Search Keyword:


Search option:


IID00866
 UniprotQ96RR4
ProteinCalcium/calmodulin-dependent protein kinase kinase 2
GeneCAMKK2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
588
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 97-104 Hetero octamer : IID00061Complex
 Evidence X-RAY 6eww E Reference
       Region 6eww E 97-104 order
 Evidence X-RAY 6eww F Reference
       Region 6eww F 97-104 order
 Evidence X-RAY 6eww G Reference
       Region 6eww G 97-104 order
 Evidence X-RAY 6eww H Reference
       Region 6eww H 97-103 order
       Region 6eww H 104-104 disorder
Seq 97-104 Hetero dimer : IID00301Complex
 Evidence X-RAY 6y3o P Reference
       Region 6y3o P 97-97 disorder
       Region 6y3o P 98-102 order
       Region 6y3o P 103-104 disorder
Seq 97-104 Hetero tetramer : IID00816Complex
 Evidence X-RAY 6y4k E Reference
       Region 6y4k E 97-104 order
 Evidence X-RAY 6y4k F Reference
       Region 6y4k F 97-97 disorder
       Region 6y4k F 98-104 order
 Evidence X-RAY 6y6b C Reference
       Region 6y6b C 97-97 disorder
       Region 6y6b C 98-104 order
 Evidence X-RAY 6y6b D Reference
       Region 6y6b D 97-104 order
Seq 149-465 Monomer :
 Evidence X-RAY 2zv2 A Reference
       Region 2zv2 A 158-159 disorder
       Region 2zv2 A 160-173 order
       Region 2zv2 A 174-175 disorder
       Region 2zv2 A 176-199 order
       Region 2zv2 A 200-230 disorder
       Region 2zv2 A 231-448 order
 Evidence X-RAY 5uy6 A Reference
       Region 5uy6 A 161-213 order
       Region 5uy6 A 214-221 disorder
       Region 5uy6 A 222-448 order
       Region 5uy6 A 449-449 disorder
 Evidence X-RAY 5uyj A Reference
       Region 5uyj A 161-212 order
       Region 5uyj A 213-222 disorder
       Region 5uyj A 223-449 order
 Evidence X-RAY 5vt1 A Reference
       Region 5vt1 A 161-205 order
       Region 5vt1 A 206-226 disorder
       Region 5vt1 A 227-360 order
       Region 5vt1 A 361-363 disorder
       Region 5vt1 A 364-448 order
       Region 5vt1 A 449-449 disorder
 Evidence X-RAY 5yv8 A Reference
       Region 5yv8 A 158-159 disorder
       Region 5yv8 A 160-199 order
       Region 5yv8 A 200-228 disorder
       Region 5yv8 A 229-448 order
 Evidence X-RAY 5yv9 A Reference
       Region 5yv9 A 158-159 disorder
       Region 5yv9 A 160-199 order
       Region 5yv9 A 200-228 disorder
       Region 5yv9 A 229-448 order
 Evidence X-RAY 5yva A Reference
       Region 5yva A 158-159 disorder
       Region 5yva A 160-199 order
       Region 5yva A 200-228 disorder
       Region 5yva A 229-448 order
 Evidence X-RAY 5yvb A Reference
       Region 5yvb A 158-159 disorder
       Region 5yvb A 160-199 order
       Region 5yvb A 200-228 disorder
       Region 5yvb A 229-448 order
 Evidence X-RAY 5yvc A Reference
       Region 5yvc A 158-159 disorder
       Region 5yvc A 160-199 order
       Region 5yvc A 200-228 disorder
       Region 5yvc A 229-448 order
 Evidence X-RAY 6bku A Reference
       Region 6bku A 162-206 order
       Region 6bku A 207-229 disorder
       Region 6bku A 230-448 order
       Region 6bku A 449-449 disorder
 Evidence X-RAY 6ble A Reference
       Region 6ble A 161-204 order
       Region 6ble A 205-229 disorder
       Region 6ble A 230-448 order
       Region 6ble A 449-449 disorder
 Evidence X-RAY 6bql A Reference
       Region 6bql A 161-211 order
       Region 6bql A 212-223 disorder
       Region 6bql A 224-448 order
       Region 6bql A 449-449 disorder
 Evidence X-RAY 6bqp A Reference
       Region 6bqp A 161-203 order
       Region 6bqp A 204-229 disorder
       Region 6bqp A 230-448 order
       Region 6bqp A 449-449 disorder
 Evidence X-RAY 6bqq A Reference
       Region 6bqq A 161-203 order
       Region 6bqq A 204-221 disorder
       Region 6bqq A 222-412 order
       Region 6bqq A 413-413 disorder
       Region 6bqq A 414-448 order
       Region 6bqq A 449-449 disorder
 Evidence X-RAY 6brc A Reference
       Region 6brc A 161-204 order
       Region 6brc A 205-229 disorder
       Region 6brc A 230-448 order
       Region 6brc A 449-449 disorder
 Evidence X-RAY 6brc B Reference
       Region 6brc B 161-203 order
       Region 6brc B 204-231 disorder
       Region 6brc B 232-448 order
       Region 6brc B 449-449 disorder
 Evidence X-RAY 6cmj A Reference
       Region 6cmj A 149-160 disorder
       Region 6cmj A 161-205 order
       Region 6cmj A 221-463 order
       Region 6cmj A 464-465 disorder
 Evidence X-RAY 6cmj B Reference
       Region 6cmj B 149-160 disorder
       Region 6cmj B 161-205 order
       Region 6cmj B 221-462 order
       Region 6cmj B 463-465 disorder
Seq 508-514 Hetero octamer : IID00061Complex
 Evidence X-RAY 6ef5 Q Reference
       Region 6ef5 Q 508-514 order
 Evidence X-RAY 6ef5 S Reference
       Region 6ef5 S 508-514 order
Seq 508-515 Hetero tetramer : IID00816Complex
 Evidence X-RAY 6fel E Reference
       Region 6fel E 508-513 order
       Region 6fel E 514-515 disorder
 Evidence X-RAY 6fel F Reference
       Region 6fel F 508-513 order
       Region 6fel F 514-515 disorder
 Evidence X-RAY 6fel G Reference
       Region 6fel G 508-514 order
       Region 6fel G 515-515 disorder
 Evidence X-RAY 6fel H Reference
       Region 6fel H 508-513 order
       Region 6fel H 514-515 disorder
Seq 508-515 Hetero dimer : IID00301Complex
 Evidence X-RAY 6y8a P Reference
       Region 6y8a P 508-514 order
       Region 6y8a P 515-515 disorder
SeqProS predicted 97-104 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00301Complex
       Region 6y3o P 98-102 order
SeqProS predicted 97-104 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero tetramer : IID00816Complex
       Region 6y6b C 98-104 order
       Region 6y6b D 97-104 order
       Region 6y4k E 97-104 order
       Region 6y4k F 98-104 order
SeqProS predicted 97-104 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero octamer : IID00061Complex
       Region 6eww E 97-104 order
       Region 6eww F 97-104 order
       Region 6eww G 97-104 order
       Region 6eww H 97-103 order
SeqProS predicted 508-514 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero tetramer : IID00816Complex
       Region 6fel E 508-513 order
       Region 6fel F 508-513 order
       Region 6fel G 508-514 order
       Region 6fel H 508-513 order
SeqProS predicted 508-514 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00301Complex
       Region 6y8a P 508-514 order
SeqProS predicted 508-514 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero octamer : IID00061Complex
       Region 6ef5 Q 508-514 order
       Region 6ef5 S 508-514 order
Seqphosphorylation
    522-522 Phosphoserine
    479-479 Phosphoserine
    100-100 Phosphoserine
    114-114 Phosphoserine
    129-129 Phosphoserine
    133-133 Phosphoserine
    137-137 Phosphoserine
    495-495 Phosphoserine
    511-511 Phosphoserine
    572-572 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-143,199-227,485-491,496-588
Order 144-198,228-484,492-495
ProS 1-8,18-22,50-64,74-79,92-102,118-125,138-143,199-211,485-491,496-504,557-569,580-588
AlphaFold
Disorder 1-143,155-158,175-176,206-227,363-363,463-484,495-588
Order 144-154,159-174,177-205,228-362,364-462,485-494
Pfam Hmmer
PF00069 165-446 4.3e-81
SEG 21-30 ,124-144 ,206-222 ,464-472 ,534-552
Function
Function in SwissProt
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
Biological Process
See also
Diagram with PDB data
PRKAA2/PRKAB1/PRKAG1Structure of full length human AMPK in complex with a small molecule activator, a benzimidazole derivative (991)
Camk1/CALM1Solution structure of Ca2+/calmodulin complexed with a peptide representing the calmodulin-binding domain of calmodulin kinase I