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IID00875
 UniprotQ9H3D4
ProteinTumor protein 63
GeneTP63
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
680
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 47-73 Hetero dimer : IID00070Complex
 Evidence NMR 6fgn A Reference
       Region 6fgn A 47-73 order
       Region 6fgn A 72-73 high_rmsd
Seq 153-388 Monomer :
 Evidence NMR 2rmn A Reference
       Region 2rmn A 153-373 order
       Region 2rmn A 153-159 high_rmsd
       Region 2rmn A 366-384 high_rmsd
       Region 2rmn A 378-388 order
Seq 162-363 Hetero dimer :
 Evidence X-RAY 7z7e A Reference
       Region 7z7e A 162-162 disorder
       Region 7z7e A 163-185 order
       Region 7z7e A 186-189 disorder
       Region 7z7e A 190-359 order
       Region 7z7e A 360-363 disorder
Seq 162-363 Hetero tetramer :
 Evidence X-RAY 7z71 C Reference
       Region 7z71 C 162-163 disorder
       Region 7z71 C 164-182 order
       Region 7z71 C 183-189 disorder
       Region 7z71 C 190-359 order
       Region 7z71 C 360-363 disorder
 Evidence X-RAY 7z71 A Reference
       Region 7z71 A 162-163 disorder
       Region 7z71 A 164-359 order
       Region 7z71 A 360-363 disorder
Seq 166-362 Homo tetramer :
 Evidence X-RAY 3qym D Reference
       Region 3qym D 166-359 order
       Region 3qym D 360-362 disorder
 Evidence X-RAY 3qym C Reference
       Region 3qym C 166-359 order
       Region 3qym C 360-362 disorder
 Evidence X-RAY 3qym B Reference
       Region 3qym B 166-185 order
       Region 3qym B 186-188 disorder
       Region 3qym B 189-359 order
       Region 3qym B 360-362 disorder
 Evidence X-RAY 3qym A Reference
       Region 3qym A 166-182 order
       Region 3qym A 183-185 disorder
       Region 3qym A 186-359 order
       Region 3qym A 360-362 disorder
 Evidence X-RAY 3qym H Reference
       Region 3qym H 166-183 order
       Region 3qym H 184-188 disorder
       Region 3qym H 189-359 order
       Region 3qym H 360-362 disorder
 Evidence X-RAY 3qym G Reference
       Region 3qym G 166-166 disorder
       Region 3qym G 167-184 order
       Region 3qym G 185-187 disorder
       Region 3qym G 188-359 order
       Region 3qym G 360-362 disorder
 Evidence X-RAY 3qym F Reference
       Region 3qym F 166-359 order
       Region 3qym F 360-362 disorder
 Evidence X-RAY 3qym E Reference
       Region 3qym E 166-360 order
       Region 3qym E 361-362 disorder
Seq 166-362 Homo tetramer :
 Evidence X-RAY 3qyn D Reference
       Region 3qyn D 166-182 order
       Region 3qyn D 183-189 disorder
       Region 3qyn D 190-359 order
       Region 3qyn D 360-362 disorder
 Evidence X-RAY 3qyn C Reference
       Region 3qyn C 166-359 order
       Region 3qyn C 360-362 disorder
 Evidence X-RAY 3qyn B Reference
       Region 3qyn B 166-182 order
       Region 3qyn B 183-188 disorder
       Region 3qyn B 189-361 order
       Region 3qyn B 362-362 disorder
 Evidence X-RAY 3qyn A Reference
       Region 3qyn A 166-359 order
       Region 3qyn A 360-362 disorder
 Evidence X-RAY 3us0 D Reference
       Region 3us0 D 166-182 order
       Region 3us0 D 183-189 disorder
       Region 3us0 D 190-361 order
       Region 3us0 D 362-362 disorder
 Evidence X-RAY 3us0 C Reference
       Region 3us0 C 166-359 order
       Region 3us0 C 360-362 disorder
 Evidence X-RAY 3us0 B Reference
       Region 3us0 B 166-182 order
       Region 3us0 B 183-188 disorder
       Region 3us0 B 189-361 order
       Region 3us0 B 362-362 disorder
 Evidence X-RAY 3us0 A Reference
       Region 3us0 A 166-359 order
       Region 3us0 A 360-362 disorder
Seq 166-362 Homo tetramer :
 Evidence X-RAY 3qym C Reference
       Region 3qym C 166-359 order
       Region 3qym C 360-362 disorder
 Evidence X-RAY 3qym D Reference
       Region 3qym D 166-359 order
       Region 3qym D 360-362 disorder
 Evidence X-RAY 3qym E Reference
       Region 3qym E 166-360 order
       Region 3qym E 361-362 disorder
 Evidence X-RAY 3qym F Reference
       Region 3qym F 166-359 order
       Region 3qym F 360-362 disorder
 Evidence X-RAY 3us1 A Reference
       Region 3us1 A 166-186 order
       Region 3us1 A 187-187 disorder
       Region 3us1 A 188-358 order
       Region 3us1 A 359-362 disorder
 Evidence X-RAY 3us1 D Reference
       Region 3us1 D 166-169 disorder
       Region 3us1 D 170-182 order
       Region 3us1 D 183-190 disorder
       Region 3us1 D 191-359 order
       Region 3us1 D 360-362 disorder
 Evidence X-RAY 3us2 A Reference
       Region 3us2 A 166-186 order
       Region 3us2 A 187-187 disorder
       Region 3us2 A 188-358 order
       Region 3us2 A 359-362 disorder
 Evidence X-RAY 3us2 B Reference
       Region 3us2 B 166-169 disorder
       Region 3us2 B 170-182 order
       Region 3us2 B 183-190 disorder
       Region 3us2 B 191-359 order
       Region 3us2 B 360-362 disorder
 Evidence X-RAY 3us2 C Reference
       Region 3us2 C 166-186 order
       Region 3us2 C 187-187 disorder
       Region 3us2 C 188-358 order
       Region 3us2 C 359-362 disorder
 Evidence X-RAY 3us2 D Reference
       Region 3us2 D 166-169 disorder
       Region 3us2 D 170-182 order
       Region 3us2 D 183-190 disorder
       Region 3us2 D 191-359 order
       Region 3us2 D 360-362 disorder
 Evidence X-RAY 3us2 G Reference
       Region 3us2 G 166-186 order
       Region 3us2 G 187-187 disorder
       Region 3us2 G 188-358 order
       Region 3us2 G 359-362 disorder
 Evidence X-RAY 3us2 H Reference
       Region 3us2 H 166-169 disorder
       Region 3us2 H 170-182 order
       Region 3us2 H 183-190 disorder
       Region 3us2 H 191-359 order
       Region 3us2 H 360-362 disorder
 Evidence X-RAY 3us2 I Reference
       Region 3us2 I 166-186 order
       Region 3us2 I 187-187 disorder
       Region 3us2 I 188-358 order
       Region 3us2 I 359-362 disorder
 Evidence X-RAY 3us2 J Reference
       Region 3us2 J 166-169 disorder
       Region 3us2 J 170-182 order
       Region 3us2 J 183-190 disorder
       Region 3us2 J 191-359 order
       Region 3us2 J 360-362 disorder
Seq 397-455 Hetero tetramer : IID00753Complex
 Evidence NMR 2nb1 C Reference
       Region 2nb1 C 397-455 order
       Region 2nb1 C 433-455 high_rmsd
 Evidence NMR 2nb1 A Reference
       Region 2nb1 A 397-455 order
       Region 2nb1 A 433-455 high_rmsd
Seq 397-455 Hetero hexamer :
 Evidence X-RAY 7z73 D Reference
       Region 7z73 D 397-398 disorder
       Region 7z73 D 399-441 order
       Region 7z73 D 442-455 disorder
 Evidence X-RAY 7z73 C Reference
       Region 7z73 C 397-397 disorder
       Region 7z73 C 398-441 order
       Region 7z73 C 442-455 disorder
 Evidence X-RAY 7z73 B Reference
       Region 7z73 B 397-398 disorder
       Region 7z73 B 399-446 order
       Region 7z73 B 447-455 disorder
 Evidence X-RAY 7z73 A Reference
       Region 7z73 A 397-397 disorder
       Region 7z73 A 398-445 order
       Region 7z73 A 446-455 disorder
Seq 397-455 Homo tetramer :
 Evidence X-RAY 4a9z A Reference
       Region 4a9z A 397-443 order
       Region 4a9z A 444-455 disorder
 Evidence X-RAY 4a9z B Reference
       Region 4a9z B 397-441 order
       Region 4a9z B 442-455 disorder
 Evidence X-RAY 4a9z C Reference
       Region 4a9z C 397-454 order
       Region 4a9z C 455-455 disorder
 Evidence X-RAY 4a9z D Reference
       Region 4a9z D 397-440 order
       Region 4a9z D 441-455 disorder
Seq 397-455 Hetero trimer : IID00753Complex
 Evidence X-RAY 8p9c A Reference
       Region 8p9c A 397-397 disorder
       Region 8p9c A 398-451 order
       Region 8p9c A 452-455 disorder
Seq 397-455 Hetero hexamer : IID00753Complex
 Evidence X-RAY 8p9d C Reference
       Region 8p9d C 397-397 disorder
       Region 8p9d C 398-443 order
       Region 8p9d C 444-455 disorder
 Evidence X-RAY 8p9d A Reference
       Region 8p9d A 397-397 disorder
       Region 8p9d A 398-443 order
       Region 8p9d A 444-455 disorder
Seq 397-455 Hetero trimer : IID00753Complex
 Evidence X-RAY 8p9e A Reference
       Region 8p9e A 397-452 order
       Region 8p9e A 453-455 disorder
Seq 398-427 Homo tetramer :
 Evidence X-RAY 3zy0 D Reference
       Region 3zy0 D 398-399 disorder
       Region 3zy0 D 400-425 order
       Region 3zy0 D 426-427 disorder
 Evidence X-RAY 3zy0 C Reference
       Region 3zy0 C 398-399 disorder
       Region 3zy0 C 400-427 order
 Evidence X-RAY 3zy0 B Reference
       Region 3zy0 B 398-399 disorder
       Region 3zy0 B 400-426 order
       Region 3zy0 B 427-427 disorder
 Evidence X-RAY 3zy0 A Reference
       Region 3zy0 A 398-398 disorder
       Region 3zy0 A 399-427 order
Seq 398-441 Homo tetramer :
 Evidence X-RAY 3zy1 A Reference
       Region 3zy1 A 398-437 order
       Region 3zy1 A 438-441 disorder
Seq 540-622 Monomer :
 Evidence NMR 1rg6 A Reference
       Region 1rg6 A 540-543 disorder
       Region 1rg6 A 544-610 order
       Region 1rg6 A 544-545 high_rmsd
       Region 1rg6 A 610-610 high_rmsd
       Region 1rg6 A 611-614 disorder
 Evidence NMR 2y9t A Reference
       Region 2y9t A 543-622 order
       Region 2y9t A 543-544 high_rmsd
       Region 2y9t A 610-622 high_rmsd
 Evidence X-RAY 2y9u A Reference
       Region 2y9u A 545-611 order
Seq 545-611 Hetero dimer :
 Evidence X-RAY 7z72 A Reference
       Region 7z72 A 545-609 order
       Region 7z72 A 610-611 disorder
Seq 618-630 Hetero trimer : P48730
 Evidence X-RAY 6ru6 C Reference
       Region 6ru6 C 618-625 order
       Region 6ru6 C 626-630 disorder
Seq 618-633 Hetero tetramer : P48730
 Evidence X-RAY 6ru7 D Reference
       Region 6ru7 D 618-619 disorder
       Region 6ru7 D 620-632 order
       Region 6ru7 D 633-633 disorder
 Evidence X-RAY 6ru7 C Reference
       Region 6ru7 C 618-632 order
       Region 6ru7 C 633-633 disorder
Seq 621-632 Hetero octamer : P48730
 Evidence X-RAY 6ru8 H Reference
       Region 6ru8 H 621-629 order
       Region 6ru8 H 630-632 disorder
 Evidence X-RAY 6ru8 G Reference
       Region 6ru8 G 621-629 order
       Region 6ru8 G 630-632 disorder
 Evidence X-RAY 6ru8 F Reference
       Region 6ru8 F 621-632 order
 Evidence X-RAY 6ru8 E Reference
       Region 6ru8 E 621-630 order
       Region 6ru8 E 631-632 disorder
SeqProS possible 47-73 The TAD of the p53 family, which includes p63, is largely disordered in the free state (PMID=25591003). Hetero dimer : IID00070Complex
       Region 6fgn A 47-73 order
SeqProS predicted 618-632 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). This phosphorylation activation domain is related to dimer-tetramer transition (PMID=35314772). Hetero trimer : P48730
       Region 6ru6 C 618-625 order
SeqProS predicted 618-632 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). This phosphorylation activation domain is related to dimer-tetramer transition (PMID=35314772). Hetero tetramer : P48730
       Region 6ru7 C 618-632 order
       Region 6ru7 D 620-632 order
SeqProS predicted 618-632 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). This phosphorylation activation domain is related to dimer-tetramer transition (PMID=35314772). Hetero octamer : P48730
       Region 6ru8 E 621-630 order
       Region 6ru8 F 621-632 order
       Region 6ru8 G 621-629 order
       Region 6ru8 H 621-629 order
 
Prediction
NeProc
Disorder 1-5,26-52,58-163,355-397,433-542,607-634,672-680
Order 6-25,53-57,164-354,398-432,543-606,635-671
ProS 1-5,26-37,48-52,58-100,106-137,143-147,355-358,433-437,444-448,516-519,607-611,672-680
AlphaFold
Disorder 1-162,364-397,447-545,608-645,647-647,649-649,651-680
Order 163-363,398-446,546-607,646-646,648-648,650-650
Pfam Hmmer
PF00870 163-359 1.7e-148
PF07710 391-432 2.9e-12
PF07647 541-607 3e-13
SEG 437-450 ,621-631
Function
Function in SwissProt
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.