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IID00839
 UniprotQ16254
ProteinTranscription factor E2F4
GeneE2F4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
413
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 11-86 Hetero dimer : IID00832Complex
 Evidence X-RAY 1cf7 A Reference
       Region 1cf7 A 11-15 disorder
       Region 1cf7 A 16-82 order
       Region 1cf7 A 83-86 disorder
Seq 91-198 Hetero dimer : IID00076Complex
 Evidence X-RAY 5tuu B Reference
       Region 5tuu B 91-196 order
       Region 5tuu B 197-198 disorder
Seqphosphorylation
    384-384 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-16,201-370
Order 17-200,371-413
ProS 240-246,253-256,277-305,311-315,328-344,351-370
AlphaFold
Disorder 1-7,10-16,52-53,83-91,173-173,197-363,371-384,392-395,407-413
Order 8-9,17-51,54-82,92-172,174-196,364-370,385-391,396-406
Pfam Hmmer
PF02319 17-83 4.5e-38
SEG 4-15 ,96-116 ,203-212 ,307-327 ,363-375
Function
Function in SwissProt
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.
Biological Process
See also
Diagram with PDB data
E7/RBL1p107 pocket domain in complex with HPV E7 peptide
RBL1/E2F5/TFDP1Crystal structure of the E2F5-DP1-p107 ternary complex
HDAC1/RBL1p107 pocket domain complexed with HDAC1 peptide