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IID00870
 UniprotQ9BTT0
ProteinAcidic leucine-rich nuclear phosphoprotein 32 family member E
GeneANP32E
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
268
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 185-232 Hetero decamer : IID00019Complex,Q16778
 Evidence X-RAY 4nft F Reference
       Region 4nft F 185-213 disorder
       Region 4nft F 214-224 order
       Region 4nft F 225-232 disorder
 Evidence X-RAY 4nft E Reference
       Region 4nft E 185-213 disorder
       Region 4nft E 214-224 order
       Region 4nft E 225-232 disorder
Seq 215-240 Hetero trimer : IID00019Complex,P06899
 Evidence X-RAY 4cay C Reference
       Region 4cay C 215-237 order
       Region 4cay C 238-240 disorder
SeqProS predicted 214-224 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero decamer : IID00019Complex,Q16778
       Region 4nft E 214-224 order
       Region 4nft F 214-224 order
SeqProS predicted 215-237 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero trimer : IID00019Complex,P06899
       Region 4cay C 215-237 order
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 150-268
Order 1-149
ProS 150-157,216-222,249-263
AlphaFold
Disorder 158-268
Order 1-157
SEG 151-215 ,224-268
Function
Function in SwissProt
Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis.
Biological Process
Diagram with PDB data
ANP32E/H2AZ1/H2BC11Crystal structure of a human Anp32e-H2A.Z-H2B complex