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IID00869
UniprotQ9BRG1
ProteinVacuolar protein-sorting-associated protein 25
GeneVPS25
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
176
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-102 Hetero tetramer : IID00218Complex,IID00864Complex
 Evidence X-RAY 2zme D Reference
       Region 2zme D 1-4 disorder
       Region 2zme D 5-101 order
       Region 2zme D 102-102 disorder
 Evidence X-RAY 2zme C Reference
       Region 2zme C 1-3 disorder
       Region 2zme C 4-102 order
Seq 1-176 Hetero trimer : IID00218Complex,IID00864Complex
 Evidence X-RAY 3cuq D Reference
       Region 3cuq D 1-4 disorder
       Region 3cuq D 5-101 order
       Region 3cuq D 102-176 disorder
 Evidence X-RAY 3cuq C Reference
       Region 3cuq C 1-3 disorder
       Region 3cuq C 4-176 order
Seq 102-176 Hetero dimer : IID00862Complex
 Evidence X-RAY 3htu A Reference
       Region 3htu A 102-176 order
 Evidence X-RAY 3htu C Reference
       Region 3htu C 102-176 order
 Evidence X-RAY 3htu E Reference
       Region 3htu E 102-176 order
 Evidence X-RAY 3htu G Reference
       Region 3htu G 102-176 order
 
Prediction
NeProc
Disorder 1-1
Order 2-176
AlphaFold
Disorder 1-3
Order 4-176
Pfam Hmmer
PF05871 5-176 1.9e-114
SEG 147-158
Function
Function in SwissProt
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses.
Biological Process
See also
Diagram with PDB data
VPS36/SNF8/VPS25/VPS25Integrated structural and functional model of the human ESCRT-II complex
CHMP6/VPS25Crystal structure of the human VPS25-VPS20 subcomplex