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IID00893
 UniprotQ9UQB8
ProteinBrain-specific angiogenesis inhibitor 1-associated protein 2
GeneBAIAP2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
552
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-250 Hetero tetramer : C6UYL8
 Evidence X-RAY 2ykt A Reference
       Region 2ykt A 1-3 disorder
       Region 2ykt A 4-147 order
       Region 2ykt A 148-153 disorder
       Region 2ykt A 154-234 order
       Region 2ykt A 235-250 disorder
Seq 1-250 Homo dimer :
 Evidence X-RAY 1wdz A Reference
       Region 1wdz A 1-1 disorder
       Region 1wdz A 2-228 order
 Evidence X-RAY 1wdz B Reference
       Region 1wdz B 1-1 disorder
       Region 1wdz B 2-149 order
       Region 1wdz B 150-158 disorder
       Region 1wdz B 159-228 order
 Evidence X-RAY 1y2o A Reference
       Region 1y2o A 1-248 order
       Region 1y2o A 249-250 disorder
 Evidence X-RAY 1y2o B Reference
       Region 1y2o B 1-248 order
       Region 1y2o B 249-250 disorder
Seq 260-291 Hetero dimer : IID00308Complex
 Evidence X-RAY 4js0 B Reference
       Region 4js0 B 260-262 disorder
       Region 4js0 B 263-291 order
Seq 333-346 Hetero octamer : IID00793Complex
 Evidence X-RAY 6bcr C Reference
       Region 6bcr C 333-336 disorder
       Region 6bcr C 337-345 order
       Region 6bcr C 346-346 disorder
 Evidence X-RAY 6bcr D Reference
       Region 6bcr D 333-336 disorder
       Region 6bcr D 337-345 order
       Region 6bcr D 346-346 disorder
 Evidence X-RAY 6bcr G Reference
       Region 6bcr G 333-335 disorder
       Region 6bcr G 336-345 order
       Region 6bcr G 346-346 disorder
 Evidence X-RAY 6bcr H Reference
       Region 6bcr H 333-335 disorder
       Region 6bcr H 336-345 order
       Region 6bcr H 346-346 disorder
Seq 335-366 Hetero dodecamer : IID00793Complex
 Evidence X-RAY 6bqt C Reference
       Region 6bqt C 335-336 disorder
       Region 6bqt C 337-345 order
       Region 6bqt C 346-356 disorder
       Region 6bqt C 357-365 order
       Region 6bqt C 366-366 disorder
 Evidence X-RAY 6bqt F Reference
       Region 6bqt F 335-336 disorder
       Region 6bqt F 337-345 order
       Region 6bqt F 346-356 disorder
       Region 6bqt F 357-365 order
       Region 6bqt F 366-366 disorder
 Evidence X-RAY 6bqt I Reference
       Region 6bqt I 335-336 disorder
       Region 6bqt I 337-345 order
       Region 6bqt I 346-356 disorder
       Region 6bqt I 357-364 order
       Region 6bqt I 365-366 disorder
 Evidence X-RAY 6bqt L Reference
       Region 6bqt L 335-336 disorder
       Region 6bqt L 337-345 order
       Region 6bqt L 346-356 disorder
       Region 6bqt L 357-364 order
       Region 6bqt L 365-366 disorder
Seq 335-372 Hetero trimer : IID00793Complex
 Evidence X-RAY 6bd2 C Reference
       Region 6bd2 C 335-335 disorder
       Region 6bd2 C 336-344 order
       Region 6bd2 C 345-361 disorder
       Region 6bd2 C 362-369 order
       Region 6bd2 C 370-372 disorder
Seq 354-366 Hetero octamer : Q3SZI4
 Evidence X-RAY 6bcy C Reference
       Region 6bcy C 354-355 disorder
       Region 6bcy C 356-365 order
       Region 6bcy C 366-366 disorder
 Evidence X-RAY 6bcy D Reference
       Region 6bcy D 354-355 disorder
       Region 6bcy D 356-365 order
       Region 6bcy D 366-366 disorder
 Evidence X-RAY 6bcy G Reference
       Region 6bcy G 354-355 disorder
       Region 6bcy G 356-365 order
       Region 6bcy G 366-366 disorder
 Evidence X-RAY 6bcy H Reference
       Region 6bcy H 354-356 disorder
       Region 6bcy H 357-365 order
       Region 6bcy H 366-366 disorder
Seq 360-373 Hetero octamer : Q3SZI4
 Evidence X-RAY 6bd1 C Reference
       Region 6bd1 C 360-362 disorder
       Region 6bd1 C 363-369 order
       Region 6bd1 C 370-373 disorder
 Evidence X-RAY 6bd1 D Reference
       Region 6bd1 D 360-362 disorder
       Region 6bd1 D 363-368 order
       Region 6bd1 D 369-373 disorder
 Evidence X-RAY 6bd1 G Reference
       Region 6bd1 G 360-362 disorder
       Region 6bd1 G 363-369 order
       Region 6bd1 G 370-373 disorder
 Evidence X-RAY 6bd1 H Reference
       Region 6bd1 H 360-362 disorder
       Region 6bd1 H 363-369 order
       Region 6bd1 H 370-373 disorder
Seq 375-436 Monomer :
 Evidence X-RAY 3rnj A Reference
       Region 3rnj A 375-436 order
Seq 448-464 Hetero hexamer : IID00311Complex,Q9C0D0
 Evidence X-RAY 6zeg A Reference
       Region 6zeg A 448-461 order
       Region 6zeg A 462-464 disorder
 Evidence X-RAY 6zeg B Reference
       Region 6zeg B 448-450 disorder
       Region 6zeg B 451-463 order
       Region 6zeg B 464-464 disorder
Seq 448-464 Hetero hexamer : IID00311Complex,Q9C0D0
 Evidence X-RAY 6zei A Reference
       Region 6zei A 448-450 disorder
       Region 6zei A 451-462 order
       Region 6zei A 463-464 disorder
 Evidence X-RAY 6zei B Reference
       Region 6zei B 448-451 disorder
       Region 6zei B 452-463 order
       Region 6zei B 464-464 disorder
SeqProS predicted 263-291 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00308Complex
       Region 4js0 B 263-291 order
SeqProS predicted 336-345 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero octamer : IID00793Complex
       Region 6bcr C 337-345 order
       Region 6bcr D 337-345 order
       Region 6bcr G 336-345 order
       Region 6bcr H 336-345 order
SeqProS predicted 336-345,356-369 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dodecamer : IID00793Complex
       Region 6bqt C 337-345 order
       Region 6bqt F 337-345 order
       Region 6bqt I 337-345 order
       Region 6bqt L 337-345 order
       Region 6bqt C 357-365 order
       Region 6bqt F 357-365 order
       Region 6bqt I 357-364 order
       Region 6bqt L 357-364 order
SeqProS predicted 336-345,356-369 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero trimer : IID00793Complex
       Region 6bd2 C 336-344 order
       Region 6bd2 C 362-369 order
SeqProS predicted 356-369 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero octamer : Q3SZI4
       Region 6bcy C 356-365 order
       Region 6bcy D 356-365 order
       Region 6bcy G 356-365 order
       Region 6bcy H 357-365 order
SeqProS predicted 356-369 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero octamer : Q3SZI4
       Region 6bd1 C 363-369 order
       Region 6bd1 D 363-368 order
       Region 6bd1 G 363-369 order
       Region 6bd1 H 363-369 order
SeqProS predicted 448-463 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero hexamer : IID00311Complex,Q9C0D0
       Region 6zei A 451-462 order
       Region 6zei B 452-463 order
SeqProS predicted 448-463 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero hexamer : IID00311Complex,Q9C0D0
       Region 6zeg A 448-461 order
       Region 6zeg B 451-463 order
Seqphosphorylation
    454-454 Phosphoserine
    261-261 Phosphoserine
    296-296 Phosphothreonine
    323-323 Phosphoserine
    325-325 Phosphoserine
    336-336 Phosphoserine
    340-340 Phosphothreonine
    346-346 Phosphoserine
    360-360 Phosphothreonine
    366-366 Phosphoserine
    384-384 Phosphoserine
    395-395 Phosphoserine
 
Prediction
NeProc
Disorder 1-7,148-171,196-201,230-552
Order 8-65,70-147,172-195,202-229
ProS 148-171,196-201,230-256,272-275,290-294,308-313,336-340,351-356,365-433,454-462,468-473,510-552
AlphaFold
Disorder 1-1,250-375,436-552
Order 2-249,376-435
Pfam Hmmer
PF08397 17-237 4.5e-135
PF07653 378-435 9.9e-10
SEG 320-334
Function
Function in SwissProt
Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.