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IID00859
 UniprotQ96AP0
ProteinAdrenocortical dysplasia protein homolog
GeneACD
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
458
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 4-164 Monomer :
 Evidence X-RAY 5i2x A Reference
       Region 5i2x A 4-83 order
       Region 5i2x A 85-154 order
       Region 5i2x A 155-164 disorder
 Evidence X-RAY 5i2x B Reference
       Region 5i2x B 4-39 order
       Region 5i2x B 40-53 disorder
       Region 5i2x B 54-81 order
       Region 5i2x B 82-83 disorder
       Region 5i2x B 85-85 disorder
       Region 5i2x B 86-153 order
       Region 5i2x B 154-164 disorder
 Evidence X-RAY 5i2y A Reference
       Region 5i2y A 4-154 order
       Region 5i2y A 155-164 disorder
 Evidence X-RAY 5i2y B Reference
       Region 5i2y B 4-39 order
       Region 5i2y B 40-53 disorder
       Region 5i2y B 54-81 order
       Region 5i2y B 82-85 disorder
       Region 5i2y B 86-154 order
       Region 5i2y B 155-164 disorder
Seq 4-164 Homo dimer :
 Evidence X-RAY 2i46 B Reference
       Region 2i46 B 4-39 order
       Region 2i46 B 40-53 disorder
       Region 2i46 B 54-81 order
       Region 2i46 B 82-85 disorder
       Region 2i46 B 86-155 order
       Region 2i46 B 156-164 disorder
 Evidence X-RAY 2i46 A Reference
       Region 2i46 A 4-155 order
       Region 2i46 A 156-164 disorder
Seq 159-251 Hetero octamer : IID00885Complex
 Evidence X-RAY 7s1t K Reference
       Region 7s1t K 159-166 disorder
       Region 7s1t K 167-240 order
       Region 7s1t K 241-251 disorder
 Evidence X-RAY 7s1t H Reference
       Region 7s1t H 159-166 disorder
       Region 7s1t H 167-240 order
       Region 7s1t H 241-251 disorder
 Evidence X-RAY 7s1t E Reference
       Region 7s1t E 159-166 disorder
       Region 7s1t E 167-240 order
       Region 7s1t E 241-251 disorder
 Evidence X-RAY 7s1t B Reference
       Region 7s1t B 159-166 disorder
       Region 7s1t B 167-240 order
       Region 7s1t B 241-251 disorder
Seq 169-251 Hetero dimer : IID00885Complex
 Evidence X-RAY 5h65 B Reference
       Region 5h65 B 180-230 order
 Evidence X-RAY 5un7 B Reference
       Region 5un7 B 169-179 disorder
       Region 5un7 B 180-240 order
       Region 5un7 B 241-251 disorder
Seq 424-458 Hetero trimer : IID00180Complex
 Evidence X-RAY 5xyf B Reference
       Region 5xyf B 424-447 order
       Region 5xyf B 448-458 disorder
Seqphosphorylation
    349-349 Phosphoserine
    25-25 Phosphoserine
 
Prediction
NeProc
Disorder 1-5,43-48,157-166,197-211,217-418,450-458
Order 6-21,28-38,49-156,167-196,212-216,423-449
ProS 203-211,217-240,252-263,403-418
AlphaFold
Disorder 1-7,83-84,156-166,175-175,177-177,192-229,237-237,239-406,408-409,414-420,429-433,447-458
Order 8-82,85-155,167-174,176-176,178-191,230-236,238-238,407-407,410-413,421-428,434-446
SEG 261-283 ,293-307
Function
Function in SwissProt
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.