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IID00829
 UniprotQ13526
ProteinPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1
GenePIN1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
163
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-44 Monomer :
 Evidence NMR 1i6c A Reference
       Region 1i6c A 6-44 order
       Region 1i6c A 42-44 high_rmsd
 Evidence NMR 2kbu A Reference
       Region 2kbu A 6-15 order
       Region 2kbu A 6-8 high_rmsd
       Region 2kbu A 19-19 order
       Region 2kbu A 20-20 disorder
       Region 2kbu A 21-39 order
       Region 2kbu A 35-36 high_rmsd
 Evidence NMR 2kcf A Reference
       Region 2kcf A 6-39 order
 Evidence NMR 2m8i A Reference
       Region 2m8i A 1-39 order
 Evidence NMR 2m8j A Reference
       Region 2m8j A 1-39 order
 Evidence NMR 2m9i A Reference
       Region 2m9i A 6-39 order
       Region 2m9i A 6-7 high_rmsd
       Region 2m9i A 39-39 high_rmsd
 Evidence NMR 2m9j A Reference
       Region 2m9j A 6-39 order
       Region 2m9j A 6-6 high_rmsd
 Evidence X-RAY 4gwt A Reference
       Region 4gwt A 6-38 order
       Region 4gwt A 39-39 disorder
 Evidence X-RAY 4gwv A Reference
       Region 4gwv A 6-38 order
       Region 4gwv A 39-39 disorder
 Evidence X-RAY 5vti A Reference
       Region 5vti A 6-15 order
       Region 5vti A 18-18 order
       Region 5vti A 19-19 disorder
       Region 5vti A 20-38 order
       Region 5vti A 39-39 disorder
 Evidence X-RAY 5vtj A Reference
       Region 5vtj A 6-17 order
       Region 5vtj A 18-18 disorder
       Region 5vtj A 19-38 order
       Region 5vtj A 39-39 disorder
 Evidence X-RAY 5vtk A Reference
       Region 5vtk A 6-38 order
       Region 5vtk A 39-39 disorder
 Evidence NMR 6svc A Reference
       Region 6svc A 6-39 order
 Evidence NMR 6sve A Reference
       Region 6sve A 6-39 order
 Evidence NMR 6svh A Reference
       Region 6svh A 6-39 order
Seq 1-163 Monomer :
 Evidence X-RAY 1f8a B Reference
       Region 1f8a B 1-38 order
       Region 1f8a B 39-50 disorder
       Region 1f8a B 51-163 order
 Evidence NMR 1nmv A Reference
       Region 1nmv A 1-163 order
       Region 1nmv A 1-49 high_rmsd
 Evidence NMR 1nmw A Reference
       Region 1nmw A 50-163 order
       Region 1nmw A 50-50 high_rmsd
 Evidence X-RAY 1zcn A Reference
       Region 1zcn A 1-6 disorder
       Region 1zcn A 7-15 order
       Region 1zcn A 18-38 order
       Region 1zcn A 39-50 disorder
       Region 1zcn A 51-161 order
 Evidence X-RAY 2f21 A Reference
       Region 2f21 A 1-16 order
       Region 2f21 A 18-39 order
       Region 2f21 A 40-48 disorder
       Region 2f21 A 49-162 order
 Evidence X-RAY 2itk A Reference
       Region 2itk A 1-6 disorder
       Region 2itk A 7-38 order
       Region 2itk A 39-50 disorder
       Region 2itk A 51-163 order
 Evidence X-RAY 2q5a A Reference
       Region 2q5a A 1-6 disorder
       Region 2q5a A 7-38 order
       Region 2q5a A 39-50 disorder
       Region 2q5a A 51-163 order
 Evidence NMR 2ruc A Reference
       Region 2ruc A 51-163 order
 Evidence NMR 2rud A Reference
       Region 2rud A 51-163 order
 Evidence NMR 2ruq A Reference
       Region 2ruq A 51-163 order
 Evidence NMR 2rur A Reference
       Region 2rur A 51-163 order
 Evidence X-RAY 2xp3 A Reference
       Region 2xp3 A 1-6 disorder
       Region 2xp3 A 7-38 order
       Region 2xp3 A 39-50 disorder
       Region 2xp3 A 51-163 order
 Evidence X-RAY 2xp4 A Reference
       Region 2xp4 A 1-6 disorder
       Region 2xp4 A 7-37 order
       Region 2xp4 A 38-50 disorder
       Region 2xp4 A 51-163 order
 Evidence X-RAY 2xp5 A Reference
       Region 2xp5 A 1-6 disorder
       Region 2xp5 A 7-38 order
       Region 2xp5 A 39-50 disorder
       Region 2xp5 A 51-163 order
 Evidence X-RAY 2xp6 A Reference
       Region 2xp6 A 1-6 disorder
       Region 2xp6 A 7-38 order
       Region 2xp6 A 39-50 disorder
       Region 2xp6 A 51-163 order
 Evidence X-RAY 2xp7 A Reference
       Region 2xp7 A 1-6 disorder
       Region 2xp7 A 7-38 order
       Region 2xp7 A 39-50 disorder
       Region 2xp7 A 51-163 order
 Evidence X-RAY 2xp8 A Reference
       Region 2xp8 A 1-6 disorder
       Region 2xp8 A 7-38 order
       Region 2xp8 A 39-50 disorder
       Region 2xp8 A 51-163 order
 Evidence X-RAY 2xp9 A Reference
       Region 2xp9 A 1-6 disorder
       Region 2xp9 A 7-37 order
       Region 2xp9 A 38-50 disorder
       Region 2xp9 A 51-163 order
 Evidence X-RAY 2xpa A Reference
       Region 2xpa A 1-6 disorder
       Region 2xpa A 7-39 order
       Region 2xpa A 40-50 disorder
       Region 2xpa A 51-163 order
 Evidence X-RAY 2xpb A Reference
       Region 2xpb A 1-6 disorder
       Region 2xpb A 7-39 order
       Region 2xpb A 40-50 disorder
       Region 2xpb A 51-163 order
 Evidence X-RAY 2zqs A Reference
       Region 2zqs A 1-5 disorder
       Region 2zqs A 6-39 order
       Region 2zqs A 40-44 disorder
       Region 2zqs A 45-163 order
 Evidence X-RAY 2zqt A Reference
       Region 2zqt A 1-5 disorder
       Region 2zqt A 6-39 order
       Region 2zqt A 40-44 disorder
       Region 2zqt A 45-163 order
 Evidence X-RAY 2zqu A Reference
       Region 2zqu A 1-5 disorder
       Region 2zqu A 6-39 order
       Region 2zqu A 40-44 disorder
       Region 2zqu A 45-163 order
 Evidence X-RAY 2zqv A Reference
       Region 2zqv A 1-5 disorder
       Region 2zqv A 6-39 order
       Region 2zqv A 40-44 disorder
       Region 2zqv A 45-163 order
 Evidence X-RAY 2zr4 A Reference
       Region 2zr4 A 1-5 disorder
       Region 2zr4 A 6-39 order
       Region 2zr4 A 40-44 disorder
       Region 2zr4 A 45-163 order
 Evidence X-RAY 2zr5 A Reference
       Region 2zr5 A 1-5 disorder
       Region 2zr5 A 6-39 order
       Region 2zr5 A 40-44 disorder
       Region 2zr5 A 45-163 order
 Evidence X-RAY 2zr6 A Reference
       Region 2zr6 A 1-5 disorder
       Region 2zr6 A 6-39 order
       Region 2zr6 A 40-44 disorder
       Region 2zr6 A 45-163 order
 Evidence X-RAY 3i6c A Reference
       Region 3i6c A 45-50 disorder
       Region 3i6c A 51-163 order
 Evidence X-RAY 3i6c B Reference
       Region 3i6c B 45-50 disorder
       Region 3i6c B 51-163 order
 Evidence X-RAY 3ik8 A Reference
       Region 3ik8 A 45-50 disorder
       Region 3ik8 A 51-163 order
 Evidence X-RAY 3ik8 B Reference
       Region 3ik8 B 45-53 disorder
       Region 3ik8 B 54-163 order
 Evidence X-RAY 3ikd A Reference
       Region 3ikd A 45-50 disorder
       Region 3ikd A 51-163 order
 Evidence X-RAY 3ikd B Reference
       Region 3ikd B 45-53 disorder
       Region 3ikd B 54-163 order
 Evidence X-RAY 3ikg A Reference
       Region 3ikg A 45-50 disorder
       Region 3ikg A 51-163 order
 Evidence X-RAY 3ikg B Reference
       Region 3ikg B 45-50 disorder
       Region 3ikg B 51-163 order
 Evidence X-RAY 3jyj A Reference
       Region 3jyj A 45-50 disorder
       Region 3jyj A 51-163 order
 Evidence X-RAY 3jyj B Reference
       Region 3jyj B 45-50 disorder
       Region 3jyj B 51-163 order
 Evidence X-RAY 3kab A Reference
       Region 3kab A 1-6 disorder
       Region 3kab A 7-38 order
       Region 3kab A 39-50 disorder
       Region 3kab A 51-163 order
 Evidence X-RAY 3kac A Reference
       Region 3kac A 45-50 disorder
       Region 3kac A 51-163 order
 Evidence X-RAY 3kac B Reference
       Region 3kac B 45-48 disorder
       Region 3kac B 49-163 order
 Evidence X-RAY 3kad A Reference
       Region 3kad A 1-6 disorder
       Region 3kad A 7-38 order
       Region 3kad A 39-50 disorder
       Region 3kad A 51-163 order
 Evidence X-RAY 3kaf A Reference
       Region 3kaf A 1-6 disorder
       Region 3kaf A 7-38 order
       Region 3kaf A 39-50 disorder
       Region 3kaf A 51-163 order
 Evidence X-RAY 3kag A Reference
       Region 3kag A 1-6 disorder
       Region 3kag A 7-38 order
       Region 3kag A 39-50 disorder
       Region 3kag A 51-163 order
 Evidence X-RAY 3kah A Reference
       Region 3kah A 1-6 disorder
       Region 3kah A 7-38 order
       Region 3kah A 39-50 disorder
       Region 3kah A 51-163 order
 Evidence X-RAY 3kai A Reference
       Region 3kai A 1-6 disorder
       Region 3kai A 7-38 order
       Region 3kai A 39-50 disorder
       Region 3kai A 51-163 order
 Evidence X-RAY 3kce A Reference
       Region 3kce A 1-5 disorder
       Region 3kce A 6-38 order
       Region 3kce A 39-50 disorder
       Region 3kce A 51-163 order
 Evidence X-RAY 3ntp A Reference
       Region 3ntp A 1-5 disorder
       Region 3ntp A 6-38 order
       Region 3ntp A 39-49 disorder
       Region 3ntp A 50-163 order
 Evidence X-RAY 3odk A Reference
       Region 3odk A 1-6 disorder
       Region 3odk A 7-38 order
       Region 3odk A 39-50 disorder
       Region 3odk A 51-163 order
 Evidence X-RAY 3oob A Reference
       Region 3oob A 1-5 disorder
       Region 3oob A 6-38 order
       Region 3oob A 39-50 disorder
       Region 3oob A 51-163 order
 Evidence X-RAY 3tc5 A Reference
       Region 3tc5 A 1-6 disorder
       Region 3tc5 A 7-37 order
       Region 3tc5 A 38-50 disorder
       Region 3tc5 A 51-163 order
 Evidence X-RAY 3tcz A Reference
       Region 3tcz A 6-38 order
       Region 3tcz A 39-50 disorder
       Region 3tcz A 51-163 order
 Evidence X-RAY 3tdb A Reference
       Region 3tdb A 6-38 order
       Region 3tdb A 39-50 disorder
       Region 3tdb A 51-163 order
 Evidence X-RAY 3wh0 A Reference
       Region 3wh0 A 1-6 disorder
       Region 3wh0 A 7-38 order
       Region 3wh0 A 39-50 disorder
       Region 3wh0 A 51-163 order
 Evidence X-RAY 4qib A Reference
       Region 4qib A 7-38 order
       Region 4qib A 39-50 disorder
       Region 4qib A 51-163 order
 Evidence X-RAY 4tns A Reference
       Region 4tns A 43-50 disorder
       Region 4tns A 51-163 order
 Evidence X-RAY 4tns B Reference
       Region 4tns B 43-49 disorder
       Region 4tns B 50-163 order
 Evidence X-RAY 4tyo A Reference
       Region 4tyo A 45-50 disorder
       Region 4tyo A 51-163 order
 Evidence X-RAY 4tyo B Reference
       Region 4tyo B 45-48 disorder
       Region 4tyo B 49-163 order
 Evidence X-RAY 4u84 A Reference
       Region 4u84 A 1-6 disorder
       Region 4u84 A 7-38 order
       Region 4u84 A 39-50 disorder
       Region 4u84 A 51-163 order
 Evidence X-RAY 4u85 A Reference
       Region 4u85 A 1-6 disorder
       Region 4u85 A 7-38 order
       Region 4u85 A 39-50 disorder
       Region 4u85 A 51-163 order
 Evidence X-RAY 4u86 A Reference
       Region 4u86 A 1-5 disorder
       Region 4u86 A 6-37 order
       Region 4u86 A 38-50 disorder
       Region 4u86 A 51-163 order
 Evidence NMR 5gph A Reference
       Region 5gph A 51-163 order
 Evidence X-RAY 5uy9 A Reference
       Region 5uy9 A 1-5 disorder
       Region 5uy9 A 6-38 order
       Region 5uy9 A 39-50 disorder
       Region 5uy9 A 51-163 order
 Evidence X-RAY 6o33 A Reference
       Region 6o33 A 1-5 disorder
       Region 6o33 A 6-39 order
       Region 6o33 A 40-47 disorder
       Region 6o33 A 48-163 order
 Evidence X-RAY 6o34 A Reference
       Region 6o34 A 1-5 disorder
       Region 6o34 A 6-39 order
       Region 6o34 A 40-47 disorder
       Region 6o34 A 48-163 order
 Evidence X-RAY 6vaj A Reference
       Region 6vaj A 1-5 disorder
       Region 6vaj A 6-39 order
       Region 6vaj A 40-47 disorder
       Region 6vaj A 48-163 order
 Evidence X-RAY 7efj A Reference
       Region 7efj A 1-5 disorder
       Region 7efj A 6-38 order
       Region 7efj A 39-49 disorder
       Region 7efj A 50-163 order
 Evidence X-RAY 7efx A Reference
       Region 7efx A 1-5 disorder
       Region 7efx A 6-38 order
       Region 7efx A 39-49 disorder
       Region 7efx A 50-163 order
 Evidence X-RAY 7ekv A Reference
       Region 7ekv A 1-5 disorder
       Region 7ekv A 6-38 order
       Region 7ekv A 39-50 disorder
       Region 7ekv A 51-163 order
 Evidence NMR 7sa5 A Reference
       Region 7sa5 A 1-163 order
       Region 7sa5 A 1-50 high_rmsd
 Evidence NMR 7suq A Reference
       Region 7suq A 1-163 order
       Region 7suq A 1-50 high_rmsd
 Evidence NMR 7sur A Reference
       Region 7sur A 1-163 order
       Region 7sur A 1-49 high_rmsd
Seq 1-163 Homo tetramer :
 Evidence X-RAY 7f0m A Reference
       Region 7f0m A 1-5 disorder
       Region 7f0m A 6-38 order
       Region 7f0m A 39-50 disorder
       Region 7f0m A 51-163 order
 Evidence X-RAY 7f0m B Reference
       Region 7f0m B 1-5 disorder
       Region 7f0m B 6-38 order
       Region 7f0m B 39-50 disorder
       Region 7f0m B 51-163 order
 Evidence X-RAY 7f0m C Reference
       Region 7f0m C 1-5 disorder
       Region 7f0m C 6-38 order
       Region 7f0m C 39-50 disorder
       Region 7f0m C 51-163 order
 Evidence X-RAY 7f0m D Reference
       Region 7f0m D 1-5 disorder
       Region 7f0m D 6-38 order
       Region 7f0m D 39-50 disorder
       Region 7f0m D 51-163 order
Seq 1-163 Homo dimer :
 Evidence X-RAY 1pin A Reference
       Region 1pin A 1-5 disorder
       Region 1pin A 6-39 order
       Region 1pin A 40-44 disorder
       Region 1pin A 45-163 order
 Evidence X-RAY 6dun A Reference
       Region 6dun A 46-48 disorder
       Region 6dun A 49-163 order
 Evidence X-RAY 6dun B Reference
       Region 6dun B 46-49 disorder
       Region 6dun B 50-163 order
Seq 5-15 Hetero dimer : IID90020Complex
 Evidence X-RAY 5b3x A Reference
       Region 5b3x A 5-6 disorder
       Region 5b3x A 7-15 order
Seq 5-15 Hetero tetramer : IID90020Complex
 Evidence X-RAY 5b3w A Reference
       Region 5b3w A 5-15 order
 Evidence X-RAY 5b3w B Reference
       Region 5b3w B 5-15 order
Seq 5-23 Hetero dimer : IID90020Complex
 Evidence X-RAY 5b3y A Reference
       Region 5b3y A 5-10 disorder
       Region 5b3y A 11-23 order
Seq 5-29 Hetero dimer : IID90020Complex
 Evidence X-RAY 5bmy A Reference
       Region 5bmy A 5-29 order
Seq 5-39 Hetero octamer : IID90020Complex
 Evidence X-RAY 5b3z A Reference
       Region 5b3z A 5-39 order
 Evidence X-RAY 5b3z B Reference
       Region 5b3z B 5-5 disorder
       Region 5b3z B 6-39 order
 Evidence X-RAY 5b3z C Reference
       Region 5b3z C 5-39 order
 Evidence X-RAY 5b3z D Reference
       Region 5b3z D 5-5 disorder
       Region 5b3z D 6-39 order
Seq 6-15,22-39 Hetero dimer :
 Evidence NMR 2m9e A Reference
       Region 2m9e A 6-15 order
       Region 2m9e A 6-6 high_rmsd
       Region 2m9e A 22-39 order
       Region 2m9e A 39-39 high_rmsd
Seq 6-15,22-39 Hetero dimer :
 Evidence NMR 2m9f A Reference
       Region 2m9f A 6-15 order
       Region 2m9f A 6-6 high_rmsd
       Region 2m9f A 22-39 order
       Region 2m9f A 39-39 high_rmsd
Seq 6-41 Hetero dimer : IID00127Complex
 Evidence NMR 2lb3 A Reference
       Region 2lb3 A 6-41 order
       Region 2lb3 A 40-41 high_rmsd
Seq 6-44 Hetero dimer : P30311
 Evidence NMR 1i8g B Reference
       Region 1i8g B 6-44 order
       Region 1i8g B 41-44 high_rmsd
Seq 6-44 Hetero dimer : IID00777Complex
 Evidence NMR 1i8h B Reference
       Region 1i8h B 6-44 order
       Region 1i8h B 39-44 high_rmsd
Seq 7-39 Hetero dimer : Q9BZB8
 Evidence NMR 2n1o A Reference
       Region 2n1o A 7-39 order
Seq 61-77 Hetero dimer : IID00301Complex
 Evidence X-RAY 7aog P Reference
       Region 7aog P 61-67 disorder
       Region 7aog P 68-76 order
       Region 7aog P 77-77 disorder
 Evidence X-RAY 7axn P Reference
       Region 7axn P 61-67 disorder
       Region 7axn P 68-76 order
       Region 7axn P 77-77 disorder
 Evidence X-RAY 7ayf P Reference
       Region 7ayf P 61-68 disorder
       Region 7ayf P 69-75 order
       Region 7ayf P 76-77 disorder
 Evidence X-RAY 7az1 P Reference
       Region 7az1 P 61-68 disorder
       Region 7az1 P 69-75 order
       Region 7az1 P 76-77 disorder
 Evidence X-RAY 7az2 P Reference
       Region 7az2 P 61-68 disorder
       Region 7az2 P 69-75 order
       Region 7az2 P 76-77 disorder
 Evidence X-RAY 7bdp P Reference
       Region 7bdp P 61-68 disorder
       Region 7bdp P 69-75 order
       Region 7bdp P 76-77 disorder
 Evidence X-RAY 7bdt P Reference
       Region 7bdt P 61-68 disorder
       Region 7bdt P 69-75 order
       Region 7bdt P 76-77 disorder
 Evidence X-RAY 7bdy P Reference
       Region 7bdy P 61-67 disorder
       Region 7bdy P 68-75 order
       Region 7bdy P 76-77 disorder
 Evidence X-RAY 7bfw P Reference
       Region 7bfw P 61-67 disorder
       Region 7bfw P 68-75 order
       Region 7bfw P 76-77 disorder
 Evidence X-RAY 7bg3 P Reference
       Region 7bg3 P 61-67 disorder
       Region 7bg3 P 68-75 order
       Region 7bg3 P 76-77 disorder
 Evidence X-RAY 7bgq P Reference
       Region 7bgq P 61-68 disorder
       Region 7bgq P 69-75 order
       Region 7bgq P 76-77 disorder
 Evidence X-RAY 7bgr P Reference
       Region 7bgr P 61-68 disorder
       Region 7bgr P 69-75 order
       Region 7bgr P 76-77 disorder
 Evidence X-RAY 7bgv P Reference
       Region 7bgv P 61-68 disorder
       Region 7bgv P 69-77 order
 Evidence X-RAY 7bgw P Reference
       Region 7bgw P 61-68 disorder
       Region 7bgw P 69-75 order
       Region 7bgw P 76-77 disorder
 Evidence X-RAY 7nif P Reference
       Region 7nif P 61-68 disorder
       Region 7nif P 69-75 order
       Region 7nif P 76-77 disorder
 Evidence X-RAY 7nig P Reference
       Region 7nig P 61-68 disorder
       Region 7nig P 69-75 order
       Region 7nig P 76-77 disorder
 Evidence X-RAY 7nj6 P Reference
       Region 7nj6 P 61-68 disorder
       Region 7nj6 P 69-74 order
       Region 7nj6 P 75-77 disorder
 Evidence X-RAY 7nj8 P Reference
       Region 7nj8 P 61-68 disorder
       Region 7nj8 P 69-75 order
       Region 7nj8 P 76-77 disorder
 Evidence X-RAY 7nja P Reference
       Region 7nja P 61-68 disorder
       Region 7nja P 69-74 order
       Region 7nja P 75-77 disorder
 Evidence X-RAY 7nrk P Reference
       Region 7nrk P 61-68 disorder
       Region 7nrk P 69-74 order
       Region 7nrk P 75-77 disorder
 Evidence X-RAY 7nrl P Reference
       Region 7nrl P 61-68 disorder
       Region 7nrl P 69-75 order
       Region 7nrl P 76-77 disorder
 Evidence X-RAY 7oq9 P Reference
       Region 7oq9 P 61-68 disorder
       Region 7oq9 P 69-74 order
       Region 7oq9 P 75-77 disorder
 Evidence X-RAY 7oqa P Reference
       Region 7oqa P 61-68 disorder
       Region 7oqa P 69-74 order
       Region 7oqa P 75-77 disorder
 Evidence X-RAY 8c2g P Reference
       Region 8c2g P 61-68 disorder
       Region 8c2g P 69-74 order
       Region 8c2g P 75-77 disorder
 Evidence X-RAY 8c3c B Reference
       Region 8c3c B 61-69 disorder
       Region 8c3c B 70-73 order
       Region 8c3c B 74-77 disorder
Seqphosphorylation
    108-108 Phosphoserine
    71-71 Phosphoserine; by DAPK1
    43-43 Phosphoserine
Seqacetylation
    46-46 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-4,34-48
Order 5-33,49-163
ProS 34-48
AlphaFold
Disorder 1-4,39-49
Order 5-38,50-163
Pfam Hmmer
PF00397 7-37 6.5e-16
PF00639 59-163 1.3e-41
SEG 38-48
Function
Function in SwissProt
Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383).
Biological Process
See also
Diagram with PDB data
SMAD3/NEDD4LStructure of the second domain of human Nedd4L in complex with a phosphorylated pTPY motif derived from human Smad3