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IID00878
 UniprotQ9H9H4
ProteinVacuolar protein sorting-associated protein 37B
GeneVPS37B
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
285
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 97-167 Hetero 24mer : IID00861Complex,IID00868Complex,IID00890Complex
 Evidence X-RAY 6vme C Reference
       Region 6vme C 97-98 disorder
       Region 6vme C 99-165 order
       Region 6vme C 166-167 disorder
 Evidence X-RAY 6vme K Reference
       Region 6vme K 97-101 disorder
       Region 6vme K 102-166 order
       Region 6vme K 167-167 disorder
 Evidence X-RAY 6vme L Reference
       Region 6vme L 97-101 disorder
       Region 6vme L 102-166 order
       Region 6vme L 167-167 disorder
 Evidence X-RAY 6vme M Reference
       Region 6vme M 97-100 disorder
       Region 6vme M 101-165 order
       Region 6vme M 166-167 disorder
 Evidence X-RAY 6vme N Reference
       Region 6vme N 97-98 disorder
       Region 6vme N 99-165 order
       Region 6vme N 166-167 disorder
 Evidence X-RAY 6vme O Reference
       Region 6vme O 97-102 disorder
       Region 6vme O 103-164 order
       Region 6vme O 165-167 disorder
 
Prediction
NeProc
Disorder 1-11,116-120,156-285
Order 12-115,121-155
ProS 7-11,116-120,156-164,280-285
AlphaFold
Disorder 1-8,100-100,166-207,214-263,266-270,272-275,278-281,283-285
Order 9-99,101-165,208-213,264-265,271-271,276-277,282-282
Pfam Hmmer
PF07200 10-159 1.4e-66
SEG 97-115 ,169-196 ,199-216 ,234-245 ,262-280
Function
Function in SwissProt
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Biological Process
See also
Diagram with PDB data
VPS36/SNF8/VPS25/VPS25Integrated structural and functional model of the human ESCRT-II complex
CHMP6/VPS25Crystal structure of the human VPS25-VPS20 subcomplex
TSG101/HGSCrystal Structure of the Tsg101 UEV domain in complex with a human HRS PSAP peptide