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IID00862
UniprotQ96FZ7
ProteinCharged multivesicular body protein 6
GeneCHMP6
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
201
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 11-48 Hetero dimer : IID00869Complex
 Evidence X-RAY 3htu B Reference
       Region 3htu B 11-44 order
       Region 3htu B 45-48 disorder
 Evidence X-RAY 3htu D Reference
       Region 3htu D 11-45 order
       Region 3htu D 46-48 disorder
 Evidence X-RAY 3htu F Reference
       Region 3htu F 11-41 order
       Region 3htu F 42-48 disorder
 Evidence X-RAY 3htu H Reference
       Region 3htu H 11-45 order
       Region 3htu H 46-48 disorder
Seq 166-181 Hetero dimer : IID00334Complex
 Evidence NMR 2k3w B Reference
       Region 2k3w B 166-167 disorder
       Region 2k3w B 168-179 order
       Region 2k3w B 180-181 disorder
SeqProS predicted 168-179 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00334Complex
       Region 2k3w B 168-179 order
Seqphosphorylation
    130-130 Phosphothreonine
    119-119 Phosphoserine
 
Prediction
NeProc
Disorder 1-15,146-201
Order 16-145
ProS 1-6,153-177
AlphaFold
Disorder 1-11,167-201
Order 12-166
Pfam Hmmer
PF03357 18-178 4.4e-58
SEG 21-36 ,38-53 ,56-68 ,169-180
Function
Function in SwissProt
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.
Biological Process
Diagram with PDB data
CHMP6/VPS25Crystal structure of the human VPS25-VPS20 subcomplex
See also
Diagram with PDB data
VPS4A/CHMP6NMR structure of VPS4A-MIT-CHMP6