Search Keyword:


Search option:


IID00846
UniprotQ6ZYL4
ProteinGeneral transcription factor IIH subunit 5
GeneGTF2H5
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
71
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-71 Homo dimer :
 Evidence NMR 2jnj B Reference
       Region 2jnj B 1-71 order
       Region 2jnj B 65-71 high_rmsd
 Evidence NMR 2jnj A Reference
       Region 2jnj A 1-71 order
       Region 2jnj A 65-71 high_rmsd
Seq 3-71 Monomer :
 Evidence X-RAY 1ydl A Reference
       Region 1ydl A 3-71 order
Seqphosphorylation
    69-69 Phosphothreonine
 
Prediction
NeProc
Disorder 68-71
Order 1-67
ProS 68-71
AlphaFold
Disorder 1-5,26-31,57-58,60-61,63-71
Order 6-25,32-56,59-59,62-62
Pfam Hmmer
PF06331 1-70 1.6e-43
Function
Function in SwissProt
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell.
Biological Process
See also
Diagram with PDB data
XPA/ERCC1Solution structure of a ERCC1-XPA heterodimer
XPC/GTF2H1Solution structure of the complex between XPC acidic domain and TFIIH p62 PH domain