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IID00855
 UniprotQ92783
ProteinSignal transducing adapter molecule 1
GeneSTAM
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
540
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 4-143 Hetero heptamer : P0CG48
 Evidence X-RAY 3ldz D Reference
       Region 3ldz D 4-143 order
 Evidence X-RAY 3ldz C Reference
       Region 3ldz C 4-143 order
 Evidence X-RAY 3ldz B Reference
       Region 3ldz B 4-143 order
 Evidence X-RAY 3ldz A Reference
       Region 3ldz A 4-143 order
Seq 207-267 Monomer :
 Evidence NMR 2l0a A Reference
       Region 2l0a A 207-267 order
       Region 2l0a A 207-210 high_rmsd
Seq 301-377 Hetero dimer : IID00751Complex
 Evidence X-RAY 3f1i S Reference
       Region 3f1i S 301-377 order
 Evidence X-RAY 3f1i C Reference
       Region 3f1i C 301-337 disorder
       Region 3f1i C 338-361 order
       Region 3f1i C 362-377 disorder
Seqphosphorylation
    384-384 Phosphotyrosine
    381-381 Phosphotyrosine
    198-198 Phosphotyrosine
    156-156 Phosphoserine
 
Prediction
NeProc
Disorder 147-224,257-299,318-325,377-540
Order 1-146,225-256,300-317,326-376
ProS 164-167,201-224,257-268,318-325,537-540
AlphaFold
Disorder 1-4,145-170,187-212,269-300,321-323,378-540
Order 5-144,171-186,213-268,301-320,324-377
Pfam Hmmer
PF00790 7-139 9.9e-69
PF02809 170-187 0.00027
PF00018 213-267 3.1e-22
SEG 191-206 ,425-440 ,482-493 ,519-536
Function
Function in SwissProt
(Microbial infection) Plays an important role in Dengue virus entry.
Biological Process
See also
Diagram with PDB data
HGS/STAMHuman ESCRT-0 Core Complex
VPS36/SNF8/VPS25/VPS25Integrated structural and functional model of the human ESCRT-II complex
CHMP6/VPS25Crystal structure of the human VPS25-VPS20 subcomplex
TSG101/HGSCrystal Structure of the Tsg101 UEV domain in complex with a human HRS PSAP peptide