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IID00856
 UniprotQ92833
ProteinProtein Jumonji
GeneJARID2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1246
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 110-120 Hetero pentamer : IID00530Complex,IID00727Complex
 Evidence X-RAY 5ls6 S Reference
       Region 5ls6 S 110-110 disorder
       Region 5ls6 S 111-120 order
Seq 110-120 Hetero pentamer : IID00530Complex,IID00727Complex
 Evidence X-RAY 5ls6 Q Reference
       Region 5ls6 Q 110-110 disorder
       Region 5ls6 Q 111-120 order
Seq 110-120 Hetero pentamer : IID00530Complex,IID00727Complex
 Evidence X-RAY 5ls6 T Reference
       Region 5ls6 T 110-110 disorder
       Region 5ls6 T 111-120 order
Seq 110-120 Hetero pentamer : IID00530Complex,IID00727Complex
 Evidence X-RAY 5ls6 R Reference
       Region 5ls6 R 110-110 disorder
       Region 5ls6 R 111-120 order
Seq 110-121 Hetero pentamer : IID00530Complex,IID00727Complex
 Evidence X-RAY 5hyn E Reference
       Region 5hyn E 110-120 order
       Region 5hyn E 121-121 disorder
 Evidence X-RAY 5hyn J Reference
       Region 5hyn J 110-110 disorder
       Region 5hyn J 111-120 order
       Region 5hyn J 121-121 disorder
 Evidence X-RAY 5hyn P Reference
       Region 5hyn P 110-111 disorder
       Region 5hyn P 112-120 order
       Region 5hyn P 121-121 disorder
 Evidence X-RAY 5hyn U Reference
       Region 5hyn U 110-110 disorder
       Region 5hyn U 111-120 order
       Region 5hyn U 121-121 disorder
Seq 147-165 Hetero octamer : IID00480Complex,IID00725Complex
 Evidence X-RAY 6nq3 D Reference
       Region 6nq3 D 147-148 disorder
       Region 6nq3 D 149-165 order
 Evidence X-RAY 6nq3 H Reference
       Region 6nq3 H 147-148 disorder
       Region 6nq3 H 149-165 order
Seq 147-165 Hetero tetramer : IID00725Complex,Q6ZN18
 Evidence X-RAY 5wai D Reference
       Region 5wai D 147-149 disorder
       Region 5wai D 150-164 order
       Region 5wai D 165-165 disorder
 Evidence X-RAY 5wai H Reference
       Region 5wai H 147-149 disorder
       Region 5wai H 150-164 order
       Region 5wai H 165-165 disorder
SeqProS predicted 110-120 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero pentamer : IID00530Complex,IID00727Complex
       Region 5hyn E 110-120 order
       Region 5hyn J 111-120 order
       Region 5hyn P 112-120 order
       Region 5hyn U 111-120 order
SeqProS predicted 110-120 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero pentamer : IID00530Complex,IID00727Complex
       Region 5ls6 R 111-120 order
SeqProS predicted 110-120 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero pentamer : IID00530Complex,IID00727Complex
       Region 5ls6 S 111-120 order
SeqProS predicted 110-120 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero pentamer : IID00530Complex,IID00727Complex
       Region 5ls6 Q 111-120 order
SeqProS predicted 110-120 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero pentamer : IID00530Complex,IID00727Complex
       Region 5ls6 T 111-120 order
Seqphosphorylation
    78-78 Phosphoserine
    455-455 Phosphoserine
Seqacetylation
    378-378 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-8,45-549,722-806,1115-1120,1214-1246
Order 9-44,550-721,807-1114,1125-1213
ProS 45-70,80-102,107-133,144-179,220-229,335-353,405-411,434-440,539-549,722-806,1217-1221
AlphaFold
Disorder 1-21,23-23,47-152,177-553,737-806,808-808,970-970,972-972,1112-1136,1202-1246
Order 22-22,24-46,153-176,554-736,807-807,809-969,971-971,973-1111,1137-1201
Pfam Hmmer
PF02375 558-602 2.3e-25
PF01388 618-728 3.4e-46
PF02373 916-1031 3e-49
PF02928 1139-1193 1.4e-27
SEG 86-99 ,181-195 ,423-438 ,456-476 ,540-553 ,793-802 ,1234-1246
Function
Function in SwissProt
Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:20075857). Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin (PubMed:20075857, PubMed:29499137, PubMed:31959557). Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (PubMed:20075857). In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (By similarity). Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (By similarity). Participates in the negative regulation of cell proliferation signaling (By similarity). Does not have histone demethylase activity (By similarity).