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IID00827
 UniprotQ13283
ProteinRas GTPase-activating protein-binding protein 1
GeneG3BP1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
466
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-139 Hetero trimer : Q14694
 Evidence X-RAY 7xhf B Reference
       Region 7xhf B 1-5 disorder
       Region 7xhf B 6-139 order
 Evidence X-RAY 7xhf A Reference
       Region 7xhf A 1-5 disorder
       Region 7xhf A 6-42 order
       Region 7xhf A 43-51 disorder
       Region 7xhf A 52-138 order
       Region 7xhf A 139-139 disorder
Seq 1-139 Hetero heptamer : IID00668Complex
 Evidence X-RAY 7xhg D Reference
       Region 7xhg D 1-5 disorder
       Region 7xhg D 6-138 order
       Region 7xhg D 139-139 disorder
 Evidence X-RAY 7xhg C Reference
       Region 7xhg C 1-5 disorder
       Region 7xhg C 6-42 order
       Region 7xhg C 43-49 disorder
       Region 7xhg C 50-138 order
       Region 7xhg C 139-139 disorder
 Evidence X-RAY 7xhg B Reference
       Region 7xhg B 1-5 disorder
       Region 7xhg B 6-138 order
       Region 7xhg B 139-139 disorder
 Evidence X-RAY 7xhg A Reference
       Region 7xhg A 1-5 disorder
       Region 7xhg A 6-138 order
       Region 7xhg A 139-139 disorder
Seq 1-139 Homo dimer :
 Evidence X-RAY 4fcj A Reference
       Region 4fcj A 1-42 order
       Region 4fcj A 43-51 disorder
       Region 4fcj A 52-137 order
       Region 4fcj A 138-139 disorder
 Evidence X-RAY 4fcj B Reference
       Region 4fcj B 1-45 order
       Region 4fcj B 46-50 disorder
       Region 4fcj B 51-116 order
       Region 4fcj B 117-123 disorder
       Region 4fcj B 124-138 order
       Region 4fcj B 139-139 disorder
 Evidence X-RAY 4iia A Reference
       Region 4iia A 11-138 order
       Region 4iia A 139-139 disorder
 Evidence X-RAY 3q90 A Reference
       Region 3q90 A 1-6 disorder
       Region 3q90 A 7-41 order
       Region 3q90 A 42-51 disorder
       Region 3q90 A 52-137 order
       Region 3q90 A 138-139 disorder
 Evidence X-RAY 3q90 B Reference
       Region 3q90 B 1-46 order
       Region 3q90 B 47-50 disorder
       Region 3q90 B 51-117 order
       Region 3q90 B 118-123 disorder
       Region 3q90 B 124-139 order
 Evidence X-RAY 7s17 A Reference
       Region 7s17 A 1-138 order
 Evidence X-RAY 7s17 B Reference
       Region 7s17 B 1-47 order
       Region 7s17 B 48-50 disorder
       Region 7s17 B 51-116 order
       Region 7s17 B 117-123 disorder
       Region 7s17 B 124-138 order
Seq 1-139 Hetero hexamer : P08411
 Evidence X-RAY 5fw5 B Reference
       Region 5fw5 B 1-4 disorder
       Region 5fw5 B 5-135 order
       Region 5fw5 B 136-139 disorder
 Evidence X-RAY 5fw5 A Reference
       Region 5fw5 A 1-138 order
       Region 5fw5 A 139-139 disorder
Seq 1-139 Hetero tetramer :
 Evidence X-RAY 4fcm B Reference
       Region 4fcm B 1-46 order
       Region 4fcm B 47-49 disorder
       Region 4fcm B 50-138 order
       Region 4fcm B 139-139 disorder
 Evidence X-RAY 4fcm A Reference
       Region 4fcm A 1-6 disorder
       Region 4fcm A 7-138 order
       Region 4fcm A 139-139 disorder
Seq 1-139 Hetero heptamer : IID00668Complex
 Evidence X-RAY 6ta7 F Reference
       Region 6ta7 F 1-47 order
       Region 6ta7 F 48-50 disorder
       Region 6ta7 F 51-117 order
       Region 6ta7 F 118-119 disorder
       Region 6ta7 F 120-134 order
       Region 6ta7 F 135-139 disorder
 Evidence X-RAY 6ta7 E Reference
       Region 6ta7 E 1-2 disorder
       Region 6ta7 E 3-42 order
       Region 6ta7 E 43-51 disorder
       Region 6ta7 E 52-117 order
       Region 6ta7 E 118-119 disorder
       Region 6ta7 E 120-138 order
       Region 6ta7 E 139-139 disorder
 Evidence X-RAY 6ta7 D Reference
       Region 6ta7 D 1-3 disorder
       Region 6ta7 D 4-43 order
       Region 6ta7 D 44-51 disorder
       Region 6ta7 D 52-118 order
       Region 6ta7 D 119-120 disorder
       Region 6ta7 D 121-138 order
       Region 6ta7 D 139-139 disorder
 Evidence X-RAY 6ta7 C Reference
       Region 6ta7 C 1-3 disorder
       Region 6ta7 C 4-47 order
       Region 6ta7 C 48-49 disorder
       Region 6ta7 C 50-117 order
       Region 6ta7 C 118-123 disorder
       Region 6ta7 C 124-139 order
 Evidence X-RAY 6ta7 B Reference
       Region 6ta7 B 1-3 disorder
       Region 6ta7 B 4-117 order
       Region 6ta7 B 118-123 disorder
       Region 6ta7 B 124-138 order
       Region 6ta7 B 139-139 disorder
 Evidence X-RAY 6ta7 A Reference
       Region 6ta7 A 1-48 order
       Region 6ta7 A 49-49 disorder
       Region 6ta7 A 50-116 order
       Region 6ta7 A 117-123 disorder
       Region 6ta7 A 124-138 order
       Region 6ta7 A 139-139 disorder
Seq 2-139 Hetero tetramer : P0DTC9
 Evidence X-RAY 7suo B Reference
       Region 7suo B 2-138 order
       Region 7suo B 139-139 disorder
 Evidence X-RAY 7suo A Reference
       Region 7suo A 2-2 disorder
       Region 7suo A 3-138 order
       Region 7suo A 139-139 disorder
Seqphosphorylation
    143-143 Phosphothreonine
    149-149 Phosphoserine
    231-231 Phosphoserine
    232-232 Phosphoserine
    250-250 Phosphoserine
    253-253 Phosphoserine
    373-373 Phosphoserine
Seqacetylation
    376-376 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-4,138-335,414-466
Order 5-47,53-137,336-413
ProS 178-181,419-429,437-466
AlphaFold
Disorder 1-3,139-336,374-377,415-466
Order 4-138,337-373,378-414
Pfam Hmmer
PF02136 11-133 5.5e-45
PF00076 342-402 2e-13
SEG 142-167 ,184-213 ,291-307 ,421-450
Function
Function in SwissProt
Protein involved in various processes, such as stress granule formation and innate immunity (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:30510222, PubMed:30804210). Plays an essential role in stress granule formation (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:36183834, PubMed:36279435, PubMed:34739333, PubMed:36692217, PubMed:37379838). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:36279435, PubMed:37379838). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:36692217, PubMed:36279435). Also acts as an ATP- and magnesium-dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (PubMed:30510222, PubMed:30804210). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (PubMed:30510222). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles (PubMed:34779554). Enhances also RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (PubMed:30804210). May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510).