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IID00842
 UniprotQ4VCS5
ProteinAngiomotin
GeneAMOT
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1084
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 100-114 Hetero dimer : IID00114Complex
 Evidence NMR 7lp5 A Reference
       Region 7lp5 A 100-114 order
       Region 7lp5 A 100-100 high_rmsd
Seq 169-188 Hetero dimer : IID00301Complex
 Evidence X-RAY 7nma P Reference
       Region 7nma P 169-170 disorder
       Region 7nma P 171-178 order
       Region 7nma P 179-181 disorder
 Evidence X-RAY 7nmw P Reference
       Region 7nmw P 169-171 disorder
       Region 7nmw P 172-178 order
       Region 7nmw P 179-181 disorder
 Evidence X-RAY 7nmx P Reference
       Region 7nmx P 169-171 disorder
       Region 7nmx P 172-178 order
       Region 7nmx P 179-181 disorder
 Evidence X-RAY 7nn2 P Reference
       Region 7nn2 P 169-171 disorder
       Region 7nn2 P 172-178 order
       Region 7nn2 P 179-181 disorder
 Evidence X-RAY 7nnd P Reference
       Region 7nnd P 169-171 disorder
       Region 7nnd P 172-180 order
       Region 7nnd P 181-181 disorder
 Evidence X-RAY 7nne P Reference
       Region 7nne P 169-170 disorder
       Region 7nne P 171-179 order
       Region 7nne P 180-181 disorder
 Evidence X-RAY 7np2 P Reference
       Region 7np2 P 169-170 disorder
       Region 7np2 P 171-178 order
       Region 7np2 P 179-188 disorder
 Evidence X-RAY 7npb P Reference
       Region 7npb P 169-170 disorder
       Region 7npb P 171-179 order
       Region 7npb P 180-188 disorder
 Evidence X-RAY 7npg P Reference
       Region 7npg P 169-171 disorder
       Region 7npg P 172-179 order
       Region 7npg P 180-188 disorder
 Evidence X-RAY 7oqg P Reference
       Region 7oqg P 169-171 disorder
       Region 7oqg P 172-177 order
       Region 7oqg P 178-181 disorder
 Evidence X-RAY 7oqj P Reference
       Region 7oqj P 169-171 disorder
       Region 7oqj P 172-177 order
       Region 7oqj P 178-181 disorder
 Evidence X-RAY 7oqs P Reference
       Region 7oqs P 169-170 disorder
       Region 7oqs P 171-178 order
       Region 7oqs P 179-181 disorder
 Evidence X-RAY 7oqu P Reference
       Region 7oqu P 169-171 disorder
       Region 7oqu P 172-177 order
       Region 7oqu P 178-181 disorder
 Evidence X-RAY 7oqw P Reference
       Region 7oqw P 169-172 disorder
       Region 7oqw P 173-177 order
       Region 7oqw P 178-181 disorder
Seq 233-247 Hetero hexamer : IID00114Complex
 Evidence X-RAY 7lp2 F Reference
       Region 7lp2 F 233-247 order
 Evidence X-RAY 7lp2 D Reference
       Region 7lp2 D 233-235 disorder
       Region 7lp2 D 236-247 order
 Evidence X-RAY 7lp2 B Reference
       Region 7lp2 B 233-236 disorder
       Region 7lp2 B 237-247 order
Seq 234-247 Hetero tetramer : IID00114Complex
 Evidence X-RAY 7lp3 D Reference
       Region 7lp3 D 234-247 order
 Evidence X-RAY 7lp3 B Reference
       Region 7lp3 B 234-247 order
Seq 272-293 Hetero tetramer : Q5SXA9
 Evidence X-RAY 6jjx D Reference
       Region 6jjx D 272-277 disorder
       Region 6jjx D 278-293 order
 Evidence X-RAY 6jjx C Reference
       Region 6jjx C 272-276 disorder
       Region 6jjx C 277-291 order
       Region 6jjx C 292-293 disorder
SeqProS predicted 233-247 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc; PPxY motif - WW domain interaction Hetero tetramer : IID00114Complex
       Region 7lp3 B 234-247 order
       Region 7lp3 D 234-247 order
SeqProS predicted 233-247 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc; PPxY motif - WW domain interaction Hetero hexamer : IID00114Complex
       Region 7lp2 B 237-247 order
       Region 7lp2 D 236-247 order
       Region 7lp2 F 233-247 order
SeqProS predicted 277-293 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc; PPxY motif - WW domain interaction Hetero tetramer : Q5SXA9
       Region 6jjx C 277-291 order
       Region 6jjx D 278-293 order
Seqphosphorylation
    714-714 Phosphoserine
 
Prediction
NeProc
Disorder 1-11,25-430,634-656,698-726,755-1084
Order 12-24,431-633,657-697,727-754
ProS 25-42,74-89,103-114,129-134,161-189,259-265,278-294,427-430,634-642,654-656,703-712,721-726,755-773,783-792,854-868,1039-1054,1074-1084
AlphaFold
Disorder 1-12,27-27,41-106,118-174,185-426,524-529,644-657,705-721,770-1084
Order 13-26,28-40,107-117,175-184,427-523,530-643,658-704,722-769
SEG 43-57 ,309-333 ,376-403 ,550-559 ,585-596 ,620-644 ,795-808 ,837-852 ,875-1029
Function
Function in SwissProt
Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.
Biological Process
Diagram with PDB data
AMOT/NEDD4LStructure of Nedd4L WW3 domain
AMOT/WWC1Crystal Structure of KIBRA and Angiomotin complex
AMOT/SFNCrystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide