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IID00825
 UniprotQ12852
ProteinMitogen-activated protein kinase kinase kinase 12
GeneMAP3K12
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
859
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 115-402 Monomer :
 Evidence X-RAY 5cen A Reference
       Region 5cen A 115-116 disorder
       Region 5cen A 117-397 order
       Region 5cen A 398-402 disorder
 Evidence X-RAY 5ceo A Reference
       Region 5ceo A 115-116 disorder
       Region 5ceo A 117-256 order
       Region 5ceo A 257-269 disorder
       Region 5ceo A 270-398 order
       Region 5ceo A 399-402 disorder
 Evidence X-RAY 5cep A Reference
       Region 5cep A 115-116 disorder
       Region 5cep A 117-256 order
       Region 5cep A 257-269 disorder
       Region 5cep A 270-398 order
       Region 5cep A 399-402 disorder
 Evidence X-RAY 5ceq A Reference
       Region 5ceq A 115-116 disorder
       Region 5ceq A 117-256 order
       Region 5ceq A 257-269 disorder
       Region 5ceq A 270-398 order
       Region 5ceq A 399-402 disorder
 Evidence X-RAY 5vo1 A Reference
       Region 5vo1 A 115-116 disorder
       Region 5vo1 A 117-256 order
       Region 5vo1 A 257-269 disorder
       Region 5vo1 A 270-398 order
       Region 5vo1 A 399-402 disorder
 Evidence X-RAY 5vo2 A Reference
       Region 5vo2 A 115-116 disorder
       Region 5vo2 A 117-256 order
       Region 5vo2 A 257-269 disorder
       Region 5vo2 A 270-398 order
       Region 5vo2 A 399-402 disorder
Seqphosphorylation
    695-695 Phosphoserine
    607-607 Phosphoserine
    43-43 Phosphothreonine
    37-37 Phosphothreonine
 
Prediction
NeProc
Disorder 1-62,468-859
Order 63-105,115-467
ProS 1-6,13-30,37-62,468-496,505-509,516-522,543-551,575-584,610-622,630-651,703-707,723-730,780-786,798-806,812-859
AlphaFold
Disorder 1-97,99-116,134-136,256-272,401-408,467-859
Order 98-98,117-133,137-255,273-400,409-466
Pfam Hmmer
PF00069 125-364 5e-71
SEG 55-71 ,404-420 ,446-467 ,526-544 ,567-584 ,607-640 ,658-695 ,718-731 ,802-815
Function
Function in SwissProt
Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway.