f08 K 1155-1155 disorder
       Region 6f08 K 1156-1165 order
       Region 6f08 K 1166-1167 disorder
 Evidence X-RAY 6f08 N Reference
       Region 6f08 N 1155-1156 disorder
       Region 6f08 N 1157-1164 order
       Region 6f08 N 1165-1167 disorder
SeqProS predicted 1156-1166 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero tetramer : IID00061Complex
       Region 6f08 D 1157-1165 order
       Region 6f08 K 1156-1165 order
       Region 6f08 N 1157-1164 order
       Region 6f08 Q 1157-1166 order
SeqProS predicted 1156-1166 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00301Complex
       Region 6y44 P 1158-1166 order
Seqphosphorylation
    1078-1078 Phosphoserine
    1082-1082 Phosphoserine
    1134-1134 Phosphoserine; by RPS6KA3
    1161-1161 Phosphoserine; by RPS6KA3
    1178-1178 Phosphoserine
    1210-1210 Phosphoserine
    1229-1229 Phosphoserine
    1275-1275 Phosphoserine
 
Prediction
NeProc
Disorder 1-7,181-197,536-568,661-671,745-763,1025-1333
Order 8-180,198-409,415-476,486-535,569-660,672-744,771-1024
ProS 536-557,661-661,745-753,1025-1039,1117-1123,1223-1233,1300-1333
AlphaFold
Disorder 1-6,96-101,153-153,177-198,403-418,498-498,565-566,591-597,746-753,1045-1333
Order 7-95,102-152,154-176,199-402,419-497,499-564,567-590,598-745,754-1044
Pfam Hmmer
PF00125 97-169 1.7e-15
PF00621 204-389 9.8e-10
PF00169 444-546 1.3e-20
PF00618 600-717 1.3e-42
PF00617 777-963 2.5e-66
SEG 644-657 ,1079-1093 ,1103-1116 ,1146-1168 ,1207-1223 ,1227-1238 ,1248-1266
Function
Function in SwissProt
Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity).