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IID00847
UniprotQ7LBR1
ProteinCharged multivesicular body protein 1b
GeneCHMP1B
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
199
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 148-197 Hetero dimer : Q9UBP0
 Evidence X-RAY 3eab G Reference
       Region 3eab G 148-163 order
       Region 3eab G 164-172 disorder
       Region 3eab G 173-196 order
       Region 3eab G 197-197 disorder
 Evidence X-RAY 3eab H Reference
       Region 3eab H 148-149 disorder
       Region 3eab H 150-163 order
       Region 3eab H 164-172 disorder
       Region 3eab H 173-197 order
 Evidence X-RAY 3eab I Reference
       Region 3eab I 148-164 order
       Region 3eab I 165-173 disorder
       Region 3eab I 174-197 order
 Evidence X-RAY 3eab J Reference
       Region 3eab J 148-163 order
       Region 3eab J 164-173 disorder
       Region 3eab J 174-194 order
       Region 3eab J 195-197 disorder
 Evidence X-RAY 3eab K Reference
       Region 3eab K 148-148 disorder
       Region 3eab K 149-163 order
       Region 3eab K 164-173 disorder
       Region 3eab K 174-196 order
       Region 3eab K 197-197 disorder
 Evidence X-RAY 3eab L Reference
       Region 3eab L 148-162 order
       Region 3eab L 163-173 disorder
       Region 3eab L 174-195 order
       Region 3eab L 196-197 disorder
Seq 176-199 Hetero trimer : IID00881Complex
 Evidence X-RAY 4txr B Reference
       Region 4txr B 176-184 disorder
       Region 4txr B 185-199 order
Seq 176-199 Hetero dimer : IID00881Complex
 Evidence X-RAY 4txq C Reference
       Region 4txq C 176-185 disorder
       Region 4txq C 186-198 order
       Region 4txq C 199-199 disorder
 Evidence X-RAY 4txq D Reference
       Region 4txq D 176-182 disorder
       Region 4txq D 183-199 order
SeqProS possible 173-197 Same region of the homolog (Q9Y3E7, CHMP3) is disordered in the free state (PubMed=21827950). Hetero dimer : Q9UBP0
       Region 3eab G 173-196 order
       Region 3eab H 173-197 order
       Region 3eab I 174-197 order
       Region 3eab J 174-194 order
       Region 3eab K 174-196 order
       Region 3eab L 174-195 order
SeqProS possible 183-199 Same region of the homolog (Q9Y3E7, CHMP3) is disordered in the free state (PubMed=21827950). Hetero dimer : IID00881Complex
       Region 4txq C 186-198 order
       Region 4txq D 183-199 order
SeqProS possible 183-199 Same region of the homolog (Q9Y3E7, CHMP3) is disordered in the free state (PubMed=21827950). Hetero trimer : IID00881Complex
       Region 4txr B 185-199 order
 
Prediction
NeProc
Disorder 1-14,85-107,136-199
Order 15-84,108-135
ProS 1-14,85-107,147-169,185-199
AlphaFold
Disorder 1-1,132-132,135-143,162-185,198-199
Order 2-131,133-134,144-161,186-197
Pfam Hmmer
PF03357 6-176 1.3e-30
SEG 22-42 ,135-144
Function
Function in SwissProt
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells. Involved in HIV-1 p6- and p9-dependent virus release.