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IID00896
 UniprotQ9Y3M2
ProteinProtein chibby homolog 1
GeneCBY1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
126
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-63
 Evidence NMR¸ ESI-MS¸ CD¸ DLS Reference
       Region 1-63 disorder
Seq 12-29 Hetero tetramer : IID00061Complex
 Evidence X-RAY 4wrq D Reference
       Region 4wrq D 12-17 disorder
       Region 4wrq D 18-25 order
       Region 4wrq D 26-29 disorder
 Evidence X-RAY 4wrq C Reference
       Region 4wrq C 12-17 disorder
       Region 4wrq C 18-24 order
       Region 4wrq C 25-29 disorder
SeqProS verified 18-25 Hetero tetramer : IID00061Complex
       Region 4wrq C 18-24 order
       Region 4wrq D 18-25 order
       Region 1-63 disorder
Seqphosphorylation
    9-9 Phosphoserine
    20-20 Phosphoserine
 
Prediction
NeProc
Disorder 1-30,66-66,116-126
Order 31-61,67-115
ProS 1-9,22-30,116-122
AlphaFold
Disorder 1-6,63-69,126-126
Order 7-62,70-125
SEG 71-93
Function
Function in SwissProt
Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.