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IID00858
 UniprotQ92889
ProteinDNA repair endonuclease XPF
GeneERCC4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
916
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 834-916 Hetero dimer : IID00364Complex
 Evidence NMR 1z00 B Reference
       Region 1z00 B 834-916 order
       Region 1z00 B 912-916 high_rmsd
 Evidence X-RAY 2a1j A Reference
       Region 2a1j A 848-909 order
 Evidence NMR 2mut B Reference
       Region 2mut B 834-916 order
       Region 2mut B 834-835 high_rmsd
       Region 2mut B 911-916 high_rmsd
Seq 834-916 Homo dimer :
 Evidence NMR 2aq0 A Reference
       Region 2aq0 A 834-916 order
       Region 2aq0 A 913-916 high_rmsd
 Evidence NMR 2aq0 B Reference
       Region 2aq0 B 834-916 order
       Region 2aq0 B 834-837 high_rmsd
       Region 2aq0 B 912-916 high_rmsd
 Evidence NMR 2kn7 A Reference
       Region 2kn7 A 842-908 order
 Evidence NMR 2kn7 D Reference
       Region 2kn7 D 842-908 order
       Region 2kn7 D 908-908 high_rmsd
Seqphosphorylation
    764-764 Phosphoserine
    521-521 Phosphoserine
Seqacetylation
    911-911 N6-acetyllysine
    289-289 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-10,350-367,456-546,647-676,909-916
Order 11-349,368-455,547-646,677-833,840-908
ProS 456-466,481-494,508-518,527-546,647-673
AlphaFold
Disorder 1-11,245-251,261-261,317-324,346-371,398-403,441-550,559-559,650-680,770-781,828-828,830-846,907-908,910-916
Order 12-244,252-260,262-316,325-345,372-397,404-440,551-558,560-649,681-769,782-827,829-829,847-906,909-909
Pfam Hmmer
PF02732 683-763 4.9e-47
SEG 350-372 ,480-495 ,502-529
Function
Function in SwissProt
Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair.
Biological Process
See also
Diagram with PDB data
XPA/ERCC1Solution structure of a ERCC1-XPA heterodimer