Search Keyword:


Search option:


IID00841
 UniprotQ2YD98
ProteinUV-stimulated scaffold protein A
GeneUVSSA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
709
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 390-434
 Evidence NMR Reference
       Region 390-434 disorder
Seq 390-434 Hetero dimer : IID00549Complex
 Evidence NMR 5xv8 A Reference
       Region 5xv8 A 390-434 order
       Region 5xv8 A 390-399 high_rmsd
       Region 5xv8 A 420-434 high_rmsd
SeqProS verified 390-434 Hetero dimer : IID00549Complex
       Region 5xv8 A 390-434 order
       Region 390-434 disorder
Seqphosphorylation
    287-287 Phosphoserine
    281-281 Phosphoserine
 
Prediction
NeProc
Disorder 156-162,212-289,388-494,595-668
Order 1-155,163-211,290-387,495-514,520-594,669-709
ProS 156-162,244-266,275-289,388-392,404-428,453-471,595-604,616-639,653-668
AlphaFold
Disorder 1-1,141-156,206-289,310-313,384-423,425-425,427-455,457-458,460-460,463-464,466-484,515-515,517-519,521-521,523-526,528-529,531-541,617-619,621-621,642-653,700-709
Order 2-140,157-205,290-309,314-383,424-424,426-426,456-456,459-459,461-462,465-465,485-514,516-516,520-520,522-522,527-527,530-530,542-616,620-620,622-641,654-699
SEG 103-116 ,281-291 ,398-415 ,471-486 ,606-621 ,640-655 ,674-688
Function
Function in SwissProt
Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes (PubMed:22466610, PubMed:22466611, PubMed:22466612). Facilitates the ubiquitination of the elongating form of RNA polymerase II (RNA pol IIo) at DNA damage sites, thereby promoting RNA pol IIo backtracking and access by the TC-NER machinery to lesion sites (PubMed:22466611, PubMed:32142649). Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome (PubMed:22466611, PubMed:22466612). Also facilitates transfer of TFIIH to RNA polymerase II (PubMed:32142649). Not involved in processing oxidative damage (PubMed:22466612).