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IID00830
UniprotQ13888
ProteinGeneral transcription factor IIH subunit 2
GeneGTF2H2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
395
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-395 Hetero tetramer : IID00831Complex
 Evidence X-RAY 5o85 D In 28977422, 5o85B and D are 321-395. Reference
       Region 5o85 D 1-325 disorder
       Region 5o85 D 326-338 order
       Region 5o85 D 339-342 disorder
       Region 5o85 D 343-351 order
       Region 5o85 D 352-356 disorder
       Region 5o85 D 357-387 order
       Region 5o85 D 388-395 disorder
 Evidence X-RAY 5o85 B In 28977422, 5o85B and D are 321-395. Reference
       Region 5o85 B 1-327 disorder
       Region 5o85 B 328-338 order
       Region 5o85 B 339-342 disorder
       Region 5o85 B 343-351 order
       Region 5o85 B 352-358 disorder
       Region 5o85 B 359-387 order
       Region 5o85 B 388-395 disorder
Seq 328-386 Monomer :
 Evidence NMR 1z60 A Reference
       Region 1z60 A 328-386 order
Seqphosphorylation
    95-95 Phosphotyrosine
 
Prediction
NeProc
Disorder 1-5,241-247,262-270,277-282,392-395
Order 6-240,248-261,271-276,283-391
ProS 262-270,392-395
AlphaFold
Disorder 1-26,28-28,30-35,41-41,45-51,261-267,274-283,389-395
Order 27-27,29-29,36-40,42-44,52-260,268-273,284-388
Pfam Hmmer
PF04056 7-255 4.2e-189
PF07975 344-387 8.2e-24
SEG 237-245 ,366-375
Function
Function in SwissProt
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter.
Biological Process
See also
Diagram with PDB data
XPA/ERCC1Solution structure of a ERCC1-XPA heterodimer
XPC/GTF2H1Solution structure of the complex between XPC acidic domain and TFIIH p62 PH domain