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IID00852
 UniprotQ8WUM4
ProteinProgrammed cell death 6-interacting protein
GenePDCD6IP
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
868
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-359 Monomer :
 Evidence X-RAY 2oew A Reference
       Region 2oew A 1-358 order
       Region 2oew A 359-359 disorder
Seq 1-359 Hetero dimer : IID00860Complex
 Evidence X-RAY 3c3r A Reference
       Region 3c3r A 1-1 disorder
       Region 3c3r A 2-358 order
       Region 3c3r A 359-359 disorder
 Evidence X-RAY 5v3r A Reference
       Region 5v3r A 1-1 disorder
       Region 5v3r A 2-358 order
       Region 5v3r A 359-359 disorder
 Evidence X-RAY 5wa1 A Reference
       Region 5wa1 A 1-358 order
Seq 1-359 Hetero dimer : P04862
 Evidence X-RAY 6kp3 A Reference
       Region 6kp3 A 1-1 disorder
       Region 6kp3 A 2-358 order
       Region 6kp3 A 359-359 disorder
Seq 1-359 Hetero dimer : IID00873Complex
 Evidence X-RAY 3c3o A Reference
       Region 3c3o A 1-1 disorder
       Region 3c3o A 2-358 order
       Region 3c3o A 359-359 disorder
Seq 1-359 Hetero dimer : IID00876Complex
 Evidence X-RAY 3c3q A Reference
       Region 3c3q A 1-1 disorder
       Region 3c3q A 2-358 order
       Region 3c3q A 359-359 disorder
Seq 1-698 Hetero dimer : P05893
 Evidence X-RAY 2xs1 A Reference
       Region 2xs1 A 1-1 disorder
       Region 2xs1 A 2-698 order
Seq 1-698 Monomer :
 Evidence X-RAY 2oev A Reference
       Region 2oev A 1-1 disorder
       Region 2oev A 2-698 order
Seq 1-698 Hetero dimer : Q02843
 Evidence X-RAY 2xs8 A Reference
       Region 2xs8 A 1-1 disorder
       Region 2xs8 A 2-698 order
Seq 2-698 Hetero dimer : P69732
 Evidence X-RAY 2r03 A Reference
       Region 2r03 A 2-698 order
Seq 2-698 Hetero dimer : Q9WC62
 Evidence X-RAY 2r02 A Reference
       Region 2r02 A 2-698 order
Seq 2-698 Hetero dimer : P35962
 Evidence X-RAY 2r05 A Reference
       Region 2r05 A 2-698 order
Seq 355-708 Monomer :
 Evidence X-RAY 2ojq A Reference
       Region 2ojq A 360-702 order
 Evidence X-RAY 4jjy A Reference
       Region 4jjy A 355-360 disorder
       Region 4jjy A 361-701 order
       Region 4jjy A 702-708 disorder
 Evidence X-RAY 4jjy B Reference
       Region 4jjy B 355-360 disorder
       Region 4jjy B 361-701 order
       Region 4jjy B 702-708 disorder
Seq 360-702 Homo dimer :
 Evidence X-RAY 2oex B Reference
       Region 2oex B 360-361 disorder
       Region 2oex B 362-702 order
 Evidence X-RAY 2oex A Reference
       Region 2oex A 360-360 disorder
       Region 2oex A 361-702 order
Seq 797-809 Hetero trimer : IID00843Complex
 Evidence X-RAY 3e1r C Reference
       Region 3e1r C 797-809 order
 Evidence X-RAY 3wuv C Reference
       Region 3wuv C 797-806 order
 Evidence X-RAY 3wuv F Reference
       Region 3wuv F 797-806 order
 Evidence X-RAY 3wuv I Reference
       Region 3wuv I 797-806 order
 Evidence X-RAY 3wuv L Reference
       Region 3wuv L 797-806 order
 Evidence X-RAY 3wuv O Reference
       Region 3wuv O 797-806 order
 Evidence X-RAY 3wuv R Reference
       Region 3wuv R 797-806 order
Seq 799-812 Hetero dimer : O75340
 Evidence X-RAY 2zne C Reference
       Region 2zne C 799-799 disorder
       Region 2zne C 800-812 order
 Evidence X-RAY 2zne D Reference
       Region 2zne D 799-810 order
       Region 2zne D 811-812 disorder
SeqProS predicted 797-809 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero trimer : IID00843Complex
       Region 3e1r C 797-809 order
       Region 3wuv C 797-806 order
       Region 3wuv F 797-806 order
       Region 3wuv I 797-806 order
       Region 3wuv L 797-806 order
       Region 3wuv O 797-806 order
       Region 3wuv R 797-806 order
SeqProS predicted 799-812 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : O75340
       Region 2zne C 800-812 order
       Region 2zne D 799-810 order
Seqphosphorylation
    479-479 Phosphothreonine
    481-481 Phosphoserine
    730-730 Phosphoserine
    738-738 Phosphothreonine
    741-741 Phosphothreonine
Seqacetylation
    2-2 N-acetylalanine
    215-215 N6-acetyllysine
 
Prediction
NeProc
Disorder 536-544,706-868
Order 1-535,545-705
ProS 706-709,865-868
AlphaFold
Disorder 1-2,101-108,716-868
Order 3-100,109-715
Pfam Hmmer
PF03097 3-382 1.4e-176
SEG 448-462 ,548-559 ,736-769 ,778-811 ,839-868
Function
Function in SwissProt
(Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses).
Biological Process
Diagram with PDB data
PDCD6IP/CEP55Structure basis of inactivating cell abscission with chimera peptide 2
See also
Diagram with PDB data
CHMP4C/PDCD6IPALIX BRO1 CHMP4C complex