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IID00843
 UniprotQ53EZ4
ProteinCentrosomal protein of 55 kDa
GeneCEP55
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
464
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 160-217 Hetero trimer : IID00849Complex
 Evidence X-RAY 3wut A Reference
       Region 3wut A 160-211 order
       Region 3wut A 212-217 disorder
 Evidence X-RAY 3wut B Reference
       Region 3wut B 160-167 disorder
       Region 3wut B 168-211 order
       Region 3wut B 212-217 disorder
 Evidence X-RAY 3wut D Reference
       Region 3wut D 160-209 order
       Region 3wut D 210-217 disorder
 Evidence X-RAY 3wut E Reference
       Region 3wut E 160-209 order
       Region 3wut E 210-217 disorder
 Evidence X-RAY 3wut G Reference
       Region 3wut G 160-210 order
       Region 3wut G 211-217 disorder
 Evidence X-RAY 3wut H Reference
       Region 3wut H 160-208 order
       Region 3wut H 209-217 disorder
 Evidence X-RAY 3wut J Reference
       Region 3wut J 160-167 disorder
       Region 3wut J 168-211 order
       Region 3wut J 212-217 disorder
 Evidence X-RAY 3wut K Reference
       Region 3wut K 160-165 disorder
       Region 3wut K 166-208 order
       Region 3wut K 209-217 disorder
 Evidence X-RAY 3wuu A Reference
       Region 3wuu A 160-209 order
       Region 3wuu A 210-217 disorder
 Evidence X-RAY 3wuu B Reference
       Region 3wuu B 160-208 order
       Region 3wuu B 209-217 disorder
 Evidence X-RAY 3wuu D Reference
       Region 3wuu D 160-167 disorder
       Region 3wuu D 168-211 order
       Region 3wuu D 212-217 disorder
 Evidence X-RAY 3wuu E Reference
       Region 3wuu E 160-167 disorder
       Region 3wuu E 168-211 order
       Region 3wuu E 212-217 disorder
 Evidence X-RAY 3wuu G Reference
       Region 3wuu G 160-164 disorder
       Region 3wuu G 165-210 order
       Region 3wuu G 211-217 disorder
 Evidence X-RAY 3wuu H Reference
       Region 3wuu H 160-161 disorder
       Region 3wuu H 162-209 order
       Region 3wuu H 210-217 disorder
 Evidence X-RAY 3wuu J Reference
       Region 3wuu J 160-210 order
       Region 3wuu J 211-217 disorder
 Evidence X-RAY 3wuu K Reference
       Region 3wuu K 160-209 order
       Region 3wuu K 210-217 disorder
Seq 160-217 Hetero trimer : IID00852Complex
 Evidence X-RAY 3e1r A Reference
       Region 3e1r A 160-164 disorder
       Region 3e1r A 165-210 order
       Region 3e1r A 211-217 disorder
 Evidence X-RAY 3e1r B Reference
       Region 3e1r B 160-166 disorder
       Region 3e1r B 167-208 order
       Region 3e1r B 209-217 disorder
 Evidence X-RAY 3wuv A Reference
       Region 3wuv A 160-210 order
       Region 3wuv A 211-217 disorder
 Evidence X-RAY 3wuv B Reference
       Region 3wuv B 160-215 order
       Region 3wuv B 216-217 disorder
 Evidence X-RAY 3wuv D Reference
       Region 3wuv D 160-209 order
       Region 3wuv D 210-217 disorder
 Evidence X-RAY 3wuv E Reference
       Region 3wuv E 160-209 order
       Region 3wuv E 210-217 disorder
 Evidence X-RAY 3wuv G Reference
       Region 3wuv G 160-209 order
       Region 3wuv G 210-217 disorder
 Evidence X-RAY 3wuv H Reference
       Region 3wuv H 160-209 order
       Region 3wuv H 210-217 disorder
 Evidence X-RAY 3wuv J Reference
       Region 3wuv J 160-210 order
       Region 3wuv J 211-217 disorder
 Evidence X-RAY 3wuv K Reference
       Region 3wuv K 160-216 order
       Region 3wuv K 217-217 disorder
 Evidence X-RAY 3wuv M Reference
       Region 3wuv M 160-210 order
       Region 3wuv M 211-217 disorder
 Evidence X-RAY 3wuv N Reference
       Region 3wuv N 160-209 order
       Region 3wuv N 210-217 disorder
 Evidence X-RAY 3wuv P Reference
       Region 3wuv P 160-212 order
       Region 3wuv P 213-217 disorder
 Evidence X-RAY 3wuv Q Reference
       Region 3wuv Q 160-216 order
       Region 3wuv Q 217-217 disorder
Seqphosphorylation
    428-428 Phosphoserine; by CDK1 and MAPK1
    96-96 Phosphoserine
    425-425 Phosphoserine; by CDK1 and MAPK1
    436-436 Phosphoserine; by PLK1
    430-430 Phosphothreonine
 
Prediction
NeProc
Disorder 1-62,91-103,153-186,196-240,290-296,346-362,398-430
Order 63-90,104-152,187-195,241-289,297-345,363-397,431-464
ProS 5-17,25-44,55-62,91-103,166-186,196-214,230-240,290-296,346-362,401-408,416-423
AlphaFold
Disorder 1-24,47-49,150-163,213-229,399-435
Order 25-46,50-149,164-212,230-398,436-464
SEG 97-116 ,317-330
Function
Function in SwissProt
Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986).
Biological Process
See also
Diagram with PDB data
TEX14/CEP55Structure basis of inactivating cell abscission with chimera peptide 1
PDCD6IP/CEP55Structure basis of inactivating cell abscission with chimera peptide 2