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IID00886
UniprotQ9NYB0
ProteinTelomeric repeat-binding factor 2-interacting protein 1
GeneTERF2IP
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
399
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-114 Monomer :
 Evidence NMR 7oz0 A Reference
       Region 7oz0 A 1-114 order
       Region 7oz0 A 1-13 high_rmsd
       Region 7oz0 A 70-72 high_rmsd
       Region 7oz0 A 104-114 high_rmsd
Seq 89-106 Hetero tetramer : IID00837Complex
 Evidence X-RAY 4rqi F Reference
       Region 4rqi F 89-92 order
       Region 4rqi F 93-93 disorder
       Region 4rqi F 94-103 order
       Region 4rqi F 104-106 disorder
 Evidence X-RAY 4rqi E Reference
       Region 4rqi E 89-90 disorder
       Region 4rqi E 91-105 order
       Region 4rqi E 106-106 disorder
Seq 89-106 Hetero tetramer : IID00837Complex
 Evidence X-RAY 4rqi H Reference
       Region 4rqi H 89-91 disorder
       Region 4rqi H 92-106 order
 Evidence X-RAY 4rqi G Reference
       Region 4rqi G 89-94 disorder
       Region 4rqi G 95-106 order
Seq 132-190 Monomer :
 Evidence NMR 1fex A Reference
       Region 1fex A 132-190 order
       Region 1fex A 132-133 high_rmsd
       Region 1fex A 190-190 high_rmsd
Seq 303-399 Hetero dimer : IID00837Complex
 Evidence X-RAY 3k6g A Reference
       Region 3k6g A 303-305 disorder
       Region 3k6g A 306-398 order
       Region 3k6g A 399-399 disorder
 Evidence X-RAY 3k6g B Reference
       Region 3k6g B 303-306 disorder
       Region 3k6g B 307-398 order
       Region 3k6g B 399-399 disorder
 Evidence X-RAY 3k6g C Reference
       Region 3k6g C 303-305 disorder
       Region 3k6g C 306-398 order
       Region 3k6g C 399-399 disorder
Seqphosphorylation
    206-206 Phosphoserine
    203-203 Phosphoserine
    156-156 Phosphoserine
    154-154 Phosphoserine
    43-43 Phosphoserine
    36-36 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-14,109-130,203-239,268-322
Order 15-108,131-202,240-267,323-399
ProS 4-14,109-120,209-215,222-239,284-288,298-302,311-322
AlphaFold
Disorder 1-14,70-75,102-133,154-156,193-193,195-250,254-305,399-399
Order 15-69,76-101,134-153,157-192,194-194,251-253,306-398
SEG 112-127 ,281-311 ,366-376
Function
Function in SwissProt
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.