Structure
atLeast majority ProS Experiment
:order disorder conflict PDB cluster ProS Pfam Domain SEG273
order/disorder by at least rule
disorder by at least rule
order/disorder by majority rule
Seq 206-228 Hetero 24mer : IID00868 Complex ,
IID00878 Complex ,
IID00890 Complex
Region 6vme T 206-222 order
Region 6vme T 223-228 disorder
Region 6vme R 206-224 order
Region 6vme R 225-228 disorder
Region 6vme Q 206-223 order
Region 6vme Q 224-228 disorder
Region 6vme P 206-225 order
Region 6vme P 226-228 disorder
Region 6vme D 206-223 order
Region 6vme D 224-228 disorder
Region 6vme A 206-223 order
Region 6vme A 224-228 disorder
Prediction
Function
Function in SwissProt
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor.
Biological Process
See also Diagram with PDB data VPS36/SNF8/VPS25/VPS25 Integrated structural and functional model of the human ESCRT-II complex CHMP6/VPS25 Crystal structure of the human VPS25-VPS20 subcomplex TSG101/HGS Crystal Structure of the Tsg101 UEV domain in complex with a human HRS PSAP peptide
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