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IID00828
 UniprotQ13426
ProteinDNA repair protein XRCC4
GeneXRCC4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
336
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-140 Hetero octamer : IID00903Complex
 Evidence X-RAY 3sr2 F Reference
       Region 3sr2 F 1-140 order
 Evidence X-RAY 3sr2 E Reference
       Region 3sr2 E 1-140 order
 Evidence X-RAY 3sr2 B Reference
       Region 3sr2 B 1-140 order
 Evidence X-RAY 3sr2 A Reference
       Region 3sr2 A 1-139 order
       Region 3sr2 A 140-140 disorder
Seq 1-157
 Evidence X-RAY 3rwr V Reference
       Region 3rwr V 1-157 order
Seq 1-157
 Evidence X-RAY 3rwr N Reference
       Region 3rwr N 1-157 order
Seq 1-157
 Evidence X-RAY 3rwr P Reference
       Region 3rwr P 1-157 order
Seq 1-157 Hetero tetramer : IID00903Complex
 Evidence X-RAY 3q4f D Reference
       Region 3q4f D 1-157 order
 Evidence X-RAY 3q4f C Reference
       Region 3q4f C 1-157 order
 Evidence X-RAY 3q4f H Reference
       Region 3q4f H 1-157 order
 Evidence X-RAY 3q4f G Reference
       Region 3q4f G 1-157 order
Seq 1-157
 Evidence X-RAY 3rwr R Reference
       Region 3rwr R 1-157 order
Seq 1-157
 Evidence X-RAY 3rwr U Reference
       Region 3rwr U 1-157 order
Seq 1-157
 Evidence X-RAY 3rwr K Reference
       Region 3rwr K 1-157 order
Seq 1-157
 Evidence X-RAY 3rwr J Reference
       Region 3rwr J 1-157 order
Seq 1-157 Hetero octamer : IID00903Complex
 Evidence X-RAY 3rwr G Reference
       Region 3rwr G 1-157 order
 Evidence X-RAY 3rwr F Reference
       Region 3rwr F 1-157 order
 Evidence X-RAY 3rwr B Reference
       Region 3rwr B 1-76 order
       Region 3rwr B 77-81 disorder
       Region 3rwr B 82-157 order
 Evidence X-RAY 3rwr A Reference
       Region 3rwr A 1-147 order
       Region 3rwr A 148-157 disorder
Seq 1-157
 Evidence X-RAY 3rwr Y Reference
       Region 3rwr Y 1-157 order
Seq 1-164 Homo dimer :
 Evidence X-RAY 3w03 D Reference
       Region 3w03 D 1-164 order
 Evidence X-RAY 3w03 C Reference
       Region 3w03 C 1-164 order
Seq 1-203 Homo tetramer :
 Evidence X-RAY 1fu1 B Reference
       Region 1fu1 B 1-203 order
 Evidence X-RAY 1fu1 A Reference
       Region 1fu1 A 1-178 order
       Region 1fu1 A 179-203 disorder
Seq 1-203 Hetero trimer : P49917
 Evidence X-RAY 3ii6 A Reference
       Region 3ii6 A 1-201 order
       Region 3ii6 A 202-203 disorder
 Evidence X-RAY 3ii6 B Reference
       Region 3ii6 B 1-76 order
       Region 3ii6 B 77-81 disorder
       Region 3ii6 B 82-201 order
       Region 3ii6 B 202-203 disorder
 Evidence X-RAY 3ii6 C Reference
       Region 3ii6 C 1-201 order
       Region 3ii6 C 202-203 disorder
 Evidence X-RAY 3ii6 D Reference
       Region 3ii6 D 1-76 order
       Region 3ii6 D 77-82 disorder
       Region 3ii6 D 83-201 order
       Region 3ii6 D 202-203 disorder
Seq 1-213 Hetero trimer : P49917
 Evidence X-RAY 1ik9 B Reference
       Region 1ik9 B 1-76 order
       Region 1ik9 B 77-82 disorder
       Region 1ik9 B 83-201 order
       Region 1ik9 B 202-213 disorder
 Evidence X-RAY 1ik9 A Reference
       Region 1ik9 A 1-76 order
       Region 1ik9 A 77-80 disorder
       Region 1ik9 A 81-211 order
       Region 1ik9 A 212-213 disorder
Seq 1-213 Hetero dimer : Q0D2I5
 Evidence X-RAY 6abo A Reference
       Region 6abo A 1-213 order
Seq 2-132 Hetero octamer : P12883
 Evidence X-RAY 5wlz D Reference
       Region 5wlz D 2-79 order
       Region 5wlz D 80-80 disorder
       Region 5wlz D 81-132 order
 Evidence X-RAY 5wlz C Reference
       Region 5wlz C 2-132 order
 Evidence X-RAY 5wlz B Reference
       Region 5wlz B 2-77 order
       Region 5wlz B 78-79 disorder
       Region 5wlz B 80-132 order
 Evidence X-RAY 5wlz A Reference
       Region 5wlz A 2-78 order
       Region 5wlz A 79-79 disorder
       Region 5wlz A 80-132 order
Seq 2-132 Hetero tetramer : P12883
 Evidence X-RAY 5wj7 B Reference
       Region 5wj7 B 2-132 order
 Evidence X-RAY 5wj7 A Reference
       Region 5wj7 A 2-132 order
Seq 2-132 Hetero tetramer : P32380
 Evidence X-RAY 7m3p B Reference
       Region 7m3p B 2-2 disorder
       Region 7m3p B 3-24 order
       Region 7m3p B 25-26 disorder
       Region 7m3p B 27-76 order
       Region 7m3p B 77-82 disorder
       Region 7m3p B 83-132 order
 Evidence X-RAY 7m3p A Reference
       Region 7m3p A 2-76 order
       Region 7m3p A 77-82 disorder
       Region 7m3p A 83-132 order
Seq 2-133 Hetero heptamer : P04268,P09493,Q15691
 Evidence X-RAY 3mud B Reference
       Region 3mud B 2-133 order
 Evidence X-RAY 3mud A Reference
       Region 3mud A 2-133 order
Seq 2-142 Hetero tetramer : P12883
 Evidence X-RAY 5cj0 B Reference
       Region 5cj0 B 2-76 order
       Region 5cj0 B 77-78 disorder
       Region 5cj0 B 79-142 order
 Evidence X-RAY 5cj0 A Reference
       Region 5cj0 A 2-142 order
Seq 2-143 Hetero tetramer : P12883
 Evidence X-RAY 5chx B Reference
       Region 5chx B 2-79 order
       Region 5chx B 80-82 disorder
       Region 5chx B 83-143 order
 Evidence X-RAY 5chx A Reference
       Region 5chx A 2-79 order
       Region 5chx A 80-81 disorder
       Region 5chx A 82-143 order
Seq 2-144 Hetero tetramer : P12883
 Evidence X-RAY 5cj4 D Reference
       Region 5cj4 D 2-76 order
       Region 5cj4 D 77-82 disorder
       Region 5cj4 D 83-144 order
 Evidence X-RAY 5cj4 C Reference
       Region 5cj4 C 2-76 order
       Region 5cj4 C 77-81 disorder
       Region 5cj4 C 82-144 order
Seq 2-144 Hetero tetramer : P12883
 Evidence X-RAY 5cj4 B Reference
       Region 5cj4 B 2-79 order
       Region 5cj4 B 80-80 disorder
       Region 5cj4 B 81-144 order
 Evidence X-RAY 5cj4 A Reference
       Region 5cj4 A 2-77 order
       Region 5cj4 A 78-81 disorder
       Region 5cj4 A 82-144 order
Seq 2-147 Hetero tetramer : P12883
 Evidence X-RAY 4xa4 B Reference
       Region 4xa4 B 2-147 order
 Evidence X-RAY 4xa4 A Reference
       Region 4xa4 A 2-147 order
Seq 229-236 Hetero tetramer : IID00848Complex
 Evidence X-RAY 5e50 D Reference
       Region 5e50 D 229-235 order
       Region 5e50 D 236-236 disorder
 Evidence X-RAY 5e50 C Reference
       Region 5e50 C 229-235 order
       Region 5e50 C 236-236 disorder
SeqProS predicted 229-235 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero tetramer : IID00848Complex
       Region 5e50 C 229-235 order
       Region 5e50 D 229-235 order
Seqphosphorylation
    53-53 Phosphoserine; by PRKDC
    193-193 Phosphoserine; by PRKDC
    229-229 Phosphotyrosine
    232-232 Phosphoserine
    233-233 Phosphothreonine; by CK2
    237-237 Phosphoserine
    256-256 Phosphoserine
    260-260 Phosphoserine; by PRKDC
    303-303 Phosphoserine; by PRKDC
    304-304 Phosphoserine; by PRKDC
    315-315 Phosphoserine; by PRKDC
    320-320 Phosphoserine; by PRKDC
    323-323 Phosphothreonine; by PRKDC
    327-327 Phosphoserine; by PRKDC
    328-328 Phosphoserine; by PRKDC
 
Prediction
NeProc
Disorder 212-336
Order 1-211
ProS 261-267,329-336
AlphaFold
Disorder 206-336
Order 1-205
Pfam Hmmer
PF06632 1-334 3.4e-281
Function
Function in SwissProt
Acts as an activator of the phospholipid scramblase activity of XKR4 (PubMed:33725486). This form, which is generated upon caspase-3 (CASP3) cleavage, translocates into the cytoplasm and interacts with XKR4, thereby promoting phosphatidylserine scramblase activity of XKR4 and leading to phosphatidylserine exposure on apoptotic cell surface (PubMed:33725486).
Biological Process
See also
Diagram with PDB data
XRCC6/XRCC5/NHEJ1Complex of XLF and heterodimer Ku bound to DNA