Search Keyword:


Search option:


IID00831
UniprotQ13889
ProteinGeneral transcription factor IIH subunit 3
GeneGTF2H3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
308
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-308 Hetero tetramer : IID00830Complex
 Evidence X-RAY 5o85 C In 28977422, 5o85A and C are 1-233. Reference
       Region 5o85 C 1-5 disorder
       Region 5o85 C 6-75 order
       Region 5o85 C 76-99 disorder
       Region 5o85 C 100-124 order
       Region 5o85 C 125-128 disorder
       Region 5o85 C 129-169 order
       Region 5o85 C 170-171 disorder
       Region 5o85 C 172-233 order
       Region 5o85 C 234-308 disorder
 Evidence X-RAY 5o85 A In 28977422, 5o85A and C are 1-233. Reference
       Region 5o85 A 1-7 disorder
       Region 5o85 A 8-72 order
       Region 5o85 A 73-104 disorder
       Region 5o85 A 105-151 order
       Region 5o85 A 152-155 disorder
       Region 5o85 A 156-233 order
       Region 5o85 A 234-308 disorder
 
Prediction
NeProc
Disorder 1-6,80-95,126-133,293-308
Order 7-25,31-79,96-125,134-292
AlphaFold
Disorder 1-5,74-101,122-128,292-308
Order 6-73,102-121,129-291
Pfam Hmmer
PF03850 7-286 4.5e-189
SEG 292-308
Function
Function in SwissProt
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Biological Process
See also
Diagram with PDB data
XPA/ERCC1Solution structure of a ERCC1-XPA heterodimer
XPC/GTF2H1Solution structure of the complex between XPC acidic domain and TFIIH p62 PH domain