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IID00832
 UniprotQ14188
ProteinTranscription factor Dp-2
GeneTFDP2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
446
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 121-215 Hetero dimer : IID00839Complex
 Evidence X-RAY 1cf7 B Reference
       Region 1cf7 B 121-128 disorder
       Region 1cf7 B 129-210 order
       Region 1cf7 B 211-215 disorder
Seqphosphorylation
    122-122 Phosphoserine
    24-24 Phosphoserine
Seqacetylation
    2-2 N-acetylthreonine
 
Prediction
NeProc
Disorder 10-17,23-127,362-446
Order 1-9,18-22,128-264,269-361
ProS 10-17,30-37,88-92,98-119,390-395,417-433
AlphaFold
Disorder 1-63,65-128,166-171,210-212,355-446
Order 64-64,129-165,172-209,213-354
Pfam Hmmer
PF02319 127-208 1.4e-43
SEG 196-207 ,221-245 ,253-263 ,409-422 ,432-444
Function
Function in SwissProt
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).
Biological Process
See also
Diagram with PDB data
LT_SV40/RB1RETINOBLASTOMA POCKET COMPLEXED WITH SV40 LARGE T ANTIGEN
E7/RB1RB POCKET BOUND TO E7 LXCXE MOTIF
E7/RBL1p107 pocket domain in complex with HPV E7 peptide
E1A_ADE05/RB1Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain
RB1/E2F1/TFDP1Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
RB1/PPP1CACrystal structure of an Rb C-terminal peptide bound to the catalytic subunit of PP1
RBL1/E2F5/TFDP1Crystal structure of the E2F5-DP1-p107 ternary complex
HDAC1/RBL1p107 pocket domain complexed with HDAC1 peptide