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IID00892
 UniprotQ9UQ84
ProteinExonuclease 1
GeneEXO1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
846
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-352 Monomer :
 Evidence X-RAY 3qe9 Y Reference
       Region 3qe9 Y 1-1 disorder
       Region 3qe9 Y 2-346 order
       Region 3qe9 Y 347-352 disorder
 Evidence X-RAY 3qe9 Z Reference
       Region 3qe9 Z 1-1 disorder
       Region 3qe9 Z 2-345 order
       Region 3qe9 Z 346-352 disorder
 Evidence X-RAY 3qea Z Reference
       Region 3qea Z 1-1 disorder
       Region 3qea Z 2-346 order
       Region 3qea Z 347-352 disorder
 Evidence X-RAY 3qeb Z Reference
       Region 3qeb Z 1-1 disorder
       Region 3qeb Z 2-346 order
       Region 3qeb Z 347-352 disorder
 Evidence X-RAY 5uzv Z Reference
       Region 5uzv Z 1-1 disorder
       Region 5uzv Z 2-345 order
       Region 5uzv Z 346-352 disorder
 Evidence X-RAY 5v04 Z Reference
       Region 5v04 Z 1-1 disorder
       Region 5v04 Z 2-346 order
       Region 5v04 Z 347-352 disorder
 Evidence X-RAY 5v05 Z Reference
       Region 5v05 Z 1-1 disorder
       Region 5v05 Z 2-346 order
       Region 5v05 Z 347-352 disorder
 Evidence X-RAY 5v06 Z Reference
       Region 5v06 Z 1-1 disorder
       Region 5v06 Z 2-346 order
       Region 5v06 Z 347-352 disorder
 Evidence X-RAY 5v07 Z Reference
       Region 5v07 Z 1-1 disorder
       Region 5v07 Z 2-345 order
       Region 5v07 Z 346-352 disorder
 Evidence X-RAY 5v08 Z Reference
       Region 5v08 Z 1-2 disorder
       Region 5v08 Z 3-345 order
       Region 5v08 Z 346-352 disorder
 Evidence X-RAY 5v09 Z Reference
       Region 5v09 Z 1-1 disorder
       Region 5v09 Z 2-345 order
       Region 5v09 Z 346-352 disorder
 Evidence X-RAY 5v0a Z Reference
       Region 5v0a Z 1-1 disorder
       Region 5v0a Z 2-345 order
       Region 5v0a Z 346-352 disorder
 Evidence X-RAY 5v0b Z Reference
       Region 5v0b Z 1-1 disorder
       Region 5v0b Z 2-345 order
       Region 5v0b Z 346-352 disorder
 Evidence X-RAY 5v0c Z Reference
       Region 5v0c Z 1-1 disorder
       Region 5v0c Z 2-345 order
       Region 5v0c Z 346-352 disorder
 Evidence X-RAY 5v0d Z Reference
       Region 5v0d Z 1-1 disorder
       Region 5v0d Z 2-346 order
       Region 5v0d Z 347-352 disorder
 Evidence X-RAY 5v0e Z Reference
       Region 5v0e Z 1-1 disorder
       Region 5v0e Z 2-346 order
       Region 5v0e Z 347-352 disorder
 Evidence X-RAY 7mxq Z Reference
       Region 7mxq Z 1-1 disorder
       Region 7mxq Z 2-346 order
       Region 7mxq Z 347-352 disorder
 Evidence X-RAY 7mxr Z Reference
       Region 7mxr Z 1-1 disorder
       Region 7mxr Z 2-346 order
       Region 7mxr Z 347-352 disorder
 Evidence X-RAY 7mxs Z Reference
       Region 7mxs Z 1-1 disorder
       Region 7mxs Z 2-346 order
       Region 7mxs Z 347-352 disorder
 Evidence X-RAY 7mxt Z Reference
       Region 7mxt Z 1-1 disorder
       Region 7mxt Z 2-346 order
       Region 7mxt Z 347-352 disorder
 Evidence X-RAY 7mxu Z Reference
       Region 7mxu Z 1-1 disorder
       Region 7mxu Z 2-346 order
       Region 7mxu Z 347-352 disorder
 Evidence X-RAY 7mxv Z Reference
       Region 7mxv Z 1-1 disorder
       Region 7mxv Z 2-346 order
       Region 7mxv Z 347-352 disorder
 Evidence X-RAY 7mxw Z Reference
       Region 7mxw Z 1-1 disorder
       Region 7mxw Z 2-346 order
       Region 7mxw Z 347-352 disorder
 Evidence X-RAY 7mxx Z Reference
       Region 7mxx Z 1-1 disorder
       Region 7mxx Z 2-345 order
       Region 7mxx Z 346-352 disorder
Seqphosphorylation
    376-376 Phosphoserine
    422-422 Phosphoserine
    454-454 Phosphoserine
    581-581 Phosphothreonine
    598-598 Phosphoserine
    610-610 Phosphoserine
    621-621 Phosphothreonine
    623-623 Phosphoserine
    639-639 Phosphoserine
    660-660 Phosphoserine
    674-674 Phosphoserine
    714-714 Phosphoserine; by ATR
    746-746 Phosphoserine
Seqacetylation
    482-482 N6-acetyllysine
 
Prediction
NeProc
Disorder 350-820
Order 1-349,821-846
ProS 350-358,367-378,393-409,418-423,484-492,499-507,605-612,670-686,724-729,736-744,751-768,777-820
AlphaFold
Disorder 1-1,347-367,378-481,483-483,494-846
Order 2-346,368-377,482-482,484-493
Pfam Hmmer
PF00752 1-99 3e-27
PF00867 138-229 8.1e-37
SEG 84-96 ,690-707
Function
Function in SwissProt
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.
Biological Process
See also
Diagram with PDB data
MSH2/MSH6/DNAhuman MutSalpha (MSH2/MSH6) bound to ADP and a G T mispair
MSH2/MSH3/DNAHuman MutSbeta complexed with an IDL of 4 bases (Loop4) and ADP