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IID00898
 UniprotQ9Y6A5
ProteinTransforming acidic coiled-coil-containing protein 3
GeneTACC3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
838
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 518-563 Hetero dimer : IID00752Complex
 Evidence X-RAY 5odt B Reference
       Region 5odt B 518-521 disorder
       Region 5odt B 522-563 order
Seq 550-567 Hetero dimer : Q68FD5
 Evidence X-RAY 5ods E Reference
       Region 5ods E 550-567 order
 Evidence X-RAY 5ods F Reference
       Region 5ods F 550-567 order
 Evidence X-RAY 5ods G Reference
       Region 5ods G 550-567 order
 Evidence X-RAY 5ods H Reference
       Region 5ods H 550-567 order
Seq 758-838 Homo octamer :
 Evidence X-RAY 5lxn A Reference
       Region 5lxn A 758-838 order
 Evidence X-RAY 5lxn B Reference
       Region 5lxn B 758-758 disorder
       Region 5lxn B 759-838 order
 Evidence X-RAY 5lxn C Reference
       Region 5lxn C 758-838 order
 Evidence X-RAY 5lxn D Reference
       Region 5lxn D 758-758 disorder
       Region 5lxn D 759-838 order
 Evidence X-RAY 5lxn E Reference
       Region 5lxn E 758-838 order
 Evidence X-RAY 5lxn F Reference
       Region 5lxn F 758-759 disorder
       Region 5lxn F 760-835 order
       Region 5lxn F 836-838 disorder
 Evidence X-RAY 5lxn G Reference
       Region 5lxn G 758-837 order
       Region 5lxn G 838-838 disorder
 Evidence X-RAY 5lxn H Reference
       Region 5lxn H 758-758 disorder
       Region 5lxn H 759-838 order
Seq 758-838 Homo dimer :
 Evidence X-RAY 5lxo A Reference
       Region 5lxo A 758-837 order
       Region 5lxo A 838-838 disorder
 Evidence X-RAY 5lxo B Reference
       Region 5lxo B 758-758 disorder
       Region 5lxo B 759-838 order
 Evidence X-RAY 5lxo C Reference
       Region 5lxo C 758-838 order
 Evidence X-RAY 5lxo D Reference
       Region 5lxo D 758-759 disorder
       Region 5lxo D 760-836 order
       Region 5lxo D 837-838 disorder
 Evidence X-RAY 5lxo E Reference
       Region 5lxo E 758-838 order
 Evidence X-RAY 5lxo F Reference
       Region 5lxo F 758-759 disorder
       Region 5lxo F 760-836 order
       Region 5lxo F 837-838 disorder
 Evidence X-RAY 5lxo G Reference
       Region 5lxo G 758-837 order
       Region 5lxo G 838-838 disorder
 Evidence X-RAY 5lxo H Reference
       Region 5lxo H 758-760 disorder
       Region 5lxo H 761-838 order
SeqProS predicted 522-563 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00752Complex
       Region 5odt B 522-563 order
SeqProS predicted 550-567 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : Q68FD5
       Region 5ods E 550-567 order
       Region 5ods F 550-567 order
       Region 5ods G 550-567 order
       Region 5ods H 550-567 order
Seqphosphorylation
    177-177 Phosphoserine
    558-558 Phosphoserine; by AURKA
    434-434 Phosphoserine
    402-402 Phosphoserine
    317-317 Phosphoserine
    250-250 Phosphoserine
    175-175 Phosphoserine
    71-71 Phosphoserine
    39-39 Phosphoserine
    25-25 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-640,835-838
Order 641-834
ProS 1-73,83-94,101-107,140-156,337-346,397-420,468-478,522-543,560-582,600-607,630-640,835-838
AlphaFold
Disorder 1-54,73-336,340-404,416-525,528-528,531-557,559-563,567-639,838-838
Order 55-72,337-339,405-415,526-527,529-530,558-558,564-566,640-837
Pfam Hmmer
PF05010 637-837 2.5e-131
SEG 132-150 ,155-164 ,612-627 ,789-798
Function
Function in SwissProt
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476).
Biological Process
Diagram with PDB data
TACC3/AURKAAurora-A in complex with TACC3