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IID00868
 UniprotQ99816
ProteinTumor susceptibility gene 101 protein
GeneTSG101
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
390
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-145 Hetero dimer : P0CG48
 Evidence X-RAY 1s1q A Reference
       Region 1s1q A 1-2 disorder
       Region 1s1q A 3-143 order
       Region 1s1q A 144-145 disorder
 Evidence X-RAY 1s1q C Reference
       Region 1s1q C 1-3 disorder
       Region 1s1q C 4-142 order
       Region 1s1q C 143-145 disorder
Seq 1-145 Hetero trimer :
 Evidence NMR 6ud0 C Reference
       Region 6ud0 C 1-2 disorder
       Region 6ud0 C 3-143 order
       Region 6ud0 C 144-145 disorder
Seq 1-145 Monomer :
 Evidence NMR 1kpp A Reference
       Region 1kpp A 1-1 disorder
       Region 1kpp A 2-145 order
       Region 1kpp A 2-2 high_rmsd
       Region 1kpp A 120-120 high_rmsd
       Region 1kpp A 144-145 high_rmsd
 Evidence NMR 1kpq A Reference
       Region 1kpq A 1-1 disorder
       Region 1kpq A 2-145 order
       Region 1kpq A 2-2 high_rmsd
       Region 1kpq A 144-145 high_rmsd
 Evidence X-RAY 2f0r A Reference
       Region 2f0r A 1-2 disorder
       Region 2f0r A 3-145 order
 Evidence X-RAY 2f0r B Reference
       Region 2f0r B 1-2 disorder
       Region 2f0r B 3-145 order
 Evidence X-RAY 3obs A Reference
       Region 3obs A 2-42 order
       Region 3obs A 46-143 order
       Region 3obs A 144-145 disorder
 Evidence X-RAY 4yc1 A Reference
       Region 4yc1 A 1-145 order
 Evidence X-RAY 4yc1 B Reference
       Region 4yc1 B 1-145 order
 Evidence X-RAY 4yc1 C Reference
       Region 4yc1 C 1-2 disorder
       Region 4yc1 C 3-145 order
 Evidence NMR 5vkg A Reference
       Region 5vkg A 2-145 order
Seq 1-145 Homo dodecamer :
 Evidence X-RAY 7zlx A Reference
       Region 7zlx A 1-1 disorder
       Region 7zlx A 2-145 order
 Evidence X-RAY 7zlx B Reference
       Region 7zlx B 1-145 order
 Evidence X-RAY 7zlx C Reference
       Region 7zlx C 1-145 order
 Evidence X-RAY 7zlx D Reference
       Region 7zlx D 1-145 order
 Evidence X-RAY 7zlx E Reference
       Region 7zlx E 1-145 order
 Evidence X-RAY 7zlx F Reference
       Region 7zlx F 1-145 order
 Evidence X-RAY 7zlx G Reference
       Region 7zlx G 1-5 disorder
       Region 7zlx G 6-145 order
 Evidence X-RAY 7zlx H Reference
       Region 7zlx H 1-3 disorder
       Region 7zlx H 4-44 order
       Region 7zlx H 45-48 disorder
       Region 7zlx H 49-145 order
 Evidence X-RAY 7zlx I Reference
       Region 7zlx I 1-145 order
 Evidence X-RAY 7zlx J Reference
       Region 7zlx J 1-42 order
       Region 7zlx J 43-47 disorder
       Region 7zlx J 48-145 order
 Evidence X-RAY 7zlx K Reference
       Region 7zlx K 1-5 disorder
       Region 7zlx K 6-44 order
       Region 7zlx K 45-48 disorder
       Region 7zlx K 49-145 order
 Evidence X-RAY 7zlx L Reference
       Region 7zlx L 1-5 disorder
       Region 7zlx L 6-145 order
Seq 1-145 Hetero dimer : Q9IF21
 Evidence NMR 1m4p A Reference
       Region 1m4p A 1-1 disorder
       Region 1m4p A 2-145 order
       Region 1m4p A 2-2 high_rmsd
 Evidence NMR 1m4q A Reference
       Region 1m4q A 1-1 disorder
       Region 1m4q A 2-145 order
Seq 1-145 Hetero dimer : Q05128
 Evidence X-RAY 4eje A Reference
       Region 4eje A 1-2 disorder
       Region 4eje A 3-145 order
 Evidence X-RAY 4eje B Reference
       Region 4eje B 1-2 disorder
       Region 4eje B 3-144 order
       Region 4eje B 145-145 disorder
Seq 1-145 Hetero dimer : Q9YLR0
 Evidence X-RAY 7nlc A Reference
       Region 7nlc A 1-1 disorder
       Region 7nlc A 2-145 order
Seq 2-42,46-145 Hetero dimer : Q72497
 Evidence X-RAY 3obu A Reference
       Region 3obu A 2-42 order
       Region 3obu A 46-145 order
 Evidence X-RAY 3obx A Reference
       Region 3obx A 2-2 disorder
       Region 3obx A 3-42 order
       Region 3obx A 46-145 order
Seq 2-42,47-145 Hetero dimer : Q9YP46
 Evidence X-RAY 3p9g A Reference
       Region 3p9g A 2-42 order
       Region 3p9g A 47-145 order
 Evidence X-RAY 3p9h A Reference
       Region 3p9h A 2-42 order
       Region 3p9h A 47-145 order
Seq 2-42,46-145 Hetero dimer : IID00751Complex
 Evidence X-RAY 3obq A Reference
       Region 3obq A 2-42 order
       Region 3obq A 46-145 order
Seq 4-145 Hetero dimer : P14078
 Evidence X-RAY 4zny A Reference
       Region 4zny A 4-145 order
Seq 229-304 Homo tetramer :
 Evidence X-RAY 3iv1 A Reference
       Region 3iv1 A 229-304 order
 Evidence X-RAY 3iv1 B Reference
       Region 3iv1 B 229-304 order
 Evidence X-RAY 3iv1 C Reference
       Region 3iv1 C 229-304 order
 Evidence X-RAY 3iv1 D Reference
       Region 3iv1 D 229-304 order
 Evidence X-RAY 3iv1 E Reference
       Region 3iv1 E 229-304 order
 Evidence X-RAY 3iv1 F Reference
       Region 3iv1 F 229-304 order
 Evidence X-RAY 3iv1 G Reference
       Region 3iv1 G 229-304 order
 Evidence X-RAY 3iv1 H Reference
       Region 3iv1 H 229-304 order
Seq 308-388 Hetero 24mer : IID00861Complex,IID00878Complex,IID00890Complex
 Evidence X-RAY 6vme B Reference
       Region 6vme B 308-312 disorder
       Region 6vme B 313-388 order
 Evidence X-RAY 6vme F Reference
       Region 6vme F 308-311 disorder
       Region 6vme F 312-388 order
 Evidence X-RAY 6vme G Reference
       Region 6vme G 308-313 disorder
       Region 6vme G 314-388 order
 Evidence X-RAY 6vme H Reference
       Region 6vme H 308-311 disorder
       Region 6vme H 312-387 order
       Region 6vme H 388-388 disorder
 Evidence X-RAY 6vme I Reference
       Region 6vme I 308-312 disorder
       Region 6vme I 313-387 order
       Region 6vme I 388-388 disorder
 Evidence X-RAY 6vme J Reference
       Region 6vme J 308-311 disorder
       Region 6vme J 312-387 order
       Region 6vme J 388-388 disorder
Seqphosphorylation
    220-220 Phosphothreonine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-1,156-225,230-234
Order 2-155,226-229,235-390
ProS 156-156,165-183,203-208,230-234
AlphaFold
Disorder 1-2,146-222,309-313,315-315,317-317,388-390
Order 3-145,223-308,314-314,316-316,318-387
Pfam Hmmer
PF05743 21-141 8.9e-73
SEG 162-197
Function
Function in SwissProt
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426).
Biological Process
Diagram with PDB data
TSG101/HGSCrystal Structure of the Tsg101 UEV domain in complex with a human HRS PSAP peptide
See also
Diagram with PDB data
VPS36/SNF8/VPS25/VPS25Integrated structural and functional model of the human ESCRT-II complex
CHMP6/VPS25Crystal structure of the human VPS25-VPS20 subcomplex