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IID00889
 UniprotQ9UIK4
ProteinDeath-associated protein kinase 2
GeneDAPK2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
370
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 11-330 Homo dimer :
 Evidence X-RAY 1zws A Reference
       Region 1zws A 11-11 disorder
       Region 1zws A 12-289 order
       Region 1zws A 290-297 disorder
 Evidence X-RAY 1zws B Reference
       Region 1zws B 11-11 disorder
       Region 1zws B 12-289 order
       Region 1zws B 290-297 disorder
 Evidence X-RAY 1zws C Reference
       Region 1zws C 11-11 disorder
       Region 1zws C 12-289 order
       Region 1zws C 290-297 disorder
 Evidence X-RAY 1zws D Reference
       Region 1zws D 11-11 disorder
       Region 1zws D 12-289 order
       Region 1zws D 290-297 disorder
 Evidence X-RAY 1zws E Reference
       Region 1zws E 11-11 disorder
       Region 1zws E 12-289 order
       Region 1zws E 290-297 disorder
 Evidence X-RAY 1zws F Reference
       Region 1zws F 11-11 disorder
       Region 1zws F 12-289 order
       Region 1zws F 290-297 disorder
 Evidence X-RAY 1zws G Reference
       Region 1zws G 11-11 disorder
       Region 1zws G 12-289 order
       Region 1zws G 290-297 disorder
 Evidence X-RAY 1zws H Reference
       Region 1zws H 11-11 disorder
       Region 1zws H 12-289 order
       Region 1zws H 290-297 disorder
 Evidence X-RAY 2a27 A Reference
       Region 2a27 A 11-11 disorder
       Region 2a27 A 12-315 order
       Region 2a27 A 316-330 disorder
 Evidence X-RAY 2a27 E Reference
       Region 2a27 E 11-11 disorder
       Region 2a27 E 12-314 order
       Region 2a27 E 315-330 disorder
 Evidence X-RAY 2a27 B Reference
       Region 2a27 B 11-11 disorder
       Region 2a27 B 12-314 order
       Region 2a27 B 315-330 disorder
 Evidence X-RAY 2a27 C Reference
       Region 2a27 C 11-11 disorder
       Region 2a27 C 12-314 order
       Region 2a27 C 315-330 disorder
 Evidence X-RAY 2a27 D Reference
       Region 2a27 D 11-11 disorder
       Region 2a27 D 12-315 order
       Region 2a27 D 316-330 disorder
 Evidence X-RAY 2a27 G Reference
       Region 2a27 G 11-11 disorder
       Region 2a27 G 12-314 order
       Region 2a27 G 315-330 disorder
 Evidence X-RAY 2a27 F Reference
       Region 2a27 F 11-11 disorder
       Region 2a27 F 12-314 order
       Region 2a27 F 315-330 disorder
 Evidence X-RAY 2a27 H Reference
       Region 2a27 H 11-11 disorder
       Region 2a27 H 12-315 order
       Region 2a27 H 316-330 disorder
 Evidence X-RAY 2a2a A Reference
       Region 2a2a A 11-314 order
       Region 2a2a A 315-330 disorder
 Evidence X-RAY 2a2a B Reference
       Region 2a2a B 11-11 disorder
       Region 2a2a B 12-314 order
       Region 2a2a B 315-330 disorder
 Evidence X-RAY 2a2a C Reference
       Region 2a2a C 11-11 disorder
       Region 2a2a C 12-314 order
       Region 2a2a C 315-330 disorder
 Evidence X-RAY 2a2a D Reference
       Region 2a2a D 11-11 disorder
       Region 2a2a D 12-314 order
       Region 2a2a D 315-330 disorder
Seq 11-330 Monomer :
 Evidence X-RAY 1wmk A Reference
       Region 1wmk A 11-11 disorder
       Region 1wmk A 12-314 order
       Region 1wmk A 315-330 disorder
 Evidence X-RAY 1wmk E Reference
       Region 1wmk E 11-11 disorder
       Region 1wmk E 12-324 order
       Region 1wmk E 325-330 disorder
 Evidence X-RAY 1wmk C Reference
       Region 1wmk C 11-11 disorder
       Region 1wmk C 12-314 order
       Region 1wmk C 315-330 disorder
 Evidence X-RAY 1wmk B Reference
       Region 1wmk B 11-11 disorder
       Region 1wmk B 12-325 order
       Region 1wmk B 326-330 disorder
 Evidence X-RAY 1wmk F Reference
       Region 1wmk F 11-11 disorder
       Region 1wmk F 12-314 order
       Region 1wmk F 315-330 disorder
 Evidence X-RAY 1wmk D Reference
       Region 1wmk D 11-11 disorder
       Region 1wmk D 12-325 order
       Region 1wmk D 326-330 disorder
 Evidence X-RAY 1wmk H Reference
       Region 1wmk H 11-11 disorder
       Region 1wmk H 12-315 order
       Region 1wmk H 316-330 disorder
 Evidence X-RAY 1wmk G Reference
       Region 1wmk G 11-11 disorder
       Region 1wmk G 12-324 order
       Region 1wmk G 325-330 disorder
 Evidence X-RAY 1z9x A Reference
       Region 1z9x A 11-11 disorder
       Region 1z9x A 12-314 order
       Region 1z9x A 315-330 disorder
 Evidence X-RAY 1z9x B Reference
       Region 1z9x B 11-11 disorder
       Region 1z9x B 12-314 order
       Region 1z9x B 315-330 disorder
 Evidence X-RAY 1z9x C Reference
       Region 1z9x C 11-11 disorder
       Region 1z9x C 12-314 order
       Region 1z9x C 315-330 disorder
Seq 11-330 Homo tetramer :
 Evidence X-RAY 2cke D Reference
       Region 2cke D 11-11 disorder
       Region 2cke D 12-311 order
       Region 2cke D 312-330 disorder
 Evidence X-RAY 2cke C Reference
       Region 2cke C 11-11 disorder
       Region 2cke C 12-311 order
       Region 2cke C 312-330 disorder
 Evidence X-RAY 2cke B Reference
       Region 2cke B 11-11 disorder
       Region 2cke B 12-311 order
       Region 2cke B 312-330 disorder
 Evidence X-RAY 2cke A Reference
       Region 2cke A 11-311 order
       Region 2cke A 312-330 disorder
Seq 12-330 Hetero octamer : IID00706Complex
 Evidence X-RAY 6paw F Reference
       Region 6paw F 12-13 disorder
       Region 6paw F 14-327 order
       Region 6paw F 328-330 disorder
 Evidence X-RAY 6paw E Reference
       Region 6paw E 12-13 disorder
       Region 6paw E 14-318 order
       Region 6paw E 319-330 disorder
 Evidence X-RAY 6paw B Reference
       Region 6paw B 12-13 disorder
       Region 6paw B 14-329 order
       Region 6paw B 330-330 disorder
 Evidence X-RAY 6paw A Reference
       Region 6paw A 12-13 disorder
       Region 6paw A 14-329 order
       Region 6paw A 330-330 disorder
Seq 312-330 Hetero dimer : IID00706Complex
 Evidence X-RAY 1wrz B Reference
       Region 1wrz B 312-330 order
 Evidence X-RAY 1zuz B Reference
       Region 1zuz B 312-330 order
Seq 364-370 Hetero octamer : IID00816Complex
 Evidence X-RAY 7a6r L Reference
       Region 7a6r L 364-365 disorder
       Region 7a6r L 366-370 order
 Evidence X-RAY 7a6r G Reference
       Region 7a6r G 364-364 disorder
       Region 7a6r G 365-370 order
 Evidence X-RAY 7a6r F Reference
       Region 7a6r F 364-370 order
 Evidence X-RAY 7a6r E Reference
       Region 7a6r E 364-364 disorder
       Region 7a6r E 365-370 order
 Evidence X-RAY 7a6y M Reference
       Region 7a6y M 364-365 disorder
       Region 7a6y M 366-370 order
 Evidence X-RAY 7a6y L Reference
       Region 7a6y L 364-364 disorder
       Region 7a6y L 365-370 order
 Evidence X-RAY 7a6y K Reference
       Region 7a6y K 364-370 order
 Evidence X-RAY 7a6y J Reference
       Region 7a6y J 364-364 disorder
       Region 7a6y J 365-370 order
SeqProS predicted 364-370 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero octamer : IID00816Complex
       Region 7a6y J 365-370 order
       Region 7a6y K 364-370 order
       Region 7a6y L 365-370 order
       Region 7a6y M 366-370 order
       Region 7a6r E 365-370 order
       Region 7a6r F 364-370 order
       Region 7a6r G 365-370 order
       Region 7a6r L 366-370 order
Seqphosphorylation
    299-299 Phosphoserine
    318-318 Phosphoserine; by autocatalysis
    349-349 Phosphoserine
    369-369 Phosphothreonine; by PKB/AKT1
 
Prediction
NeProc
Disorder 1-7,58-61,295-370
Order 8-57,62-288
ProS 1-7,299-335,343-349
AlphaFold
Disorder 1-11,317-317,319-370
Order 12-316,318-318
Pfam Hmmer
PF00069 23-285 5.5e-88
Function
Function in SwissProt
Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.