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IID00899
 UniprotP19634
ProteinSodium/hydrogen exchanger 1
GeneSLC9A1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
815
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 155-180 Monomer :
 Evidence NMR 1y4e A Reference
       Region 1y4e A 155-180 order
       Region 1y4e A 155-166 high_rmsd
       Region 1y4e A 180-180 high_rmsd
Seq 226-250 Monomer :
 Evidence NMR 2l0e A Reference
       Region 2l0e A 226-250 order
       Region 2l0e A 226-233 high_rmsd
Seq 226-274 Monomer :
 Evidence NMR 2mdf A Reference
       Region 2mdf A 226-274 order
       Region 2mdf A 226-251 high_rmsd
Seq 250-274 Monomer :
 Evidence NMR 2htg A Reference
       Region 2htg A 250-274 order
       Region 2htg A 250-260 high_rmsd
       Region 2htg A 272-274 high_rmsd
Seq 431-443 Monomer :
 Evidence NMR 6bjf A Reference
       Region 6bjf A 431-443 order
Seq 447-472 Monomer :
 Evidence NMR 2kbv A Reference
       Region 2kbv A 447-472 order
Seq 503-545 Hetero dimer : Q99653
 Evidence NMR 2e30 B Reference
       Region 2e30 B 503-545 order
       Region 2e30 B 503-515 high_rmsd
       Region 2e30 B 541-545 high_rmsd
Seq 503-545 Hetero dimer : O43745
 Evidence X-RAY 2bec B Reference
       Region 2bec B 503-515 disorder
       Region 2bec B 516-540 order
       Region 2bec B 541-545 disorder
Seq 622-657 Hetero trimer : IID00706Complex
 Evidence NMR 6zbi B Reference
       Region 6zbi B 622-657 order
 Evidence NMR 6zbi C Reference
       Region 6zbi C 622-657 order
Seq 622-689 Hetero dimer : P0DP29
 Evidence X-RAY 2ygg A Reference
       Region 2ygg A 622-685 order
       Region 2ygg A 686-689 disorder
Seq 679-723 Hetero trimer : IID00060Complex,IID00069Complex
 Evidence X-RAY 6nuc C Reference
       Region 6nuc C 679-680 disorder
       Region 6nuc C 681-688 order
       Region 6nuc C 689-712 disorder
       Region 6nuc C 713-723 order
 Evidence X-RAY 6nuf C Reference
       Region 6nuf C 679-680 disorder
       Region 6nuf C 681-688 order
       Region 6nuf C 689-712 disorder
       Region 6nuf C 713-723 order
 Evidence X-RAY 6nuu C Reference
       Region 6nuu C 679-681 disorder
       Region 6nuu C 682-688 order
       Region 6nuu C 689-712 disorder
       Region 6nuu C 713-723 order
Seqdisorder 680-815
 Evidence NMR Reference
       Region 680-815 disorder
SeqProS verified 681-688,713-723 Hetero trimer : IID00060Complex,IID00069Complex
       Region 6nuu C 682-688 order
       Region 6nuf C 681-688 order
       Region 6nuc C 681-688 order
       Region 6nuu C 713-723 order
       Region 6nuf C 713-723 order
       Region 6nuc C 713-723 order
       Region 680-815 disorder
Seqphosphorylation
    729-729 Phosphoserine
    779-779 Phosphothreonine
    785-785 Phosphoserine
    787-787 Phosphoserine
    796-796 Phosphoserine
    697-697 Phosphoserine
    703-703 Phosphoserine
    723-723 Phosphoserine
    726-726 Phosphoserine
    599-599 Phosphoserine
    602-602 Phosphoserine
    603-603 Phosphothreonine
    605-605 Phosphoserine
    648-648 Phosphoserine
    693-693 Phosphoserine
 
Prediction
NeProc
Disorder 1-14,38-86,595-624,653-815
Order 15-37,87-566,571-594,625-652
ProS 1-14,38-38,604-611,617-624,653-688,699-721,729-737,759-766,791-815
AlphaFold
Disorder 1-89,91-92,123-123,126-126,441-441,507-518,521-521,541-545,548-548,564-580,582-583,591-632,634-661,681-815
Order 90-90,93-122,124-125,127-440,442-506,519-520,522-540,546-547,549-563,581-581,584-590,633-633,662-680
Pfam Hmmer
PF00999 105-505 8.3e-118
SEG 19-32 ,134-150 ,161-171 ,292-314 ,753-759 ,798-812
Function
Function in SwissProt
Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:7110335, PubMed:7603840, PubMed:11532004, PubMed:11350981, PubMed:15035633, PubMed:14680478, PubMed:17073455, PubMed:22020933, PubMed:27650500, PubMed:15677483, PubMed:32130622, PubMed:17493937). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:8901634, PubMed:12947095, PubMed:15096511, PubMed:22020933). In addition, can transport lithium Li(+) and functions also as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511).