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IID00826
UniprotQ13216
ProteinDNA excision repair protein ERCC-8
GeneERCC8
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
396
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-396 Hetero dimer : IID00840Complex
 Evidence X-RAY 4a11 B Reference
       Region 4a11 B 1-365 order
       Region 4a11 B 366-396 disorder
 Evidence X-RAY 6fcv B Reference
       Region 6fcv B 1-365 order
       Region 6fcv B 366-396 disorder
Seqphosphorylation
    392-392 Phosphoserine
    391-391 Phosphoserine
    390-390 Phosphoserine
 
Prediction
NeProc
Disorder 390-396
Order 1-233,239-389
ProS 390-396
AlphaFold
Disorder 366-396
Order 1-365
Pfam Hmmer
PF00400 89-128 0.00063
PF00400 176-215 5.4e-11
PF00400 235-273 0.00012
PF00400 324-362 9.8e-05
Function
Function in SwissProt
Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. Plays a role in DNA single-strand and double-strand breaks (DSSBs) repair; involved in repair of DSSBs by non-homologous end joining (NHEJ) (PubMed:29545921).