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IID00883
 UniprotQ9NQU5
ProteinSerine/threonine-protein kinase PAK 6
GenePAK6
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
681
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 11-45 Hetero dimer : IID00308Complex
 Evidence X-RAY 2odb B Reference
       Region 2odb B 11-45 order
Seq 94-104 Hetero dimer : IID00301Complex
 Evidence X-RAY 6qdr B Reference
       Region 6qdr B 94-95 disorder
       Region 6qdr B 96-101 order
       Region 6qdr B 102-104 disorder
 Evidence X-RAY 6qds B Reference
       Region 6qds B 94-96 disorder
       Region 6qds B 97-101 order
       Region 6qds B 102-104 disorder
Seq 383-681 Monomer :
 Evidence X-RAY 2c30 A Reference
       Region 2c30 A 383-384 disorder
       Region 2c30 A 385-674 order
       Region 2c30 A 675-681 disorder
 Evidence X-RAY 4ks7 A Reference
       Region 4ks7 A 385-385 disorder
       Region 4ks7 A 386-672 order
       Region 4ks7 A 673-674 disorder
 Evidence X-RAY 4ks8 A Reference
       Region 4ks8 A 385-671 order
       Region 4ks8 A 672-674 disorder
SeqProS predicted 96-101 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00301Complex
       Region 6qds B 97-101 order
       Region 6qdr B 96-101 order
Seqphosphorylation
    560-560 Phosphoserine; by autocatalysis
 
Prediction
NeProc
Disorder 1-10,72-386,678-681
Order 11-71,387-677
ProS 72-99,207-212,220-252,678-681
AlphaFold
Disorder 1-7,18-19,45-383,677-681
Order 8-17,20-44,384-676
Pfam Hmmer
PF00786 11-67 1.1e-19
PF00069 407-658 2e-82
SEG 201-212 ,267-290
Function
Function in SwissProt
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.