Search Keyword:


Search option:


IID00891
 UniprotQ9ULW0
ProteinTargeting protein for Xklp2
GeneTPX2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
747
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-43 Hetero tetramer : IID00752Complex
 Evidence X-RAY 4c3p E Reference
       Region 4c3p E 1-3 disorder
       Region 4c3p E 4-20 order
       Region 4c3p E 21-43 disorder
 Evidence X-RAY 4c3p B Reference
       Region 4c3p B 1-5 disorder
       Region 4c3p B 6-22 order
       Region 4c3p B 23-43 disorder
Seq 1-43 Hetero dimer : IID00752Complex
 Evidence X-RAY 1ol5 B Reference
       Region 1ol5 B 1-6 disorder
       Region 1ol5 B 7-21 order
       Region 1ol5 B 22-29 disorder
       Region 1ol5 B 30-43 order
 Evidence X-RAY 3e5a B Reference
       Region 3e5a B 1-5 disorder
       Region 3e5a B 6-21 order
       Region 3e5a B 22-25 disorder
       Region 3e5a B 26-42 order
       Region 3e5a B 43-43 disorder
 Evidence X-RAY 3ha6 B Reference
       Region 3ha6 B 1-22 order
       Region 3ha6 B 23-29 disorder
       Region 3ha6 B 30-42 order
       Region 3ha6 B 43-43 disorder
 Evidence X-RAY 5lxm D Reference
       Region 5lxm D 6-22 order
       Region 5lxm D 23-27 disorder
       Region 5lxm D 28-43 order
Seq 7-21 Hetero tetramer : IID00752Complex
 Evidence X-RAY 6vpl B Reference
       Region 6vpl B 7-21 order
 Evidence X-RAY 6vpl A Reference
       Region 6vpl A 7-21 order
Seq 7-21 Hetero dimer : IID00752Complex
 Evidence X-RAY 6vph A Reference
       Region 6vph A 7-21 order
Seq 7-21 Hetero dimer : IID00752Complex
 Evidence X-RAY 6vpj A Reference
       Region 6vpj A 7-21 order
Seq 7-21 Hetero dimer : IID00752Complex
 Evidence X-RAY 6vpg A Reference
       Region 6vpg A 7-21 order
Seqdisorder 7-21
 Evidence X-RAY 6xka A Reference
       Region 6xka A 7-21 disorder
Seq 7-21 Hetero dimer : IID00752Complex
 Evidence X-RAY 6vpi A Reference
       Region 6vpi A 7-20 order
       Region 6vpi A 21-21 disorder
Seq 7-21 Hetero tetramer : IID00752Complex
 Evidence X-RAY 6vpm B Reference
       Region 6vpm B 7-21 order
 Evidence X-RAY 6vpm A Reference
       Region 6vpm A 7-21 order
Seqdisorder 30-43
 Evidence CD Reference
       Region 30-43 disorder
SeqProS verified 30-43 Hetero dimer : IID00752Complex
       Region 1ol5 B 30-43 order
       Region 3ha6 B 30-42 order
       Region 3e5a B 26-42 order
       Region 5lxm D 28-43 order
       Region 30-43 disorder
Seqphosphorylation
    499-499 Phosphothreonine
    59-59 Phosphothreonine
    72-72 Phosphothreonine
    121-121 Phosphoserine
    738-738 Phosphoserine
    125-125 Phosphoserine
    486-486 Phosphoserine
    369-369 Phosphothreonine
    359-359 Phosphoserine
    338-338 Phosphothreonine
    310-310 Phosphoserine
    293-293 Phosphoserine
    292-292 Phosphoserine
    257-257 Phosphoserine
    147-147 Phosphothreonine
Seqacetylation
    375-375 N6-acetyllysine
    305-305 N6-acetyllysine
    128-128 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-5,40-210,239-659,715-747
Order 6-39,211-238,660-714
ProS 40-44,62-68,256-265,279-285,305-316,322-343,363-382,397-413,432-438,455-469,480-495,516-557,565-577,586-611,622-645,656-659,715-747
AlphaFold
Disorder 1-35,38-209,242-256,263-263,268-280,283-283,290-323,345-367,372-381,411-422,447-455,472-473,479-479,482-482,484-484,486-486,488-539,561-568,573-573,576-578,643-659,745-747
Order 36-37,210-241,257-262,264-267,281-282,284-289,324-344,368-371,382-410,423-446,456-471,474-478,480-481,483-483,485-485,487-487,540-560,569-572,574-575,579-642,660-744
Pfam Hmmer
PF06886 662-718 3.9e-16
SEG 36-54 ,157-168 ,247-258 ,387-395 ,416-430 ,545-560 ,679-712
Function
Function in SwissProt
Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).
Biological Process
See also
Diagram with PDB data
AURKA/TPX2Crystal structure of Aurora-A bound to a hydrocarbon-stapled proteomimetic of TPX2