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IID00865
 UniprotQ96RK0
ProteinProtein capicua homolog
GeneCIC
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1608
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 21-48 Hetero dimer : IID00810Complex
 Evidence X-RAY 4j2l C Reference
       Region 4j2l C 21-45 order
       Region 4j2l C 46-48 disorder
 Evidence X-RAY 4j2l D Reference
       Region 4j2l D 21-45 order
       Region 4j2l D 46-48 disorder
Seq 28-48 Hetero dimer : IID00810Complex
 Evidence X-RAY 4j2j D Reference
       Region 4j2j D 28-29 disorder
       Region 4j2j D 30-44 order
       Region 4j2j D 45-48 disorder
 Evidence X-RAY 4j2j E Reference
       Region 4j2j E 28-28 disorder
       Region 4j2j E 29-45 order
       Region 4j2j E 46-48 disorder
 Evidence X-RAY 4j2j F Reference
       Region 4j2j F 28-28 disorder
       Region 4j2j F 29-43 order
       Region 4j2j F 44-48 disorder
Seq 34-48 Hetero dimer : IID00810Complex
 Evidence NMR 2m41 A Reference
       Region 2m41 A 34-48 order
Seq 170-177 Hetero tetramer : IID00793Complex
 Evidence X-RAY 6kzh Q Reference
       Region 6kzh Q 170-170 disorder
       Region 6kzh Q 171-175 order
       Region 6kzh Q 176-177 disorder
 Evidence X-RAY 6kzh C Reference
       Region 6kzh C 170-170 disorder
       Region 6kzh C 171-175 order
       Region 6kzh C 176-177 disorder
Seq 199-276 Homo tetramer :
 Evidence X-RAY 6jrp J Reference
       Region 6jrp J 199-272 order
       Region 6jrp J 273-276 disorder
 Evidence X-RAY 6jrp G Reference
       Region 6jrp G 199-272 order
       Region 6jrp G 273-276 disorder
 Evidence X-RAY 6jrp D Reference
       Region 6jrp D 199-272 order
       Region 6jrp D 273-276 disorder
 Evidence X-RAY 6jrp A Reference
       Region 6jrp A 199-272 order
       Region 6jrp A 273-276 disorder
Seq 298-305 Hetero tetramer : IID00793Complex
 Evidence X-RAY 6kzg Q Reference
       Region 6kzg Q 298-305 order
 Evidence X-RAY 6kzg C Reference
       Region 6kzg C 298-305 order
SeqProS predicted 171-175 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero tetramer : IID00793Complex
       Region 6kzh C 171-175 order
       Region 6kzh Q 171-175 order
SeqProS predicted 298-305 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero tetramer : IID00793Complex
       Region 6kzg C 298-305 order
       Region 6kzg Q 298-305 order
Seqphosphorylation
    1595-1595 Phosphoserine
    146-146 Phosphoserine
    173-173 Phosphoserine
    277-277 Phosphoserine
    362-362 Phosphoserine
    431-431 Phosphoserine
    436-436 Phosphoserine
    496-496 Phosphoserine
    700-700 Phosphoserine
    721-721 Phosphoserine
    739-739 Phosphoserine
    1409-1409 Phosphoserine
    1402-1402 Phosphoserine
    1398-1398 Phosphothreonine
    1397-1397 Phosphoserine
    1389-1389 Phosphoserine
    1382-1382 Phosphoserine
    1378-1378 Phosphoserine
    1373-1373 Phosphoserine
    1351-1351 Phosphoserine
    1294-1294 Phosphoserine
    1291-1291 Phosphothreonine
Seqacetylation
    1268-1268 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-12,48-1608
Order 13-47
ProS 1-5,147-153,198-241,249-272,463-466,493-500,1340-1369,1430-1446,1475-1483,1498-1503
AlphaFold
Disorder 1-198,270-1461,1523-1608
Order 199-269,1462-1522
Pfam Hmmer
PF00505 200-268 4.6e-19
SEG 103-115 ,396-414 ,473-486 ,508-521 ,530-547 ,567-588 ,772-777 ,784-802 ,839-861 ,941-953 ,1067-1082 ,1097-1118 ,1121-1135 ,1138-1157 ,1227-1258 ,1287-1316 ,1329-1340 ,1409-1422 ,1487-1498 ,1528-1569 ,1573-1587 ,1590-1607
Function
Function in SwissProt
Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development.