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IID00874
 UniprotQ9GZV5
ProteinWW domain-containing transcription regulator protein 1
GeneWWTR1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
400
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 86-95 Hetero tetramer : IID00301Complex
 Evidence X-RAY 5n5t P Reference
       Region 5n5t P 87-94 order
 Evidence X-RAY 5n5w P Reference
       Region 5n5w P 86-95 order
 Evidence X-RAY 5n75 P Reference
       Region 5n75 P 86-95 order
Seq 86-98 Hetero dimer : IID00301Complex
 Evidence X-RAY 5n5r P Reference
       Region 5n5r P 87-95 order
 Evidence X-RAY 6rhc P Reference
       Region 6rhc P 86-98 order
 Evidence X-RAY 6rjl P Reference
       Region 6rjl P 86-95 order
       Region 6rjl P 96-98 disorder
 Evidence X-RAY 6rjq P Reference
       Region 6rjq P 86-95 order
       Region 6rjq P 96-98 disorder
 Evidence X-RAY 6rp6 P Reference
       Region 6rp6 P 86-95 order
       Region 6rp6 P 96-98 disorder
 Evidence X-RAY 6slw P Reference
       Region 6slw P 86-95 order
       Region 6slw P 96-98 disorder
 Evidence X-RAY 6slx P Reference
       Region 6slx P 86-95 order
       Region 6slx P 96-98 disorder
SeqProS predicted 86-95 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero dimer : IID00301Complex
       Region 6rhc P 86-98 order
       Region 6rp6 P 86-95 order
       Region 6slw P 86-95 order
       Region 5n5r P 87-95 order
       Region 6rjl P 86-95 order
       Region 6rjq P 86-95 order
       Region 6slx P 86-95 order
SeqProS predicted 86-95 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero tetramer : IID00301Complex
       Region 5n75 P 86-95 order
       Region 5n5t P 87-94 order
       Region 5n5w P 86-95 order
Seqphosphorylation
    89-89 Phosphoserine; by LATS2
    105-105 Phosphoserine
    295-295 Phosphoserine
    311-311 Phosphoserine; by LATS2
    62-62 Phosphoserine
 
Prediction
NeProc
Disorder 1-14,21-31,40-123,159-224,265-400
Order 15-20,32-39,124-158,225-264
ProS 21-31,40-56,120-123,188-193,202-205,218-223,299-307,318-334,356-372,380-400
AlphaFold
Disorder 1-5,40-41,58-123,159-225,262-262,264-400
Order 6-39,42-57,124-158,226-261,263-263
Pfam Hmmer
PF00397 126-155 6.7e-12
SEG 3-13 ,228-258
Function
Function in SwissProt
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:18227151). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18227151). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (PubMed:19010321). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:18568018). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (PubMed:18568018). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (PubMed:18227151, PubMed:18568018).
Biological Process
Diagram with PDB data
WWTR1/SFN14-3-3 sigma in complex with TAZ pS89 peptide
Diagram without PDB data
WWTR1Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression